1,721,047 research outputs found
Preliminary thermal optimization and investigation of the overall structural behaviour of the EU-DEMO water-cooled lead lithium left outboard blanket segment
Full text linkThe conceptual design phase of the EU-DEMO reactor has been recently launched, with the aim of evolving the DEMO pre-conceptual layout towards a more robust and articulated geometric configuration able to cope with most of the design requirements and to show further margins for the passing of the current potential show-stoppers. Hence, the achievement of the conceptual design of the Water-Cooled Lead Lithium Breeding Blanket (WCLL BB) is one of the milestones the EUROfusion consortium aims to achieve in the close future. To this purpose, within the framework of the research activities promoted by EUROfusion, a research campaign has been launched at the University of Palermo, in close cooperation with ENEA-Brasimone, in order to investigate, from the thermal and thermomechanical standpoints, the WCLL BB Left Outboard Blanket (LOB) segment performances. The scope of the analysis carried out has been the advancement of the WCLL LOB segment design in view of the prescribed thermal and structural design requirements. To this end, the nominal WCLL BB operating conditions as well as accidental steady-state scenarios derived from the in-box loss of coolant accident and the upper vertical plasma disruption event have been considered. In the first part of the study, the internal Double-Walled Tubes (DWTs) layout of the WCLL LOB equatorial region have been preliminarily optimized so to find a geometric configuration able to cool the segment structure maintaining the maximum temperature below the suggested limit of 550 °C. Then, a purposely set-up analytical procedure has allowed obtaining a set of interpolating functions able to accurately reproduce the calculated thermal field and to extrapolate it to the whole WCLL LOB segment. Afterwards, the thermo-mechanical analysis of the entire segment has been performed under the selected loading scenarios. The structural behaviour of the segment has been assessed in compliance with the RCC-MRx code, adopting the set of criteria on the basis of the nature of the considered loading scenario. The obtained results, herewith presented and critically discussed, have allowed introducing significant design improvements with respect to the WCLL LOB segment reference geometric layout, coming from the pre-conceptual design phase, paving the way for future, and more detailed, structural investigations
Biochemical approaches to characterize targets responsible for acrylamide-induced inhibition of topoisomerase II
No full textVinyl monomer acrylamide (AA), generally used in numerous industrial applications, has been classified by the International Agency for Research on Cancer (IARC) as “probably carcinogenic to humans” (group 2A), but the molecular mechanism underlying its genotoxicity has not fully known.
Previously, we observed that Acrylamide (AA) was able to antagonize in vivo the citotoxicity of well know poison etoposide suggesting that topoisomerase II (Topo II) activity was affected by AA.
In the current studies we investigated the inhibitory activity of acrylamide toward topoisomerase II by performing tests in vitro
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Analysis of the Thermo-Mechanical Behaviour of the EU DEMO Water-Cooled Lithium Lead Central Outboard Blanket Segment under an Optimized Thermal Field
Full text linkWithin the framework of the EUROfusion research activities on the DEMO Water-Cooled Lithium Lead (WCLL) Breeding Blanket (BB) design, a research study was performed to preliminarily optimize, from the thermal point of view, the WCLL Central Outboard Blanket (COB) segment in order to investigate its structural behaviour under a realistic thermal field. In particular, a study of thermal analyses was performed to optimize the Double Walled Tubes and Segment Box cooling channels’ geometric configurations along the poloidal extension of the WCLL COB segment, in order to obtain a spatial temperature distribution fulfilling the thermal design requirement. Then, the thermo-mechanical analysis of the WCLL COB segment under Normal Operation (NO, representing nominal conditions), Upper Vertical Displacements Event (UVDE, representing a plasma disruption event) and Over-Pressurization (OP, representing an in-box loss of coolant accident) scenarios were carried out, assuming the previously obtained thermal field, to realistically predict displacement and stress fields. Finally, a stress linearization procedure allowed comparing the stress values obtained in some critical regions of the structure with the criteria prescribed by the reference design standard RCC-MRx. A theoretical–numerical approach based on the Finite Element Method (FEM) was followed using the commercial code Abaqus v. 6.14
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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