163,054 research outputs found
J. I. Catto. — The History of the University of Oxford. I : The Early Oxford Schools, 1984
No full textJ. I. Catto. — The History of the University of Oxford. I : The Early Oxford Schools, 1984. In: Cahiers de civilisation médiévale, 30e année (n°118), Avril-juin 1987. p. 195
J. I. Catto. — The History of the University of Oxford. I : The Early Oxford Schools, 1984
No full textJ. I. Catto. — The History of the University of Oxford. I : The Early Oxford Schools, 1984. In: Cahiers de civilisation médiévale, 30e année (n°118), Avril-juin 1987. p. 195
Comment on "On higher order corrections to gyrokinetic Vlasov-Poisson equations in the long wavelength limit" [Phys. Plasmas 16, 044506 (2009)]
No full textA recent publication [F. I. Parra and P. J. Catto, Plasma Phys. Controlled Fusion 50, 065014 (2008)] warned against the use of the lower order gyrokinetic Poisson equation at long wavelengths because the long wavelength, radial electric field must remain undetermined to the order the equation is obtained. Another reference [W. W. Lee and R. A. Kolesnikov, Phys. Plasmas 16, 044506 (2009)] criticizes these results by arguing that the higher order terms neglected in the most common gyrokinetic Poisson equation are formally smaller than the terms that are retained. This argument is flawed and ignores that the lower order terms, although formally larger, must cancel without determining the long wavelength, radial electric field. The reason for this cancellation is discussed. In addition, the origin of a nonlinear term present in the gyrokinetic Poisson equation [F. I. Parra and P. J. Catto, Plasma Phys. Controlled Fusion 50, 065014 (2008)] is explained. © 2009 American Institute of Physics
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Reply to Andrea Necchi, Antonella Messina, and Alberto Briganti's Letter to the Editor re: Valeria Panebianco, Yoshifumi Narumi, Ersan Altun, et al. Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting and Data System). Eur Urol 2018;74:294-306
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NEW HYBRID COUMARIN–SUBSTITUTED ALICYCLIC AMINES AS POTENTIAL MULTITARGET DIRECT LIGANDS FOR THE TREATMENT OF ALZHEIMER’S DISEASE
No full textIn order to achieve disease-modifying therapies for the treatment of Alzheimer’s disease (AD), the well-known
multitarget directed ligands (MTDL) approach was adopted to ensure synergistic action on multiple drug targets
by a single molecule. For this purpose, we designed and synthesized twenty new hybrids consisting of the
coumarin nucleus and substituted alicyclic amines (donezepil-like piperazino and piperidino derivatives), linked
by an alkyl chain of variable length in position 4- and 7- of the coumarin.
The coumarin nucleus has various biological activities (antioxidant, ChEs and MAO-B inhibitor) useful in
neuroprotection [1]. In addition, the basic fragment ensures affinity for ChEs and, if an aromatic ring (phenyl or benzyl) is present, anti-aggregating activity on β-amyloid could be found [2].
All compounds have been tested for their antioxidant activity trough the colorimetric DPPH assay. The
inhibition of human acetylcholinesterase (hAChE) and equine serum butyrylcholinesterase (esBChE) was
determined through the Ellman assay at the concentration of 10 μM and the IC50 was then determined for the
most active compounds.
All tested compounds show a weak antioxidant activity, mainly due to the coumarin system but lower than that
of the starting compounds due to functionalization of the hydroxyl group. Compounds with n = 4 have a higher
antioxidant activity than compounds with n = 3. The enzyme inhibition results show, however, that all
compounds are able to inhibit at least one of the two enzymes. The best IC50 of the tested compounds are
strongly encouraging with values between 0.31±0.06 and 6.05±0.59 μM for hAChE and between 2.08±0.38 and
19.6±2.0 μM on esBChE.
In conclusion, a moderate selectivity for AChE is observed and the 7-substitution provides better inhibitory
activity. The benzyl on piperazine leads to greater inhibition, while the length of the alkyl linker decreases the
activity on AChE whereas it appears to increase it on BChE.
