86,812 research outputs found
Domenico Cavalca , Vite di Santi Padri .
No full textNumérisation effectuée à partir d'un document original.Appartient à l'ensemble documentaire : RegiaAragonVies des saints pères de l'Eglise rédigée par Dominicus Cavalca de Vico Pisano (ca. 1270-1342). Ce texte est composé en trois parties avec, entre autre, la vie de saint Paul (f. 1-5), de saint Antoine (f. 5-33), de saint Jean ermite (f. 48-57), de saint Appolonius (f. 57-63), de saint Amone (f. 64-71), de l'abbé Elie (f. 71-82), de l'abbé Macario (f. 89-93), de l'abbé Moise (f. 93-95) et du moine Valente (f. 95-96). F. 1-96 : "Incomincia la vita di sancto Paulo primo heremita et prima come per paura di certi pericolosi tormenti che si facevano a christiani fuggi al diserto. Nel tempp di Decio et Valeriano imperadori ...-... vidi I huomo iusto perire della sua iustitia et questo non e se non per la sua superbia". F. 96-136 : "Incominciasi la seconda parte delle vite de sancti padri nella quale si chiama paradiso scrpta ( sic ) da Eraclio el quale gran parte delli infrascripti santi visito ...-... li quali oragunavano o conservavano le riccheze con peccato et credonsi por fare pace condio con alcune elimosine che danno." F. 137-247 : "Incomincia el terzo libro et prima di santo Frontonio el quale abandono fi monastero della citta et ando a stare all heremo con pochi monaci...-... Finito el terzo e ultimo libro della vita de sancti Padri Deo gratias".Ce manuscrit a appartenu à la famille des Visconti-Sforza dont les armes ducales sommées de deux cimiers sont représentées au f. 1 (1-4 : aigle sur champ d'or des Sforza ; 2-3 : serpent sur champ d'argent des Visconti). Les initiales "H I P. M A." désignent Ippolita Maria , la fille de Francesco Sforza . Ce manuscrit est mentionné dans l'inventaire effectué à l'occasion du mariage de Ippolita avec Alphonse de Calabre , fils de Ferdinand I er d'Aragon et futur Alphonse II de Naples ("Le vite de sancti Padri, ducati XL"). Il intégre ensuite la bibliothèque des rois Aragonais de Naples . Au XVI e siècle, ce manuscrit appartient au cardinal Salviati (f. 2 : deux tampons, l'un rouge l'autre noir, de la bibliothèque de ce cardinal). Au XVIII e siècle, ce manuscrit appartient au pape Pie VI . A la fin du XIX e siècle, ce manuscrit est acquis à Naples par Rodolfo marchand d'antiquités et bourgeois de Francfort sur le Main. En 1886 , ce manuscrit est acquis Bibliothèque nationale de France
Free malondialdehyde (F-MDA): a plasmatic marker of clinical instability in coronary artery disease
No full textBackground: Macrophage derived proteolytic enzymes induce collagen catabolism, resulting in a weakened fibrous cap of coronary atherosclerotic plaques. The subsequent ulceration and endoluminal thrombosis may lead to unstable angina and myocardial infarction. Futhermore, macrophage activation is followed by the release of oxigen free radicals whose activity may be monitored by plasmatic concentration of free-malondialdehyde (F-MDA). Elevated F-MDA values are considered suggestive of a rising rate of macrophage-mediated lipid peroxidation. v Aim: To evaluate F-MDA as a marker of macrophage activation and, then, of plaque and clinical instability. Methods: We enrolled 15 pts with stable angina (SA), 22 with unstable angina (UA) and 12 with myocardial infarction (AMI). Patients were well-matched for age, sex and coronary risk factors. F-MDA was assessed by gas chromatography-mass spectrometry Data were analysed using Wilcoxon test and χ2 test. Results: F-MDA was significantly higher in patients with UA and AMI when compared with SA group (0.58μM and 0.65μM vs 0.31μM, as median values p<0.01). F-MDA was over the normal range (0-0.35μM) in 4 pts with SA (26%), 17 with UA (77%) and 9 with AMI (75%) (p<0.02). No relation was found between F-MDA concentration and lipids, CRP and ESR. (Graph Presented) Conclusions: Our study shows the "in vivo" role of activated macrophages in acute coronary syndromes. F-MDA might be useful to identify patients at risk of instabilisation
OXY-SCORE : a global index to improve evaluation of oxidative stress by combining pro- and antioxidant markers
No full textOur group recently proposed OXY-SCORE, a summary index of oxidative stress, computed by combining plasma free and total malondialdehyde (F- and T-MDA), glutathione in disulphide/reduced forms (GSSG/GSH), α- and γ-tocopherol (TH), urine isoprostanes (iPF2α-III) levels, and plasma individual antioxidant capacity. Here, we describe the methods for the determination of the analytes and for the computation of the scores. We also report the results of two studies testing the performances of OXY-SCORE, and showing its value in assessing the oxidative status of cardiovascular patients and healthy subjects
Le teorie della fine del lavoro, ideologie e provocazioni
No full textThe “End of work” theories targeted the transition towards a digital and service society stating the end of full employment, widespread prosperity and endless economic development. The increase of unemployment and the (historically recurrent) fear of new technologies inspired theoretical attempts to identify a new era in substitution of the Industrial Society revolved around the ‘abstract labour’. Beyond the ideology arguing (without being able to demonstrate) the complete technological displacement and the consequent dawn of a Jobless Society and beyond the provocation of overstating the effects of the digital transition, scholars as Rifkin, Meda, Beck, and others, contributed to draft a new pattern of Capitalism where labour is still central but unstable and unable to guarantee social rights and identity
A proposed new comprehensive index of oxidative stress: Oxiscore
No full textObjective: Oxidative stress has been related both to the aging process and to several pathologies, like cancer and cardiovascular disease. Up to now, no ideal biomaxker for oxidative stress is available. This study was performed to identify a comprehensive index of oxidative status (OXISCORE)reflecting both injuries and antioxidant defences in vivo.
