39 research outputs found
Letter from Bishop E. Mulhern to Hagan
No full textHolograph letter from Bishop E. Mulhern, Ardmaine, Newry (County Down), to (Hagan), following up on his telegram, explaining that he could not have done anything in a matter concerning an author of a book [on Ulster]. Recounting the experience of an explosion heard the previous night the cause of which is still unclear. Commenting that 'Raphoe is dragging a "lengthening chain"' after a prolonged investigation; that Dr. O'D[onnell] can now appoint parish priests but might not care to exercise the privilege since the main parishes are endowed
Knowledge and innovation in the interface between the steel and automotive industries: The case of Dofasco
No full textWarrian, P. and Mulhern, C. (2005) Knowledge and innovation in the interface between the steel and automotive industries: the case of Dofasco, Regional Studies 39 , 161–170. The key motivation behind innovation in the steel industry has been the revolution in vehicle manufacturing, as automotive steel represents the largest source of revenue for integrated mills. The paper examines in a comparative context the innovative practices of North America's most profitable integrated automotive steel producer, Dofasco Inc. It seeks to elucidate conclusions from previous work on knowledge derived from participation in global learning networks. The authors claim that Dofasco is a commercialization‐stage innovator. It adds value to a product or process as it meets the market, but does not significantly contribute to fundamental and applied scientific research in automotive steel production. The geographic sphere in which most of Dofasco's customer‐oriented innovation occurs is in a regional system of innovation, specifically the automotive parts and assembly hub of south‐western Ontario and Michigan.Steel, Automotive, Innovation, Knowledge, Networks, Acier, Automobile, Innovation, Connaissance, Réseaux, Stahl, Auto, Innovation, Fachkenntnisse, Netzwerke, Acero, Industria automotora, Innovación, Conocimiento, Redes, JEL classifications: L62, M21, R00,
Globalization and the selective permeability of public policy-making: The case of K--12 education in Ontario, 1990--2003
No full textThis dissertation applies Hall's (1993) model of a policy paradigm to the case of education reform in Ontario for the purposes of exploring the validity of the "globalization thesis," the claim that the dominance of business interests in domestic politics has made the welfare state unsustainable. From 1990 to 2003, successive governments led by the social democratic New Democratic Party and the "New Right" (neoliberal and neoconservative) Progressive Conservative Party launched the most comprehensive reorganization of primary and secondary ("K-12") education since the 1960s. By the end of this period, it was commonly held that the welfare state model of the post-war era (1945-1990) had been replaced by the New Right model of "Outcomes-Based Education" (OBE). The rise of OBE was seen as proof of the demise of both: (1) partisan agency (the ability of governments to make policy not contradictory to their core beliefs about the role of government); and (2) electoral politics (the public's capacity to block unpopular reforms via the ballot).A review of the evidence disproves these two popular conclusions. First, Hall's conditions for policy change---a simultaneous shift in the three "orders" of policy ("goals," "programs," and "detailed settings")---were not met; rather, change occurred only at the programmatic and settings levels. While major policy adjustments were made during the thirteen year period, the welfare state goals of decommodification, destratification, and social solidarity were not appreciably diminished. Second, the left-of-centre preferences of the New Democrats were no more constrained than usual in the liberal market context of Ontario; and, contrary to globalizationist predictions, the Tories did not have "carte blanche" to remake education in the image of the New Right. Ultimately, in complex areas of social policy, proof of paradigmatic change and/or democratic nullification does not lie in surface-level evidence of programmatic adjustments. Instead, it is necessary to inquire into: (1) the ideas about government apparent in policy statements, the policy-making process, and final decisions; and, (2) the intentions of decision-makers themselves.Ph.D
Feminist analyzes women poets
