1,720,964 research outputs found
ELECTROENCEPHALOGRAPHIC INSIGHTS INTO COGNITIVE DYSFUNCTION
Get PDFBackground. Amidst the complexity of the COVID-19 pandemic and the emergence of disease-modifying therapies for Alzheimer’s Disease (AD), an exploration of the neuroelectrical correlates of AD and Post-COVID-19 Syndrome (PCS) through resting-state EEG (RS-EEG) has transitioned into a critical global health inquiry. Initially, this Ph.D. research, aimed at unraveling AD complexities, was navigated towards addressing both the challenges in participant recruitment and emerging cognitive impairments associated with PCS, expanding its scope to the cognitive implications post-COVID-19. Hence, this work attempts to delineate the neurophysiological and cognitive disruptions in AD and PCS, adapting to the demands imposed by the pandemic.
Methods. A comprehensive approach, integrating EEG analyses with neuroimaging, laboratory and structured neuropsychological assessments, facilitated an exploration of AD and PCS. In AD, the research prioritizes investigating EEG as a potential early diagnostic marker, while in PCS, it emphasizes exploring the neuroelectrical correlates of cognitive and psychiatric disturbances up to 10 months post-COVID-19 resolution.
Results. In AD, findings identify alterations in the theta and alpha2 bands as potential diagnostic indicators, aiding early differential diagnosis and prognostication of dementia subtypes and cognitive trajectories. In PCS, 53% of patients exhibited substantial cognitive disturbances, with discernible EEG alterations and acute-phase symptoms, specifically dysgeusia and hyposmia, highlighting potential vulnerabilities and correlations with memory and executive function impairments over time.
Conclusion. While findings from AD and PCS are divergent in nature and manifestation, they elucidate complex neuroelectrical substrates associated with cognitive and potential psychiatric manifestations. By identifying condition-specific neuroelectrical underpinnings, this research not only augments understanding of these conditions but also provides a foundation for subsequent research and the development of therapeutic strategies, aiming to manage and potentially mitigate cognitive impairments across various neurological conditions.Introduzione. Nel contesto della pandemia da COVID-19 e dell'emergere di terapie disease-modifying per la malattia di Alzheimer (AD), l'indagine dei correlati neuroelettrici dell'AD e della Sindrome post-COVID-19 (PCS) mediante l'EEG a riposo (RS-EEG) ha acquisito maggior centralità. Inizialmente, questa ricerca di dottorato, mirata a svelare le complessità dell'AD, è stata ostacolata dalle sfide nella reclutamento dei partecipanti. Considerati gli emergenti deficit cognitivi associati alla PCS, ha espanso il suo campo di indagine alle implicazioni cognitive post-COVID-19. Pertanto, questo lavoro cerca di delineare le alterazioni neurofisiologiche e cognitive nell'AD e nella PCS, adattandosi alle esigenze imposte dalla pandemia.
Metodi. Un approccio multidimensionale, che integra analisi EEG con neuroimaging, laboratorio e valutazioni neuropsicologiche strutturate, ha agevolato l'esplorazione dell'AD e della PCS. Nell'AD, la ricerca dà priorità all'indagine dell'EEG come possibile biomarcatore diagnostico precoce, mentre nella PCS si concentra sull'esplorare i correlati neuroelettrici dei disturbi cognitivi e psichiatrici fino a 10 mesi dalla risoluzione della malattia da COVID-19.
Risultati. Nell'AD, i risultati identificano alterazioni nelle bande theta e alpha2 come potenziali indicatori diagnostici, che contribuiscono alla diagnosi precoce e alla previsione dei sottotipi di demenza e delle traiettorie cognitive. Nella PCS, il 53% dei pazienti ha mostrato disturbi cognitivi, con alterazioni EEG specifiche. Particolare sintomi della fase acuta, in particolare disgeusia e iposmia, mettono in evidenza potenziali vulnerabilità e correlazioni con disturbi della memoria e delle funzioni esecutive nel tempo.
Conclusioni. Sebbene i risultati relativi all'AD e alla PCS siano di natura e manifestazione divergente, essi chiariscono complessi substrati neuroelettrici associati alle manifestazioni cognitive e potenziali manifestazioni psichiatriche. Identificando le basi neuroelettriche specifiche per ciascuna condizione, questa ricerca non solo incrementa la comprensione di tali condizioni, ma fornisce anche una base per ulteriori ricerche e lo sviluppo di strategie terapeutiche, mirate a gestire e potenzialmente mitigare i deficit cognitivi in diverse condizioni neurologiche
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Redefinition of dementia care in Italy in the era of amyloid-lowering agents for the treatment of Alzheimer's disease: an expert opinion and practical guideline
Get PDF: No disease-modifying therapies are currently available for Alzheimer's disease (AD) in Europe. Current evidence from clinical trials testing anti-beta amyloid (Aβ) monoclonal antibodies (mAbs) in patients with early AD, though, suggests a likely marketing authorization in the next years. Since the implementation of disease-modifying therapies for AD in the clinical practice will evidently require a huge change of dementia care in all countries, a group of prominent AD clinical experts in Italy met to discuss patients' selection and management strategies. The current diagnostic-therapeutic standard of care in Italy was taken as the starting point. The prescription of new therapies cannot ignore the definition of a biological diagnosis through the assessment of both amyloid- and tau-related biomarkers. The high risk/benefit ratio of anti-Aβ immunotherapies, moreover, needs a highly specialized diagnostic work-up and a thorough exclusion criteria assessment, which should be provided by a neurology specialist. The Expert Panel also suggests a reorganization of the Centers for dementia and cognitive decline in Italy into 3 levels of increasing complexity: community center, first- and second-level center. Tasks and requirements for each level were defined. Finally, specific characteristics of a center deputed to prescribe anti-Aβ mAbs were discussed
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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