1,720,979 research outputs found
Role of multiparametric magnetic resonance and ultrasound-guided/MR fusion biopsy in patients with low-risk prostate cancer suitable for active surveillance
No full textBACKGROUND: To evaluate the impact of multiparametric magnetic resonance (mpMR) and fusion biopsy in patients with low-risk prostate cancer suitable for active surveillance (AS) in order to reduce cases of disease downstaging.
METHODS: Between January 2016 and February 2018, 97 mpMRs were performed in patients with clinical indications for AS; the mpMR results were expressed using the PIRADS (Prostate Imaging Reporting and Data System) v2.1 score. Of the patients with equivocal or suspicious findings (PIRADS ≥3), 26 underwent transrectal ultrasound/MR fusion biopsy; the histological results were analysed and correlated to the MR data.
RESULTS: Multiparametric magnetic resonance documented benign findings (i.e. PIRADS 1-2) in 42/97 patients (43.3%) while, in the remaining 55/97 (56.7%), abnormal findings were found: 39/97 (40.2%) PIRADS 3, 14/97 (14.4%) PIRADS 4 and 2/97 (2.1%) PIRADS 5. Twenty-six patients underwent fusion biopsy (17 with PIRADS 3, 7 with PIRADS 4, 2 with PIRADS 5); in 17/26 (65.4%), a Gleason Score ≥7 was found and, in particular, in 10/17 (58.8%) of the PIRADS 3, 5/7 (71.4%) of the PIRADS 4 and 2/2 (100%) of the PIRADS 5.
CONCLUSIONS: More than half of the patients in AS showed MR abnormalities and the risk of upstaging increased as the PIRADS score increased; fusion biopsy allowed clarifying the importance of the MR findings, identifying a more aggressive prostate tumour in a high percentage of cases (65.4%). Therefore, MR with fusion biopsy should be proposed for all patients in AS for a correct diagnostic classification
Incremento dell’attività di RM multiparametrica della prostata: esperienza di un centro a elevato volume di attività
No full textOBIETTIVO: Analizzare l’incremento di attività di Risonanza Magnetica multiparametrica (RMmp) nella valutazione dei pazienti con tumore prostatico (CaP).
METODI: Sono state catalogate le RMmp eseguite in un periodo di 25 mesi secondo le indicazioni cliniche (diagnosi, stadiazione, sorveglianza attiva e follow-up dopo trattamento primario). Sono stati valutati: i reperti PIRADS (Prostate Imaging Reporting and Data System) v. 2, nella diagnosi; la presenza di estensione extra-capsulare (EEC) ed infiltrazione delle vescicole seminali (IVS), nella stadiazione; la conferma di malattia indolente oppure l’upgrade radiologico, nella sorveglianza attiva; la presenza di recidiva locale, nel follow-up. Per tutti questi valori sono stati riportati i dati di incremento assoluti e percentuali.
RISULTATI: Sono state effettuate 1034 RMmp della prostata con incremento del 341%. Le indicazioni erano così suddivise: diagnosi (73%), stadiazione (9%), sorveglianza attiva (13%) e follow-up (5%). Nella diagnosi, i risultati in termini di PIRADS erano: categorie 1 e 2 (69%), categoria 3 (19%), categorie 4 e 5 (12%). Nella stadiazione, EEC era presente in 26 su 94 (28%) e IVS in 10 su 94 (11%) pazienti. Nella sorveglianza attiva, la RMmp ha confermato una malattia indolente in 66 su 138 (48%) pazienti e ha dimostrato un upgrade radiologico in 72 su 138 (52%) pazienti. Nel follow-up, la RMmp ha dimostrato recidiva locale in 20 su 52 (38%) pazienti.
CONCLUSIONI: I risultati di questo studio hanno dimostrato un notevole incremento dell’attività di RMmp nell’arco di 25 mesi per tutte le indicazioni cliniche ed in particolare nella diagnosi, in cui essa viene usata sempre più come screening, e nella sorveglianza attiva, sebbene in questo contesto il suo ruolo non sia ancora chiaramente stabilito
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
