295 research outputs found
No relationship between red blood cell distribution width and microcirculatory alterations in septic patients
No full textBackground: Increased red cell distribution width (RDW), a quantitative measure of erythrocyte size variability, has been associated with increased mortality in critically ill patients.
Methods: In this post-hoc analysis of prospectively collected data, we studied 122 septic patients with and without shock who had undergone sublingual microcirculatory assessment using Sidestream Dark Field (SDF) videomicroscopy. Patient demographics, comorbidities, the Acute Physiology and Chronic Health Evaluation (APACHE) II score on admission and the Sequential Organ Failure Assessment (SOFA) score on the day of the microcirculatory assessment were collected. The RDW was retrospectively collected on the day of the microcirculatory evaluation from the routine daily blood count analysis.
Results: Median patient age was 68[55-77] years, and median APACHE II and SOFA scores were 22[17-28] and 10[8-12], respectively; ICU mortality was 43%. On the day of the microcirculatory analysis, the median RDW was 13.8[12.8-15.5]% and was elevated (>13.4%) in 74 (61%) patients. There was no correlation between RDW and microcirculatory parameters (functional capillary density, r2 = 0.12; proportion of small perfused vessels, r2 = 0.17; mean flow index, r2 = 0.14). RDW was not related to disease severity, the presence of shock or survival.
Conclusions: RDW is not associated with microcirculatory alterations or prognosis in septic patients.BACKGROUND: Increased red cell distribution width (RDW), a quantitative measure of erythrocyte size variability, has been associated with increased mortality in critically ill patients. METHODS: In this post-hoc analysis of prospectively collected data, we studied 122 septic patients with and without shock who had undergone sublingual microcirculatory assessment using Sidestream Dark Field (SDF) videomicroscopy. Patient demographics, comorbidities, the Acute Physiology and Chronic Health Evaluation (APACHE) II score on admission and the Sequential Organ Failure Assessment (SOFA) score on the day of the microcirculatory assessment were collected. The RDW was retrospectively collected on the day of the microcirculatory evaluation from the routine daily blood count analysis. RESULTS: Median patient age was 68[55-77] years, and median APACHE II and SOFA scores were 22[17-28] and 10[8-12], respectively; ICU mortality was 43. On the day of the microcirculatory analysis, the median RDW was 13.8[12.8-15.5] and was elevated (>13.4) in 74 (61) patients. There was no correlation between RDW and microcirculatory parameters (functional capillary density, r2 = 0.12; proportion of small perfused vessels, r2 = 0.17; mean flow index, r2 = 0.14). RDW was not related to disease severity, the presence of shock or survival. CONCLUSIONS: RDW is not associated with microcirculatory alterations or prognosis in septic patients
The Comparative Analysis of the Legal Bases Regulating the Principles of the Organization of Local Government in the Russian Federation, Provided By the Federal Law of 28.08.1995 N 154-FZ and the Federal Law of 06.10.2003 N 131-FZ
No full textThe article is devoted to research of the legal bases regulating the principles of the organization of local government in the Russian Federation, provided by the Federal law of 28.08.1995 N 154-FZ and the Federal law of 06.10.2003 N 131-FZ. The author analyzes the key differences in the organization of local government in the considered federal laws. The emphasis is placed on the following areas: the content of the conceptual apparatus of the organization of local government, a list of issues of local importance, regulation of vesting of local government with separate state powers, the structure of local government bodies, the competence of the representative body of local government, as well as forms of implementation of local government by the population. The Federal law of 06.10.2003 № 131-FZ introduced changes in almost all aspects of the functioning of local government
Financing transactions in Russia
No full textPhDThe thesis analyzes Russian laws of security and insolvency and reviews common legal issues
arising in cross-border financing transactions. To aid better understanding of up-to-date
Russian law, the analysis includes historical information.
The thesis concludes that Russian law traditionally did not adopt a regime favorable to
lenders and that the law of security was inefficient. In addition, commercial practice suffered
from the inflexible approach of courts to innovations. Statutory law was not appropriate for
commercial, as opposed to retail, transactions. This situation may be partially attributed to
the recent transition from planned to market economy and, hence, relatively short history of
modern Russian law.
The thesis highlights recent Russian legal reforms and their impact on lending practices. At
the thesis shows, the respective changes provided more comfort and protection to the
lenders and increased certainty in business transactions. In this way laws of security and
insolvency were elevated to new levels and this demonstrated the changing approach of
legislators and courts.