Methods: We enrolled and stratified by age and gender, 87 healthy subjects (59% males; age 24-77) and 20 CAD patients (65% males; age 47-81). Plasma free and total malondialdehyde (F- and T-MDA), glutathione
disulphide/reduced forms (GSSG/GSH) and urine isoprostane (iPF2alpha-III)levels were measured as markers of oxidative damage, and computed in the damage score (DS). Plasma glutathione, alpha- and gamma-tocopherol (TH)
levels, and individual antioxidant capacity (IAC), were measured as indexes of
antioxidant defence, and computed in the protection score (PS). OXISCORE was computed by subtracting PS from DS.
Results: In healthy subjects, only MDA was associated with age; only GSH, GSSG/GSH ratio and alpha-TH correlated with gender. OXISCORE,was positively associated with both age (p=0.007) and male gender (p=0.01).
Interestingly, OXISCORE was significantly higher in CAD subjects even after
adjusting for age and gender (p=0.0001).
Conclusions: No single parameter fully reflects the redox status. By representing
both antioxidant and oxidative systems, the OXISCORE provides a comprehensive index of oxidative stress related to age, gender and CAD status.
Funding: Grant from Italian Ministry of Healt
Amplified ribosomal DNA restriction analysis for the characterization of <i>Azotobacteraceae</i>: a contribution to the study of these free-living nitrogen-fixing bacteria
No full textA 16S rRNA gene-based fingerprinting method was developed for the identification of Azotobacteraceae and tested onto 48 soil isolates and 28 reference strains belonging to the free-living nitrogen-fixing bacterial group and to the most common species found in soil samples. According to this method, the 16S rRNA gene was amplified using universal primers for Eubacteria and PCR products were subsequently digested with RsaI, HhaI, HpaII, FnuDII, and AluI. The analysis of the restriction profiles obtained showed that the method is able to define a unique species-specific phylotype (SSP) for each of the eight Azotobacteraceae species tested. Cluster analysis was successfully employed for the identification of members of the family Azotobacteraceae, being assignation into species of the isolates confirmed by means of partial 16S rRNA gene sequencing
Bacterial-assisted adsorption technology for arsenic removal from water (BATA)
No full textThe health of millions of people world-wide is at risk due to the use of drinking arsenic-contaminated water. Furthermore the use of contaminated tube wells as irrigation source is generating worldwide concern on As accumulation and mobilization in agricultural topsoil. In recent years, a range of inexpensive, iron-based, water clean-up technologies have been developed to address the major problem of As-rich drinking water. Pilot studies based on the use of ZVI are randomly presented in literature and most of them are based on short term experiments, hence there is need of increase knowledge on ZVI performance to remove As on long term basis and to evaluate the influence of different parameters (water chemistry, system hydraulic, As speciation) on material performance and to assess ecological impact of the proposed technology. The possible use of AsIII oxidising bacteria has been investigated as effective oxidation step overcoming drawbacks of chemical oxidation in biofilter studies coupled with As removal treatment based on Fe adsorbents. The survey of study sites and sampling will be conducted according to operative indications of ARPALombardia. Speciation of As will be carried out by Ion Chromatography in combination with ICP-MS and iron speciation will be determined on site by spectrophotometric methods. Description of functional bacterial communities in As rich waters will be performed by a metagenomic approach using specific molecular probes for genes coding for enzymes involved in arsenic, iron and sulfur cycles. Biodiversity and phylogeny of the genes present in different samples will be evaluated by Next generation bar-coded sequence technologies. New indigenous AsIII oxidising strains will be isolated and characterised according to phenotypic and molecular methods. AsIII oxidising activity will be evaluated also in the presence of organic and inorganic pollutants eventually recovered in ground waters. The most effective bacteria will be produced at large scale in a 60 L-bioreactor in order to be used in lab- and pilot-scale experiments. These treatments will be conducted with different iron-based adsorbing materials. Long term studies will be conducted considering physic-chemical parameters that affect removal performance. The choice of “environment friendly” coatings will be considered to extend the ironmaterial duration and the use of AsIII oxidizing selected bacteria will be included to improve the efficiency of the proposed process. Based on results and on expertise acquired, innovative strategies will be proposed for the implementation of a pilot scale process for arsenic removal from ground waters
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