98 research outputs found
Simvastatin releasing novel PCL scaffolds in rat cranium defects
No full textConference of the Tissue-Engineering-and-Regenerative-Medicine-International-Society (TERMIS-EU) -- SEP 04-07, 2007 -- London, ENGLANDBolgen, Nimet/0000-0003-3162-0803; Meydanli, E. Elif Guzel/0000-0001-9072-3322; Cartmell, Sarah/0000-0001-6864-0846; Bolgen, Nimet/0000-0003-3162-0803; Cavusoglu, Turker/0000-0001-7100-7080…Tissue Engn & Regenerat Med Int Soc, European Chapter, UK Tissue & Cell Engn So
BMP-7 expressing genetically modified primary chondrocytes in cryogel scaffolds for rabbit auricular cartilage repair
No full textOdabas, Sedat/0000-0002-7844-7019; Cavusoglu, Turker/0000-0001-7100-7080
Corrigendum: Anemia detection through non-invasive analysis of lip mucosa images
No full textIn the published article, there was an error in the author list. The new requested author order is: Shekhar Mahmud1, Turker Berk Donmez2, Mohammed Mansour3*, Mustafa Kutlu3 and Chris Freeman41 Department of Systems Engineering, Military Technological College, Muscat, Oman 2 Department of Biomedical Engineering, Sakarya University of Applied Sciences, Serdivan, Sakarya, Türkiye 3 Department of Mechatronics Engineering, Sakarya University of Applied Sciences, Serdivan, Sakarya, Türkiye 4 Electronics and Computer Sciences, University of Southampton, Southampton, United Kingdom The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. Copyright © 2023 Mahmud, Donmez, Mansour, Kutlu and Freeman
Patterns of collaboration in four scientific disciplines of the Turkish collaboration network
No full textScientific collaboration networks, as a prototype of complex evolving networks, are studied in many aspects of their structure and evolving characteristics. The organizing principles of these networks also vary in different scientific disciplines, demonstrating that each discipline has specific connecting rules. Retrieving the co-authorship data from the ISI Web of Science, we constructed networks of four disciplines (engineering, mathematics, physics and surgery) as a subset of the Turkish scientific collaboration network spanning 33 years' data, To provide a comparative perspective on the network topologies, we studied some statistical and topological properties such as the number of authors, degree distributions, authors per paper and papers per author histograms and distributions. These properties yield that the rapid growth of high education in Turkey (i.e. doubling of the number of universities and students within the last decade) had boosted the number of publications and increased the level of collaborations in the scientific collaboration networks. We showed the occurrence of Matthew effect in career longevity distributions, and also outlined the Heaps' law relation in the scaling of the collaborations as well. We outlined the prominent properties of each subset, while the similarities and deviations from the interdisciplinary networks are also evaluated. (C) 2014 Elsevier B.V. All rights reserved
Urotensin receptor antagonist palosuran attenuates cyclosporine-a-induced nephrotoxicity in rats
No full textCavusoglu, Turker/0000-0001-7100-7080; uyanikgil, Yigit/0000-0002-4016-0522; Kozcu, Fatma Gul/0000-0003-1304-8065; uyanikgil, Yigit/0000-0002-4016-0522Background. Cyclosporine-A (CsA) is widely used for immunosuppressivetherapy in renal transplantation. Nephrotoxicity is the main dose-limiting undesirable consequence of CsA. Urotensin II (U-II), a novel peptide with a powerful influence on vascular biology, has been added to the list of potential renal vascular regulators. Upregulation of the urotensin receptors and elevation of plasma U-II levels are thought to possibly play a role in the etiology of renal failure. Objectives. the present study examines this hypothesis by evaluating renal function and histology with regard to the potential role of U-II and its antagonist, palosuran, in the pathogenesis of CsA-induced nephrotoxicity in rats. Material and methods. Male Sprague-Dawley rats were treated with CsA (15 mg/kg, for 21 days, intraperitoneally) or CsA + palosuran (300 mg/kg, for 21 days). Renal function was measured and histopathology, U-II immunostaining and protein detection with western blotting of the kidneys were performed. Results. Cyclosporine-A administration caused a marked decline in creatinine clearance (Ccr). Fractional sodium excretion (FENa) tended to increase in the CsA-treated rats. Plasma U-II levels decreased in the CsA-treated rats. Cyclosporine-A treatment resulted in a marked deterioration in renal histology and an increase in the expression of U-II protein in the kidneys. Palosuran's improvement of renal function manifested as a significant decrease in serum creatinine levels and a significant increase in urine creatinine levels, resulting in a marked increase in Ccr. Palosuran produced a significant normalization of kidney histology and prevented an increase in U-II expression. Conclusions. Cyclosporine-A-induced renal impairment was accompanied by an increase in U-II expression in kidneys and a contrary decrease in systemic U-II levels. Palosuran improved the condition of rats suffering from renal dysfunction by preventing the decrease in renal U-II expression without affecting the systemic levels of U-II. the protective effect of palosuran in CsA nephrotoxicity is possibly independent of its U-II receptor antagonism
