88,332 research outputs found
Automated flow cytochemistry in measuring chronic lymphocytic leukemia- and healthy adult cells
No full textLymphocyte size measured by automated flow cytochemistry mayhave prognostic implication in chronic B-lymphocytic leukemia
Efficient Design of Differentiated Reliability (DiR) Optical Ring networks with low demand outage
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Comparative results of the mitogenic effects of polyclonal B-cell activators in different stages of chronic lymphocytic leukemia
No full textIn order to correlate the mitogenic response pattern of cultured lymphocytes with different polyclonal activators (PMA, LPS, SA, PHA-M) and clincal stage of the disease, the expression of cytoplasmic Ig, secr tion of Ig, modal cell volume, la antlgen, acid phosphatase activity and mitotic ndex were measured following culture twenty three consecutive patients wlth B-cell.
The results showed that patients with advanced Ral clinical stages (III and IV) presented a more heterogenous stimulatory pattern, depending on the severity of their disease and mitoyen employed. Furthermore, whlle PHA-M appeared to be the most efflcient stimulator in the initial Rai stages of CLL, showing a close correlatîon with the high percentage of blood T celle, LPS mitogen was able to induce an optimal dlfferential pattern in terminal Rai stages only. However, in spite of the differences observed in the patients at different stages of the disaease, a consistent number of stlmuiated celle was found wlth all tested mitogens. Thls report suggests that a global evaluation of the attivation of the neoplastlc B•cell clone in B-CLL, should be achieved by the use of multiple polyclonal B-celt activators
Basophil count in samples from chronic leukaemia patients analysed by the automated flow cytochemistry technology
No full textIn this paper, it is demonstrated that a careful analysis of the basophil cytogram from patients with chronic lymphocytc leukemia may give rise to an easy discrimination between true and false basophilia , even without requiring the benefit of a microscopic examination
Potential clinical applications of rhGM-CSF in acute myeloid leukemia based on its biological activity and receptor modulation
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