2,023 research outputs found
α-Amino-α ́-halomethylketones: Synthetic Methodologies and Pharmaceutical Applications as Serine and Cysteine Protease Inhibitors
No full texta-Amino-a ́-halomethylketones are interesting scaffolds bearing (at least) two sequential electrophilic carbons that by interacting with the nucleophilic moieties of several enzymes, represent the ideal candidates for in vivo and in vitro inhibition studies. In this work a summary of their use as optimal inhibitors of physiologically relevant serine and cysteine proteases is given with a particular emphasis on recently established SAR studies. A brief survey of the most relevant synthetic processes for their obtainment and the importance they possess in synthetic medicinal chemistry is reported
Giovanni Pascoli, l'arte medievale e l'Estetismo europeo
No full textL'articolo intende sfatare il luogo comune sul presunto provincialismo e indifferenza, o scarsissima competenza, di Pascoli riguardo a tutto ciò che di nuovo e soprattutto internazionale si muove nei rapporti tra poesia e arti visive in Italia a fine Ottocento, attraverso il suo epistolario, le sue letture, le sue riflessioni critiche e soprattutto la sua opera poetic
Per una storia critica delle vicende del confine orientale
No full textIl saggio discute alcuni aspetti della storia del confine orientale italiano nel '900 sui quali più frequenti sono state le semplificazioni e gli equivoci interpretativi. I principali nodi affrontati riguardano il nesso continuità/rottura, la questione della violenza politica, quella dei rapporti fra i movimenti di liberazione italiano e jugoslavo ed infine il tema della comparazione sia diacronica che sincronica: fra i due dopoguerra nell'area alto-adriatica e con altre storie di frontiera europee
Recuerdos de Massimo.
No full textEl presente ensayo recuerda la rica relación personal e intelectual entre Massimo Pavarini e Iñaki Rivera Beiras desde que el segundo conoció siendo muy joven a Pavarini. En ese sentido, el trabajo recuerda los inicios de su fecunda relación en la ciudad de Bologna cuando Iñaki Rivera acudía a presentar a Massimo Pavarini los desarrollos de lo que sería su tesis doctoral. Las contribuciones de Pavarini al proceso de aprendizaje de Rivera, en el terreno de una epistemología crítica en la penología contemporánea, son analizados como un homenaje a la memoria y a la obra del autor italiano, tras su fallecimiento en septiembre de 2015.This paper recalls the rich personal and intellectual relationship between Massimo Pavarini and Iñaki Rivera Beiras. In that sense , the work recalls the beginning of his fruitful relationship in the city of Bologna when Iñaki Rivera came to present Massimo Pavarini’ developments in what would be his PhD thesis. Pavarini contributions to the learning process of Rivera, on the ground of a critical epistemology in contemporary penology , are analyzed as a tribute to the memory and to the work of Italian author, after his death in September 2015 .El presente ensayo recuerda la rica relación personal e intelectual entre Massimo Pavarini e Iñaki Rivera Beiras desde que el segundo conoció siendo muy joven a Pavarini. En ese sentido, el trabajo recuerda los inicios de su fecunda relación en la ciudad de Bologna cuando Iñaki Rivera acudía a presentar a Massimo Pavarini los desarrollos de lo que sería su tesis doctoral. Las contribuciones de Pavarini al proceso de aprendizaje de Rivera, en el terreno de una epistemología crítica en la penología contemporánea, son analizados como un homenaje a la memoria y a la obra del autor italiano, tras su fallecimiento en septiembre de 2015
Romantico per ragione e per fede
No full textIntroducendo la nuova edizione critica dell’implorante scritto manzoniano, l’A. analizza, le modifiche subite dalla lettera nella forma originale inviata al marchese d’Azeglio al momento della sua inserzione nella raccolta cumulativa delle Opere del 1870-71: modifiche non vistose, ma assai significative del precisarsi e in parte del mutarsi, nell’arco di vari decenni, della poetica del grande scrittore
Predoni a casa nostra e il geografo solidale: Massimo Quaini tra terra e acqua
No full textIn accordance with the main goals of this collection of essays in honour of Massimo Quaini, the text focuses on a peculiar character of the Ligurian geographer’s sensibility, his attention to landscape protectionresearch activity developed in the context of the humanistic geography. Starting from a personal narrative based on his own reminiscences and neglected memories, the author tries to shed light on the relationships between civil commitment and cultural reflection which characterize environmental sensitivity, bringing together his interests with Quaini’s emotional geographies. Finally, some of Quaini’s everyday practicalities are highlighted as the easiest doorway to improve the cognitive procedures of cultural geography
Il "bravo italiano" e il "cattivo tedesco". Stereotipi nazionali e costruzione di una memoria europea
No full textIl saggio analizza la costruzione della coppia di stereotipi "cattivo tedesco" e "bravo italiano" realizzata in Italia fra il 1943 e il 1947 da parte delle elités politiche e culturali interessate a distinguere le responsabilità italiane da quelle tedesche per ottenere un trattamento benevolo al tavolo della pace da parte dei vincitori
Is Felix Salten the author of the Mutzenbacher novel (1906)? Yes and no
No full textJosefine Mutzenbacher oder die Geschichte einer Wienerischen Dirne von ihr selbst erzählt, published in Vienna in 1906, represents one of the most fascinating cases of attribution of authorship in German literature. Although Josefine Mutzenbacher is usually attributed to Felix Salten, the author of the world-famous Bambi (1923), the novel’s authorship has never been confirmed, and many other candidates have been named as potential authors. Among them is Arthur Schnitzler, who published Reigen, a cycle of amorous adventures in Viennese society, in 1903. Some scholars, instead, have attributed the novel to such lesser-known writers as Ernst Klein and Willi Handl. The controversy surrounding the authorship of Josefine Mutzenbacher was the starting point for our stylometric analyses, and our results help to answer some unresolved questions in a debate that has lasted for more than 100 years. The analyses were performed using the R package Stylo, which enables an efficient application of Burrows’ Delta and its variants. Focusing on both the entire text and on the final pages, two different types of analysis were carried out: one combines 1200 different stylometric methods to compare the candidate authors Salten, Schnitzler, Bahr, Altenberg, Hofmannsthal, Klein and Handl; the other verifies the attribution using the ‘impostors’ method. The results show that the most probable author is Felix Salten, while none of the candidates could be identified as the author of the final pages, confirming the hypothesis that the text was left unfinished by Salten and completed by an as-yet-unidentified ghost-writer
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