No full textThe study of the works of 18th century women poets can help lead to an understanding of the type of lives they led, feminist author Germaine Greer told 250 persons in 101 English/Math Friday night
Ritual Abuse: Defining a Syndrome versus Defending a Belief
No full text The author briefly reviews her research showing how SRA training seminars proposed to mental health professionals between 1987 and 1990 constituted a form of proselytizing. Such presentations were designed to convert clinicians before they began listening to patients to believe in the plausible existence of satanic blood cults. Diagnostic and treatment techniques recommended in SRA seminars, as well as postulated explanations for patients’ exacerbated clinical symptoms, all pre-supposed the facticity of networks of organized groups of perpetrators. Since the author first presented the results of this study to mental health professionals between 1989–91, some SRA “experts” have slightly modified their presentations in order to acknowledge the limits of hypnotic memory retrieval techniques and the risks of confabulation and uncontrolled counter-transference with highly suggestible patients suffering from memory disorders. Many others, however, continue to employ proselytizing techniques which are inappropriate in medical education courses. Patients’ better interests are ill served when their therapists’ “educated” ears have been deafened by uncritical belief. </jats:p
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Evaluation of a Social Media Bot Detector for integration into MITRE SP!CE™
No full textSocial media bots have become an inevitable nuisance for online communities. These bots are used to heavily influence these communities by either drowning out actual conversation or control the narrative. Due to their potential, social media companies and governments are intensely interested in identifying and minimizing the impact of bot actors. Bot detectors can detect some bot activity, but different methods vary in their ability to correctly classify users. This study aims to evaluate a method of bot detection called the Rest-Sleep-Comment (RSC) method for integration into MITRE SP!CE™. This detector should be able to be to detect bots at the same rate as proposed in the original RSC paper. The data that was used for evaluating the detector is Reddit data from September 2015, October 2015, June 2020, and June 2021. This data was stripped down to only the data needed, which were the author and created_utc keys. Originally, there were no bot accounts in the dataset. Without any bots, the detector could not be properly trained. It was then decided to fabricate bot accounts using noised timestamps. These synthetic bot accounts were then added to the datasets. These new datasets were then used to test the detector again. Once the detector was made and the dataset contained bot accounts, the detector was run and the results were not promising. The detector was unable to classify any bot accounts correctly. Therefore, the detector should not be integrated into MITRE SP!CE™
ΤΩΝ ΛΟΓΩΝ Ο ΠΡΩΤΟΣ ΤΕ ΚΑΙ ΣΜΙΚΡΟΤΑΤΟΣ, Sph. 262c6-7: The First and LIttlest of Sentences
No full textIn this paper I show that the orthodox syntax suggested in Sophistes 262C6-7 and the surrounding text is not adhered to in the dialogues. Within the limited universe of monadic atomic sentence syntax extended with constants for existence and unity, in fact, all but three of the 14 possible irregular forms are used in one or other of the three dialogues instanced here. Self-predication, which, in the mid-twentieth-century, fascinated so many scholars, turns out to be just one among the many varieties of irregular syntax in the dialogues.
The nonadherence of other interlocutors to the Eleatic Stranger’s description of monadic atomic sentences enables these interlocutors to talk about Ideas in the dialogues in familiar ways; unless the syntactically irregular sentences were used, the interlocutors would not have been able to talk about Ideas the way they did. The dialogues contain a variety of sentences and sentence schemata that we commonly consider ill formed and that we should expect to produce peculiar results when used in argument. Of course, there are no grounds for attributing syntactical insensitivity to Plato the author who, himself, represents this insensitivity in an orderly and carefully structured way as characterizing the conversation of some of his fictionalized interlocutors.
