1,720,998 research outputs found
Politiche per la promozione di cluster d’imprese nei Paesi in via di sviluppo. Il dibattito internazionale e l'esperienza UNIDO
No full textA partire dagli anni Settanta la letteratura internazionale che concentrata la propria attenzione sulle dinamiche di sviluppo industriale iniziava ad accogliere alcune nuove intuizioni in materia di governo e organizzazione della produzione. Tale cambio di prospettiva fu ispirato dalla crisi dei modelli consolidati e dalle esperienze delle diverse ondate di late comers che suggerivano la possibilità di percorsi di crescita e sviluppo industriale anche profondamente diversi. In questo quadro grande spazio si è ritagliato il fenomeno dei cluster. Il dibattito accademico è diventato presto un dibattito europeo e quindi internazionale. In questo quadro i paragrafi che seguono affrontano due questioni: a) i cluster sono un fenomeno che caratterizza le realtà produttive dei PVS? b) i cluster devono essere guidati e promossi dall'intervento di policy? Il saggio offre quindi un'analisi di quanto UNIDO oggi promuove nei PVS in questo campo e si conclude con alcune riflessioni che cercano di evidenziale le principali problematiche con cui confrontarsi
Genomic Characterization of Acute Leukemias.
No full textOver the past two decades, hematologic malignancies have been extensively evaluated due to the introduction of powerful technologies, such as conventional karyotyping, FISH analysis, gene and microRNA expression profiling, array comparative genomic hybridization and SNP arrays, and next-generation sequencing (including whole-exome sequencing and RNA-seq). These analyses have allowed for the refinement of the mechanisms underlying the leukemic transformation in several oncohematologic disorders and, more importantly, they have permitted the definition of novel prognostic algorithms aimed at stratifying patients at the onset of disease and, consequently, treating them in the most appropriate manner. Furthermore, the identification of specific molecular markers is opening the door to targeted and personalized medicine. The most important findings on novel acquisitions in the context of acute lymphoblastic leukemia of both B and T lineage and de novo acute myeloid leukemia are described in this review
GATA 2 Deficiency: Focus on Immune System Impairment
Full text linkGATA2 deficiency is a disease with a broad spectrum of clinical presentation, ranging from lymphedema, deafness, pulmonary dysfunction to miscarriage and urogenital anomalies, but it is mainly recognized as an immune system and bone marrow disorder. It is caused by various heterozygous mutations in the GATA2 gene, encoding for a zinc finger transcription factor with a key role for the development and maintenance of a pool of hematopoietic stem cells; notably, most of these mutations arise de novo. Patients carrying a mutated allele usually develop a loss of some cell populations, such as B-cell, dendritic cell, natural killer cell, and monocytes, and are predisposed to disseminated human papilloma virus and mycobacterial infections. Also, these patients have a predisposition to myeloid neoplasms, including myelodysplastic syndromes, myeloproliferative neoplasms, chronic myelomonocytic leukaemia. The age of symptoms onset can vary greatly even also within the same family, ranging from early childhood to late adulthood; incidence increases by age and most frequently clinical presentation is between the second and third decade of life. Currently, haematopoietic stem cell transplantation represents the only curative treatment, restoring both the hematopoietic and immune system function
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Politiche per la promozione di cluster d’imprese. Interventi nei paesi in via di sviluppo
No full textA partire dagli anni Settanta la letteratura internazionale che concentrata la propria attenzione sulle dinamiche di sviluppo industriale iniziava ad accogliere alcune nuove intuizioni in materia di governo e organizzazione della produzione. Tale cambio di prospettiva fu ispirato dalla crisi dei modelli consolidati e dalle esperienze delle diverse ondate di late comers che suggerivano la possibilità di percorsi di crescita e sviluppo industriale anche profondamente diversi. In questo quadro grande spazio si è ritagliato il fenomeno dei cluster. Il dibattito accademico è diventato presto un dibattito europeo e quindi internazionale. In questo quadro i paragrafi che seguono affrontano due questioni: a) i cluster sono un fenomeno che caratterizza le realtà produttive dei PVS? b) i cluster devono essere guidati e promossi dall'intervento di policy? Il saggio offre quindi un'analisi di quanto UNIDO oggi promuove nei PVS in questo campo e si conclude con alcune riflessioni che cercano di evidenziale le principali problematiche con cui confrontarsi
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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