88,189 research outputs found
Welschland kontra Deutschland? Das Italienbild in Johann Gottfried Schnabels 'Cavalier'
No full textIl saggio analizza il romanzo di Johann Gottfried Schnabel 'Der Cavalier' del 1738, che racconta le avventure amorose di un giovane tedesco inviato in Italia dal padre per un 'viaggio di formazione'. Tema centrale del lavoro è l'immagine che dell'Italia si ha nei paesi di lingua tedesca a cavallo fra Seicento e Settecent, ma anche la concezione pedagogicao per la gioventù della media e piccola nobiltà, così come per i ceti borghesi più abbienti e intellettuali
My cavalier (el caballero)
No full textGift of Dr. Mary Jane Esplen.Piano vocal [instrumentation]Brave heart watching over me [first line]Who is my cavalier [first line of chorus]E-flat [key]Brilliant [tempo]Popular song ; [form/genre]Masked man holding fainting woman , hands holding swords [illustration]Blank pages on inside front and back cover [note]Partial dealer stamp on cover and full stamp on page 3 [note
Parallel mapping and simultaneous sequencing reveals deletions in BCAN and FAM83H associated with discrete inherited disorders in a domestic dog breed
No full textThe domestic dog (Canis familiaris) segregates more naturally-occurring diseases and phenotypic variation than any other species and has become established as an unparalled model with which to study the genetics of inherited traits. We used a genome-wide association study (GWAS) and targeted resequencing of DNA from just five dogs to simultaneously map and identify mutations for two distinct inherited disorders that both affect a single breed, the Cavalier King Charles Spaniel. We investigated episodic falling (EF), a paroxysmal exertion-induced dyskinesia, alongside the phenotypically distinct condition congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID), commonly known as dry eye curly coat syndrome. EF is characterised by episodes of exercise-induced muscular hypertonicity and abnormal posturing, usually occurring after exercise or periods of excitement. CKCSID is a congenital disorder that manifests as a rough coat present at birth, with keratoconjunctivitis sicca apparent on eyelid opening at 10-14 days, followed by hyperkeratinisation of footpads and distortion of nails that develops over the next few months. We undertook a GWAS with 31 EF cases, 23 CKCSID cases, and a common set of 38 controls and identified statistically associated signals for EF and CKCSID on chromosome 7 (P(raw) 1.9×10(-14); P(genome) = 1.0×10(-5)) and chromosome 13 (P(raw) 1.2×10(-17); P(genome) = 1.0×10(-5)), respectively. We resequenced both the EF and CKCSID disease-associated regions in just five dogs and identified a 15,724 bp deletion spanning three exons of BCAN associated with EF and a single base-pair exonic deletion in FAM83H associated with CKCSID. Neither BCAN or FAM83H have been associated with equivalent disease phenotypes in any other species, thus demonstrating the ability to use the domestic dog to study the genetic basis of more than one disease simultaneously in a single breed and to identify multiple novel candidate genes in parallel
Cavalier galopant la cravache au poing
No full text[Soldat vu de trois-quarts][Cavalier vu de dos et de trois-quarts, tourné vers la gauche]Référence bibliographique : Rosenberg Prat, 278bRéférence bibliographique : Rosenberg Prat, G45Référence bibliographique : Jean-Richard, 81Référence bibliographique : IFF18 JULLIENNE (Jean de), 15Référence bibliographique : IFF18 BOUCHER (François), 60Référence bibliographique : Prosper de Baudicour, Boucher (François), 8
L'Histoire du Vieux et du Noveau Testament : representée avec des figures et des explications édifiantes ...
No full textSign.: [], a-e, A-Z, 2A-2Z, 3A-3ZAntepPort. con grav. calc.: "Duflos f."Grav. calc. intercalados no texto: "Duflos f.
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Hepatic abscess and umbilical venous catheter: one cannot be cavalier about proper position
No full textPURPOSE The umbilical venous catheter (UVC) is routinely used in neonatal intensive care. Incorrect placement may expose the patient to some dangerous complications (i.e. thrombosis, abscesses, etc). We report a case of an hepatic abscess due to incorrect positioning of this device. We describe how the abscess was treated and we emphasize that one cannot be cavalier about proper positioning of the UV
Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: Transition state and the C-terminal function
No full textThe molecular basis of fructose-2,6-bisphosphatase (F-2,6-P 2ase) of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) was investigated using the crystal structures of the human inducible form (PFKFB3) in a phospho-enzyme intermediate state (PFKFB3-P•F-6-P), in a transition state-analogous complex (PFKFB3•AlF 4), and in a complex with pyrophosphate (PFKFB3•PP i) at resolutions of 2.45, 2.2, and 2.3 Å, respectively. Trapping the PFKFB3-P•F-6-P intermediate was achieved by flash cooling the crystal during the reaction, and the PFKFB3•AlF 4 and PFKFB3•PP i complexes were obtained by soaking. The PFKFB3•AlF 4 and PFKFB3•PP i complexes resulted in removing F-6-P from the catalytic pocket. With these structures, the structures of the Michaelis complex and the transition state were extrapolated. For both the PFKFB3-P formation and break down, the phosphoryl donor and the acceptor are located within ∼5.1 Å, and the pivotal point 2-P is on the same line, suggesting an in-line transfer with a direct inversion of phosphate configuration. The geometry suggests that NE2 of His253 undergoes a nucleophilic attack to form a covalent N-P bond, breaking the 2O-P bond in the substrate. The resulting high reactivity of the leaving group, 2O of F-6-P, is neutralized by a proton donated by Glu322. Negative charges on the equatorial oxygen of the transient bipyramidal phosphorane formed during the transfer are stabilized by Arg252, His387, and Asn259. The C-terminal domain (residues 440-446) was rearranged in PFKFB3•PP i, implying that this domain plays a critical role in binding of substrate to and release of product from the F-2,6-P 2ase catalytic pocket. These findings provide a new insight into the understanding of the phosphoryl transfer reaction. © 2011 Wiley Periodicals, Inc
Un cavalier arverne de l’aile des Voconces (CIL XIII, 3463)
No full textInternational audienceCette inscription est une épitaphe. Elle est datée du Ier siècle apr. J.-C., au plus tard de 89, date retenue par Géza Alföldy pour le transfert de l’aile des Voconces en Rhénanie, où elle remplace l’Ala I Flavia : …]us Secci f(ilius) Arvernu|s eques ala Vo(co)ntiorum |an(norum) XXV stipend(iorum) | VII h(ic) s(itus) est. “Ici repose (…), fils de Seccus, Arverne, cavalier de l’aile des Voconces, mort à 25 ans après 7 années de service.
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