1,721,222 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Neurochemical characterization of bortezomib-induced peripheral neuropathy: expression of TRPV1, CGRP and substance P in the rat DRG and dorsal horn of spinal cord
No full textBortezomib (BTZ), a selective ubiquitin-proteasome system inhibitor, is a potent antineoplastic drug to treat multiple myeloma. In clinical practice, a significant peripheral sensory neuropathy (PN),
generally associated with impairment of Aß, Ad, and C type primary afferent fibers, represent the most significant side effect of its administration. However, the mechanism underlying its harmful effects
remains still to be fully clarified.
In order to investigate the possible neurochemical changes involved in neuropathic pain development, we used a well-established rat model of BTZ-induced PN, whose hallmarks are allodynia,
neurophysiological and morphological alterations of myelinated and unmyelinated fibers of sciatic nerve. With this aim, by means of western blot (WB) and immunohistochemistry, we examined rat L4-L5
dorsal root ganglia (DRG) and spinal cord for their expression of the transient receptor potential vanilloid type-1 (TRPV1) and the sensory neuropeptides calcitonin gene-related peptide (CGRP) and
substance P (SP). In fact, TRPV1 is expressed by sensory neurons where it functions as a molecular integrator for nociception by causing release of CGRP and SP which, in turn, enhance the
sensitization of nociceptors.
WB showed that TRPV1 increased significantly in both DRG and spinal cord homogenates of BTZ-treated rats. In tissue sections, the proportion of DRG neurons expressing TRPV1 and CGRP was
higher, though not significantly, in BTZ-treated than in control animals, whereas SP neurons did not change. Morphometry showed that labelled neurons fell predominantly in the class of small- and
medium-sized cells. In the spinal cord an increase of TRPV1-, CGRP-LI nerve fibers and terminals occurred in the Lissauer's tract and superficial layers of the dorsal horn of BTZ-treated compared to
controls.
These observations will be useful to deeply understand the pathophysiology of the BTZ-induced neuropathic pain and allow potential more targeted therapies
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Coma, alterazioni della coscienza e sonno
No full textComa - Stato simile al sonno di protratta non responsività dal quale il paziente non può essere risvegliato con appropriati stimoli sensoriali.
- E’ la conseguenza di un insulto che interessa in maniera estesa gli emisferi cerebrali e/o la sostanza reticolare attivante.
- Le cause del coma sono ascrivibili a problemi di tipo strutturale (traumi, lesioni occupanti spazio, ischemia ed emorragia cerebrale) o non strutturale (cause infettivo-infiammatorie delle meningi e dell’encefalo, encefalopatie tossico-metaboliche, anossia).
- Tra un individuo in pieno stato di coscienza ed un paziente in coma profondo esiste un continuum di condizioni nelle quali può essere maggiormente compromesso lo stato di vigilanza, ossia il livello di coscienza piuttosto che il suo contenuto o viceversa
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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