These positive outcomes justify further studies on the inhibitory capacity of β-amyloid aggregation and MAO-B.
References
1) Pisani, L.; Catto, M.; Muncipinto, G.; Nicolotti, O.; Carrieri, A.; Rullo, M.; Stefanachi, A.; Leonetti, F.; Altomare, C. A Twenty-Year Journey Exploring Coumarin-Based Derivatives as Bioactive Molecules. Front. Chem. 2022, 10, 1002547.
https://doi.org/10.3389/fchem.2022.1002547.
2) Tasso, B.; Catto, M.; Nicolotti, O.; Novelli, F.; Tonelli, M.; Giangreco, I.; Pisani, L.; Sparatore, A.; Boido, V.; Carotti, A.; Sparatore, F. Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Potent Inhibitors of Acetyl- and Butyrylcholinesterase with Potential in Alzheimer’s Disease. Eur. J. Med. Chem. 2011, 46 (6), 2170–2184. https://doi.org/10.1016/j.ejmech.2011.02.071
Endoparasitos de animais domésticos e silvestres do Pantanal: helmintos, acantocéfalos, pentastomídeos e protozoários.
No full textRESUMO - Na primeira metade do século XIX, o naturalista Natterer coletou endoparasitos de répteis, mamíferos, aves e peixes na região de Cuiabá, MT. Esse material originou algumas das primeiras descrições de parasitas no Brasil por Diesing e Rudolphi. O primeiro registro de doenças parasitárias em animais domésticos na região do Pantanal foi feito em 1933, quando se relatou alta mortalidade, pelo mal-de-cadeira, em eqüinos. Somente quase um século após Natterer, novas coletas de endoparasitos de animais silvestres foram realizadas, na região, por Travassos, e, após essas descrições, pouco tem sido acrescentado sobre a endofauna parasitária de animais no Pantanal. As 61 espécies de répteis, peixes, aves e mamíferos dessa região, examinadas até o momento, estavam parasitadas, em média, com 2,2 espécies de parasitos. No entanto, nas três espécies de hospedeiros mais estudadas (bovinos, capivaras e jacarés), a média é de 20 espécies de parasitos/hospedeiro. Considerando que na região ocorrem cerca de 80 espécies de mamíferos, 350 de aves, 260 de peixes e 50 de répteis, pode-se afirmar que a endofauna parasitária dos vertebrados no Pantanal está, ainda, em sua maior parte, por ser identificada. ABSTRACT - In the first half of last century, the naturalist Natterer collected parasites of reptiles, mammals, birds and fish in the region of Cuiabá. That material originated some of the first descriptions of parasites in Brazil for Diesing and Rudolphi. The first registration of parasitic diseases in domestic animals in the Pantanal was in 1933, when it was told high mortality, for the mal-de-cadeiras, in equine. Only almost one century after Natterer, new collections of endoparasites of wild animals were accomplished in the area by Travassos. After the descriptions of Travassos little it has been increased on the parasitic endofauna of animals in the Pantanal. The 61 species of reptiles, fish, birds and mammals of the Pantanal examined to the moment were parasited, on average, with 2,2 species of parasites. However, in the three species of hosts more studied (bovine, capybaras and alligators) the average is of 20 parasites/host. Considering that in the region occurs about 80 species of mammals, 350 of birds, 260 of fish and 50 of reptiles can be affirmed that the parasitic endofauna of the vertebrates in the Pantanal is still for being identified
Gyrokinetic equivalence
No full textWe compare two different derivations of the gyrokinetic equation: the Hamiltonian approach in Dubin D H E et al (1983 Phys. Fluids 26 3524) and the recursive methodology in Parra F I and Catto P J (2008 Plasma Phys. Control. Fusion 50 065014). We prove that both approaches yield the same result at least to second order in a Larmor radius over macroscopic length expansion. There are subtle differences in the definitions of some of the functions that need to be taken into account to prove the equivalence. © 2009 IOP Publishing Ltd
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