This originality of this work is in that it combines the study of the original Russian sources of
law with the perspective of financial transactions in the international markets. It also
includes a comparative element: where appropriate rules of Russian law are contrasted with
their counterparts in English law. Furthermore, Russian security and insolvency laws are
often reviewed through the prism of their practical application and effect on lending
practices. Thus, the link between law and economy is also exposed
PERENCANAAN DAN PENERAPAN PREVENTIVE MAINTENANCE MESIN CNC MILLING FZ 2000
No full textAn industrial internship is a practical activity for students with the aim of gaining experience from this activity, which can later be used for professional development and human resource development. One of the industrial internships was carried out at a bus body company from Ungaran, namely CV. Like Bodywork. During the industrial internship the author focused on research regarding the planning and implementation of Preventive Maintenance of ABS vacuum pumps on CNC Milling machines FZ 2000. Problems that occurred during the production process using CNC Milling machines with ABS Vacuum pumps were the problem of broken blades, the radiator not running properly. Well, there\u27s an electrical short circuit, the air hoses are leaking, the vacuum pump is leaking or overheating. Planning a maintenance system needs to be done to reduce the number of machine downtime. CV. Laksana Karoseri uses two types of maintenance systems, General Maintenance and Emergency Maintenance. Meanwhile, preventive maintenance activities carried out on the CNC MILLING FZ 2000 machine include daily maintenance, maintenance every 2 months, maintenance every 6 months and annual maintenance. Meanwhile, preventive maintenance on ABS vacuum engine pumps on CNC Milling Machines is known to be carried out every 6 months including checking and replacing the vacuum engine oil using 2 liters of Corena S4 P shell oil for every use reaching 5000 km/hour, cleaning the air filter, maintaining and cleaning the water filter and checking the spindle lubricating fluid
Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens
No full textThe nitrofuran antibacterial agent furazolidone (FZ) is still used in veterinary medicine in some countries in the Middle and Far East. The present study aimed to show the effect of FZ on the activity of microsomal enzymes that metabolize FZ, and to identify the enzyme that contributes to FZ metabolism in chickens. Wistar rats and White Leghorn chickens were administered FZ once a day for 4 consecutive days. FZ metabolism was accelerated by FZ administration in chickens, but not in rats. The elevation of FZ metabolism coincided with the induction of NADPH cytochrome P450 reductase (CPR) activity in chickens, but such induction was not observed in rats. FZ metabolizing activities were inhibited in the presence of a CPR inhibitor (diphenylene iodonium chloride) but not by the addition of archetypal cytochrome P450 inhibitors (CO or n-octylamine). The preset study concluded that FZ accelerated its own metabolism in the chicken by induction of the activity of CPR
Frizzled-Induced Van Gogh Phosphorylation by CK1ε Promotes Asymmetric Localization of Core PCP Factors in Drosophila
No full textSummaryEpithelial tissues are polarized along two axes. In addition to apical-basal polarity, they are often polarized within the plane of the epithelium, so-called Planar Cell Polarity (PCP). PCP depends upon Wnt/Frizzled (Fz) signaling factors, including Fz itself and Van Gogh (Vang/Vangl). We sought to understand how Vang interaction with other core PCP factors affects Vang function. We find that Fz induces Vang phosphorylation in a cell-autonomous manner. Vang phosphorylation occurs on conserved N-terminal serine/threonine residues, is mediated by CK1ε/Dco, and is critical for polarized membrane localization of Vang and other PCP proteins. This regulatory mechanism does not require Fz signaling through Dishevelled and thus represents a cell-autonomous upstream interaction between Fz and Vang. Furthermore, this signaling event appears to be related to Wnt5a-mediated Vangl2 phosphorylation during mouse limb patterning and may thus be a general mechanism underlying Wnt-regulated PCP establishment
Numerical investigation of FZ-growth of GaAs with encapsulant
No full textNumerical simulation of flow and heat transfer for a 3 in. (0.075 m) diameter liquid encapsulant full float zone (LEFZ) growth of single-crystal GaAs was conducted using the finite-element method. Convective and conductive heat transfers, radiative heat transfer between diffuse surfaces and the Navier–Stokes equations for both melt and encapsulant as well as the interface position are all combined and solved simultaneously. The effect of the thickness of encapsulant, rotation rate of crystal and feed rod on the flow and heat transfer as well as on the growing and melting interface shape were investigated
Spinon excitations in the spin-1 XXZ chain and hidden supersymmetry
No full textAbstractWe study spinon excitations of the integrable spin-1 (Fateev–Zamolodchikov; FZ) chain and their relation to the hidden supersymmetry. Using the notion of the supercharges earlier introduced to the spin chains, which change the system length by one, we found that they nontrivially act on one of two kinds of the degrees of freedom for the FZ chain. Their actions were obtained to be the same as those of the supercharges defined on the supersymmetric sine-Gordon model, the low-energy effective field theory of the FZ chain. Moreover, we construct the eigenstates which are invariant under the supersymmetric Hamiltonian given as the anti-commutator of the supercharges
Sexual maturity status as a confounding variable in fish-based screening assays for the detection of anti-estrogens and non-aromatizable androgens
No full textReproductive endocrine disrupting compounds (REDCs) in the environment pose a potential threat to fish, as exposures are capable of altering reproduction. Fish-based screening assays are utilized to screen for the presence of REDCs in surface waters and to assess single chemicals for potential endocrine activity. To improve such assays, the goal of this project was to determine whether less and more sexually mature females differed in their responses to the model anti-estrogen fadrozole (FZ) and the model androgen 17ß-trenbolone (TB). Less mature females were more sensitive to FZ and a high concentration of TB, while the more mature females were more sensitive to a low concentration of TB. The differential responses of these females indicate that maturity status influences REDC exposure outcome and should subsequently be taken into consideration in the implementation of screening assays
Long-term orbital period behaviour of contact binaries V343 Ori and FZ Ori
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYIn this study, we investigated orbital period variations of two contact binaries V343 Ori and FL Ori based on published minima times. Using the O-C analysis, it was found that both systems indicate orbital period increase. Mass transfer from less massive component to more massive component was used to explain increases in the orbital periods. On the other hand, the secular changes in their periods can be a sign of the thermal relaxation oscillation. In the O-C diagram of FL Ori, periodic variations also exist. Cyclic periodic changes can be explained as being the result of a light travel time effect via a tertiary body around the eclipsing pair. The minimum mass of probable tertiary component around FL Ori was found to be 0.63 M-circle dot. In addition, the cyclic variation may be evidence of magnetic activity of the components, which are late-type stars.Turkish Phys So
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