19 research outputs found
Golfoploop en golfoverslag bij dijken
No full textDit verslag is een aangepaste versie van het gelijknamige verslag uit 1993. Het verslag geeft een samenvatting van nieuwe resultaten met betrekking tot golfoploop en golfoverslag bij dijken. Het verslag geeft hiervoor ontwerp- of toetsformules. Verschillende invloeden zijn door middel van reductiefactoren in de formules verwerkt. Dit zijn de invloeden van een berm, ruwheidselementen op het talud, scheve golfaanval, zowel langkammige als kortkammige golven en van een (verticale) wand op het talud. De golfoploop kan als functie van de brekerparameter worden beschreven. Golfoverslag wordt in twee formules gegeven, één voor brekende golven met een maximum voor niet-brekende golven. Verder is een verdeling gegeven voor overslagvolumes per golf.Golfoploop en Golfoverslag - TAW/EN
Effects of Shielding Gas Contamination on Aluminium Weid Porosity
No full textApplied SciencesTechnische Materiaalwetenschappe
Piezoresponse force microscopy of BaTiO3-chitosan and BaTiO3-polyethylene glycol nanocomposites
No full textThe work was funded by Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica-CONCYTEC according to agreement at Sub project 072–2018–FONDECYT–BM–IADT–AV.Influence of surface modification of barium titanate nanoparticles of spherical shape with the average size of 200 nm in ferroelectric tetragonal crystal phase on the value of piezoelectric response by piezoelectric force microscopy has been studied. It has been found that the modification of the surface of nanoparticles with organic molecules for the increasing of biocompatibility leads to a decrease in the value of effective piezo response from 150 to 48–60 pm/V. At the same time, it is possible to switch polarization in the investigated samples. This allows to consider the mentioned nanocomposites to be promising materials for diagnostics and treatment of cancer tumors, as well as creation of new generation implants accelerating the osteogenesis process. © 2021, The Author(s), under exclusive licence to The Materials Research Society.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte
The margin and the mainstream : positioning Harry Partch's theories within the broader discourse of musical aesthetics
No full textBibliography: leaves 102-106.The dissertation examines the broader musical value of microtonal composer Harry Partch's musical theories by locating his critique of abstract music within mainstream compositional theory and aesthetics. This contextualisation aims to deconstruct Partch's iconoclastic image so as to understand his contribution within a wider realm of critical discourse. The work of composers that follow in Partch's footsteps becomes important in this context, especially that of his one-time student Ben Johnston whose own microtonal aesthetic is firmly rooted in European aesthetics from Debussy to Schoenberg. By a study of Johnston's utilisation of Partch's theory of just intonation the dissertation attempts to arrive at a more inclusive compositional theory, one which continues to address those aspects of Partch's theories that serve as a valid and constructive critique of traditional musical values. Taking Adorno's view that musical critique must deal with the problem of reification at the level of musical materials, the author proposes a reading of Partch's corporeal philosophy that is applicable beyond the confines of narrative musical drama. By creating a distinction between historical models of organisation and 'second nature' forms of musical presentation, it is suggested that critique does not necessarily prefigure alienation from the mainstream, but can rather be situated within musical discourse in such a way that a new image of the latter's forms results. On a practical level, the dissertation explores the validity of expanded just intonation as a means of achieving this immanent critique, both in the realm of compositional theory and, implicitly, in that of analytical theory, concluding with the description of a tuning system with the capacity to synthesise the range of compositional theories explored
An assessment of the quantum for financial provision of mine closures: a Monte Carlo approach.
No full textIncludes abstract.Includes bibliographical references.Poor mine closure policy threatens both society and the environment. Some of the more prominent threats that have manifested are acid mine drainage, slimes dams and toxic dust from dumps. Current legislation requires that new mines set aside funds to cover their rehabilitation costs at closure
Recent developments in protein-ligand affinity mass spectrometry
No full textThis review provides an overview of direct and indirect technologies to screen protein-ligand interactions with mass spectrometry. These technologies have as a key feature the selection or affinity purification of ligands in mixtures prior to detection. Specific fields of interest for these technologies are metabolic profiling of bioactive metabolites, natural extract screening, and the screening of libraries for bioactives, such as parallel synthesis libraries and small combichem libraries. The review addresses the principles of each of the methods discussed, with a focus on developments in recent years, and the applicability of the methods to lead generation and development in drug discovery. © The Author(s) 2010
Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures
No full textIn the screening of complex mixtures, for example combinatorial libraries, natural extracts, and metabolic incubations, different approaches are used for integrated bioaffinity screening. Four major strategies can be used for screening of bioactive mixtures for protein targets-pre-column and post-column off-line, at-line, and on-line strategies. The focus of this review is on recent developments in post-column online screening, and the role of mass spectrometry (MS) in these systems. On-line screening systems integrate separation sciences, mass spectrometry, and biochemical methodology, enabling screening for active compounds in complex mixtures. There are three main variants of on-line MS based bioassays: the mass spectrometer is used for ligand identification only; the mass spectrometer is used for both ligand identification and bioassay readout; or MS detection is conducted in parallel with at-line microfractionation with off-line bioaffinity analysis. On the basis of the different fields of application of on-line screening, the principles are explained and their usefulness in the different fields of drug research is critically evaluated. Furthermore, off-line screening is discussed briefly with the on-line and at-line approaches. © The Author(s) 2010.
Studying protein–protein affinity and immobilized ligand–protein affinity interactions using MS-based methods.
No full textThis review discusses the most important current methods employing mass spectrometry (MS) analysis for the study of protein affinity interactions. The methods are discussed in depth with particular reference to MS-based approaches for analyzing protein-protein and protein-immobilized ligand interactions, analyzed either directly or indirectly. First, we introduce MS methods for the study of intact protein complexes in the gas phase. Next, pull-down methods for affinity-based analysis of protein-protein and protein-immobilized ligand interactions are discussed. Presently, this field of research is often called interactomics or interaction proteomics. A slightly different approach that will be discussed, chemical proteomics, allows one to analyze selectivity profiles of ligands for multiple drug targets and off-targets. Additionally, of particular interest is the use of surface plasmon resonance technologies coupled with MS for the study of protein interactions. The review addresses the principle of each of the methods with a focus on recent developments and the applicability to lead compound generation in drug discovery as well as the elucidation of protein interactions involved in cellular processes. The review focuses on the analysis of bioaffinity interactions of proteins with other proteins and with ligands, where the proteins are considered as the bioactives analyzed by MS. [Figure not available: see fulltext.] © 2011 The Author(s)
Evaluation of the causes implicated in fermentation delay and complete fermentation failure during the manufacture of "Mozzarella di Bufala"
No full textAuthor Correction: Transmural collaborative care model for the review of antipsychotics: a feasibility study of a complex intervention (Scientific Reports, (2024), 14, 1, (12367), 10.1038/s41598-024-62349-9)
No full textCorrection to: Scientific Reportshttps://doi.org/10.1038/s41598-024-62349-9, published online 29 May 2024 The original version of this Article contained an error in Figure 3, where the number of participants who missed their follow-up was incorrect. The original Figure 3 and accompanying legend appear below. (Figure presented.) Distribution of QRISK3 score at baseline. The original Article has been corrected