Detailing the co-authorship networks in degree coupling, edge weight and academic age perspective
No full textScientific collaboration networks are good resources for understanding self-organizing systems, reflecting the main generic properties like clustering, small-world and scale-free degree distribution. Beyond discovering the evolution of main parameters, we aimed to uncover the microscopic wiring properties in this study. We focused on the degree circumstances of pairing nodes together with degree differences, academic age differences and link weights. Analyzes are visualized by single distribution plots of the network parameters together with the 2D coupling characteristics of these parameters with a logarithmic colorbar as a third dimension, drawing visual perspective presenting who prefers connecting to whom during the network evolution. We showed that majority of the edges in the co-authorship network connects the nodes of comparable degrees and academic ages, featuring that strong collaboration activities occur between comparable academic careers. We also stated out that beyond the node degree distributions, power-law regimes are also observed in link weight and degree difference distributions. (C) 2016 Elsevier Ltd. All rights reserved
Effect of taurine on rat achilles tendon healing
No full textCavusoglu, Turker/0000-0001-7100-7080; uyanikgil, Yigit/0000-0002-4016-0522; uyanikgil, Yigit/0000-0002-4016-0522; akdemir, ovunc/0000-0003-1167-5890; BINBOGA, ERDAL/0000-0003-1666-7304Taurine has anti-inflammatory and antioxidant characteristics. We have introduced taurine into a tendon-healing model to evaluate its effects on tendon healing and adhesion formation. Two groups of 16 rats underwent diversion and repair of the Achilles tendon. One group received a taurine injection (200 mg/ml) at the repair site, while the other group received 1 ml of saline. Specimens were harvested at 6 weeks and underwent biomechanical and histological evaluation. No tendon ruptured. Average maximum load was significantly greater in the taurine-applied group compared with the control group (p 0.05). After histological assessment, we found that fibroblast proliferation, edema, and inflammation statistically decreased in the treatment group (p < 0.05). These findings could indicate greater tendon strength with less adhesion formation, and taurine may have an effect on adhesion formation
Traction vasculogenesis: Experimental vessel elongation by traction in rat model
No full textBackground: Microsurgeons may face inadequate vessel length in traumatic or post-resection vascular defects and flap surgery. As tissue regeneration by mechanical forces is possible like in tissue expansion and distraction osteogenesis, we questioned the effect of traction forces on isolated vessels, generated by an internal maxillary distraction device to overcome such problem. Methods: 30 Wistar-Albino rats were randomized in two groups as control and traction. By an internal maxillary distraction device placed subcutaneously to abdominal region, femoral artery and vein of traction group were applied daily traction for 10 days perpendicular to their course. Control group received the same procedure but no traction was applied. Vessel length, blood flow and histologic and microangiographic changes were evaluated on postoperative 11th day. Results: Final length of vessels was found to be higher in the traction group (21.93 mm) compared to control group (12.86 mm). (P = 0.000) Blood-flow patency rate of artery and vein was found 100 % in control group (n = 15) and 80 % in experiment group (n = 12). Microangiographic study showed patent blood flow in both control and traction groups. Histologic evaluation showed vascular wall thickening, perivascular adipocyte and neutrophil infiltration and vein lumen enlargement compared to control group. Conclusion: The preliminary “traction vasculogenesis” technique is found to be a promising technique to gain vessel length in vascular shortness problems. With further studies and refinements this technique may be carried to clinical applications in cases of vascular inadequacy
Ottoman-Turkish heritage narratives in museum practice: from Empire to Republic
No full textIn the decades surrounding the turn of the 20th century the world witnessed the collapse of once great empires and the rise of independent nation-states. With this reconception of the political world order there was an impact in the development of heritage discourses. Museums, archaeology, and collecting were mobilized for the purpose of creating a cohesive state identity. One region that experienced this tremendous social and political change was Asia Minor - that part of the Ottoman Empire that would become the Turkish Republic. How is this radical shift in political ideology reflected in the choices of museum practitioners of the time, and how do these represent a shift in desired representation of Turkish identity? This thesis explores this central question through a comparative analysis of collections at the Istanbul Archaeology Museums and the Anatolian Civilizations Museum, in Ankara. By examining each museums’ early history and the way they have chosen, grouped, and arranged artifacts for display, this thesis looks at the underlying motivations which contributed to particular heritage narratives in each period.M.A.Includes bibliographical reference
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