The appearance of these irregular sentences in the dialogues apparently engaged Aristotle, who devoted much attention to what can and what cannot be predicated of what. Thus in Aristotle one finds a theory of predication which systematically excludes the irregular sentences. The Categoriae addresses what can and cannot be said of what in the normal course of things, and the Tópica addresses, for example, unity and existence as predicates. I would suggest in closing that the apparatus I have offered here provides a largely unexplored way to reconstruct the controversies of the Academy and to track the way they led predication. into the development of what we have begun to understand as Aristotle’s theory of predication
results from the ICEBERG study
No full textFunding Information: AJO-M: received grants from Compass Pathways, Ltd., Janssen and Schuhfried GmBH; investigator driven research funded by Funda\u00E7\u00E3o para Ci\u00EAncia e Tecnologia (PTDC/SAU-NUT/3507/2021; PTDC/MED-NEU/1552/2021; PTDC/MED NEU/31331/2017), Funda\u00E7\u00E3o para Ci\u00EAncia e Tecnologia and FEDER (PTDC/MED-NEU/30845/2017_LISBOA-01-0145-FEDER-030845; PTDC/MEC-PSQ/30302/2017_LISBOA-01-0145-FEDER-30302), the European Research Council (ERC-2020-STG-Grant 950357), the European Union Horizon programmes H2020 SC1 2017 CNECT 2 777167 BOUNCE; (H2020 SC1 DTH 2019 875358 FAITH; HORIZON-HLTH-2023-DISEASE-03-101137378-PsyPal) and the European Joint Programme in Rare Diseases (Joint Translational Call 2019) through Funda\u00E7\u00E3o para Ci\u00EAncia e Tecnologia (EJPRD/0001/2020); received payment, honoraria or support for attending meetings from MSD, Neurolite AG Angelini, Janssen and the European Monitoring Centre for Drugs and Drug Addiction; Vice-President of the Portuguese Society for Psychiatry and Mental Health; Head of the Psychiatry Working Group for the National Board of Medical Examination (GPNA) at the Portuguese Medical Association and Portuguese Ministry of Health. BR, YG, and SM-H: Employees of Janssen; hold Johnson & Johnson company stocks/stock options. Funding Information: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The authors declare that this study received funding from Janssen EMEA. This article was based on the original studies NCT02497287 and 54135419DEP4001, both sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Laura Mawdsley, MSc, Costello Medical, Cambridge, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP 2022) guidelines. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. Funding Information: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The authors declare that this study received funding from Janssen EMEA. This article was based on the original studies NCT02497287 and 54135419DEP4001, both sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Laura Mawdsley, MSc, Costello Medical, Cambridge, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP 2022) guidelines. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. Acknowledgments Publisher Copyright: Copyright © 2024 Oliveira-Maia, Rive, Godinov and Mulhern-Haughey.Introduction: Treatment resistant depression (TRD) affects approximately 10–30% of patients with major depressive disorder, and most patients with TRD do not respond to real-world treatments (RWT). Treatment with esketamine nasal spray (NS) plus a selective serotonin or serotonin norepinephrine reuptake inhibitor (SSRI/SNRI) has significant long-term clinical benefit over RWT in patients with TRD. However, the impact on patient-reported function remains to be determined. Methods: The ICEBERG analysis was an indirect treatment comparison performed using data from two studies of patients with TRD: SUSTAIN-2 (esketamine NS; NCT02497287) and the European Observational TRD Cohort (EOTC; RWT; NCT03373253; clinicaltrials.gov). Here, patient−reported functional remission, assessed using the Sheehan Disability Scale (SDS), was defined as SDS ≤6 at Month 6. Analyses were conducted using propensity score re−weighting and multivariable models based on 18 covariates. Results: At Month 6, the probability of functional remission in esketamine NS−treated patients from SUSTAIN-2 (n=512) was 25.6% (95% confidence interval [CI] 21.8–29.4), while the adjusted probability for RWT patients from the EOTC (n=184) was 11.5% (95% CI 6.9–16.1; relative risk: 2.226 [95% CI 1.451–3.416]; p=0.0003). In the total combined population (N=696), patients who did not achieve clinical response or remission had a low probability of achieving functional remission (5.84% and 8.76%, respectively). However, for patients who did achieve clinical response or remission, the probability of achieving functional remission was greater (43.38% and 54.15%, respectively), although many still did not achieve this status. Conclusions: For patients with TRD, esketamine NS had a significant functional benefit versus RWT after 6 months of treatment. Irrespective of treatment, achievement of clinical response or remission was insufficient to attain functional remission. Nevertheless, clinical remission increased the likelihood of achieving functional remission, further supporting an important role for clinical remission in for the path towards functional recovery.publishersversionpublishe
Avian Cholera in a Bald Eagle from Ohio
No full textAuthor Institution: Patuxent Wildlife Research Center, Laurel, Maryland 20810, and Department of Veterinary Science (J. A. N.), University of Maryland, College Park, Maryland 20742Avian cholera (Pasteurella multocida) infection was diagnosed in an adult male bald eagle (Haliaeetus leucocephalus) collected in Ohio. Brain levels of organochlorine pesticides were found to be well below the reported lethal levels; the brain contained 10.7 ppm p,p'-DDE, 0.4 ppm p,p'-DDD, 1.2 ppm dieldrin, 1.1 ppm heptachlor epoxide, and 40.0 ppm polychlorinated biphenyls (PCB)
