159 research outputs found
A closed interatrial septal aneurysm mimicking a tumor in the left atrium
No full textBilir, Cemil/0000-0002-1372-4791WOS: 000240700500033PubMed: 17041713
Images in Emergency Medicine: Acute severe coronary spasm associated with 5-fluorouracil chemotherapy
No full textBilir, Cemil/0000-0002-1372-4791;WOS: 000234147700027PubMed: 16373818
Kimura Disease's: A Case Report
No full textBilir, Cemil/0000-0002-1372-4791WOS: 000272760300009Kimura is a chronic inflammatory disease at oral mucosa which presents as large subcutaneous nodules or masses on the head or neck of adulthood males The lesions characteristics are eosinophilia in lymphocytic infiltration, fibrosis and diffuse vascularity. Eosinophilia and elevated blood IgE can be present. A 62 years old female with inguinal mass and itching was presented (Turkderm 2009, 43 171-3
Prognostic Value of Volumetric Parameters of PET-CT With Stage IIIB-IV Non-Small Cell Lung Cancer
No full textAnnual Congress of the European-Association-of-Nuclear-Medicine -- OCT 15-19, 2016 -- Barcelona, SPAIN...European Assoc Nucl Me
Oral ulcers caused by Alendronate use
No full textBilir, Cemil/0000-0002-1372-4791WOS: 000258755900009Bisphosphonates are the drugs which modulate bone turnover and reduce bone reabsorbsion. Hence, they are used in postmenopausal osteoporosis, multiple myeloma or osteolisis associated with malign cancer. The rare complications are appearing more often now because of their wide use in treatments. Most important possible adverse effects belong to gastrointestinal systems; esophagitis, gastric ulcers, dyspepsia, heartburn and rarely oral ulcers, osteonecrosis on jaws and esophagial stricturs are illustrated
Prognostic Value of Pre- and Posttreatment PET/CT Parameters in Patients Diagnosed with Advanced Stage NSCLC
No full textConclusion: This study showed that the posttreatment WB TLG is significantly associated with oncologic outcomes. The metabolic changes in the mediastinal lymph nodes, as shown by the SUVmax and TLG, have a prognostic value in patients who develop new metastases during treatment. Further study in a homogenous NSCLC population can help increase our understanding of the prognostic value of PET/CT parameters
Carotid intima media thickness in 10-yr Framingham risk score 10% clinical hypothyroid and clinical hyperthyroid patients compared to risk factor matched healthy controls
No full textBilir, Cemil/0000-0002-1372-4791WOS: 000208702606057
Isolated Renal Vein Thrombosis Associated With MTHFR-1298 and PAI-1 4G Gene Mutations
No full textBilir, Cemil/0000-0002-1372-4791WOS: 000284901300019PubMed: 19825918Isolated renal vein thrombosis is very rare without the presence of nephrotic syndrome. It is more common in the newborns and infants. Whereas major risk factors in adults are the procoagulant states such as protein C or S deficiency, factor V Leiden mutation, primary or secondary antiphospholipid syndrome, severe hypothyroidism, and trauma. Here, we report a case of isolated renal vein thrombosis associated with MTHFR-1298 and PAI-1 4G gene mutations. It should be noted that the presence of MTHFR-1298 and PAI-1 4G gene mutations together might be one of the examples of genetic mutation combinations that increase the likelihood of a thrombotic event
Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells
No full textPurpose: Toll-like receptor 4 (TLR4) is over-expressed in breast tumors and thus contributing to the tumor progression and metastasis. Natural products have drawn attention in cancer immunotherapy due to their various biological activities. Curcumin is well investigated in different types of cancer. However, the mechanisms underlying its anti-inflammatory actions have not been extensively elucidated. For this purpose, we explored the inhibitory effects of curcumin on lipopolysaccharide (LPS)-induced TLR4 dependent TRIF signaling pathway in two subtypes of breast cancer cell lines (MCF-7 and MDA-MB-231) in this study. Methods: In this context, the cytotoxicity of curcumin and LPS alone and the combination of curcumin with LPS on these cells was evaluated by WST-1 assay. The expression level of TLR4 and the release of type I interferon (IFN) levels were determined after treatment with curcumin and/or LPS by RT-PCR and ELISA analysis, respectively. Furthermore, the subcellular localization of TLR4 and interferon regulatory factor 3 (IRF3) were detected by immunofluorescence analysis. Results: Curcumin treatment suppressed breast cancer cells viabilities and the activation of TLR4-mediated TRIF signaling pathway by the downregulation of TLR4 and IRF3 expression levels and the inhibition of type I IFN (IFN-alpha/beta) levels induced by LPS. However, curcumin was more efficient in MDA-MB-231 cells than MCF-7 cells owing to its greater inhibitory efficacy in the LPS-enhanced TLR4 signaling pathway. Furthermore, IFN-alpha/beta levels induced by TLR4 and IRF3 were decreased in these cells following curcumin treatment. Conclusions: Consequently, these results demonstrated that the activation of LPS stimulated TLR4/TRIF/IRF3 signaling pathway was mediated by curcumin in breast cancer cells, in vitro. However, more studies are necessary to examine the curcumin's anti-inflammatory activities on TLR4/MyD88/NF-kappa B as well as other signaling pathways downstream of TLRs in breast cancer
Relationship between 18F-FDG uptake on PET/CT and expression of Ki-67 and p53 proteins in patient with lung cancer: a clinocopathologic study
No full textBilir, Cemil/0000-0002-1372-4791Introduction
Lung cancer is the 2nd most common malignancy in both of
men and women. It is also the most common cause of cancer
related deaths.1
Nearly 85% of lung cancers were diagnosed
as large cell carcinoma, adenocarcinoma (AC), and squamous
cell carcinoma (SCC) classified as non-small cell lung carcinoma (NSCLC). One third of the newly diagnosed NSLC patients
were diagnosed at advanced stages (Stage IIIA or IIIB), and
they are not suitable for surgical treatment. The 5-year survival rate of these patients is 16%.2,
- …
