1,720,989 research outputs found

    PD-L1 alternative splicing

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    PhD thesis of Dr Yashu Zhen, graduated in 2022. All data in thesis pertains to this project. Publication being put together with these data and new experiments being finished

    Excel file with DEGs for Lorenzini et al (Roca) RNA 2019

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    DEGs and other gene expression data from RNA-seq data. 7 RNA-seq samples for K562 cells, PRPF40B knockout and rescue with WT or MDS mutant PRPF40B. Excel file with all the Differentially Expressed Genes (DEGs). Significant DEGs labeled 'Yes', others 'No'

    Excel file with DASEs for Lorenzini et al (Roca) RNA 2019

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    7 RNA-seq samples for K562 cells, PRPF40B knockout and rescue with WT or MDS mutant PRPF40B. Excel file with Differential Alternative Splicing Events (DASEs) from RNA-seq data using rMATS.. Only events that pass the cutoffs

    Big Heegner points and special values of L-series

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    In Longo and Vigni (Manuscr Math 135:273–328, 2011), Howard’s construction of big Heegner points on modular curves was extended to general Shimura curves over the rationals. In this paper, we relate the higher weight specializations of the big Heegner points of Longo and Vigni (Manuscr Math 135:273–328, 2011) in the definite setting to certain higher weight analogues of the Bertolini–Darmon theta elements (Bertolini and Darmon in Invent Math 126:413–456, 1996). As a consequence of this relation, some of the conjectures in Longo and Vigni (Manuscr Math 135:273–328, 2011) are deduced from recent results of Chida and Hsieh (J Reine Angew Math, 2015)

    Variation of anticyclotomic Iwasawa invariants in hida families

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    Building on the construction of big Heegner points in the quaternionic setting by Longo and Vigni, and their relation to special values of Rankin–Selberg Lfunctions established by Castella and Longo, we obtain anticyclotomic analogues of the results of Emerton, Pollack and Weston on the variation of Iwasawa invariants in Hida families. In particular, combined with the known cases of the anticyclotomic Iwasawa main conjecture in weight 2, our results yield a proof of the main conjecture for p-ordinary newforms of higher weights and trivial nebentypus

    On the Iwasawa theory of elliptic curves at Eisenstein primes

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    These are expanded notes for the mini-course given by the author at the 2022 ICTS workshop `Elliptic curves and the special values of LL-functions'

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Generalised Kato classes on CM elliptic curves of rank 2

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    Let E/QE/\mathbf{Q} be a CM elliptic curve and let p5p\geq 5 be a prime of good ordinary reduction for EE. Suppose that L(E,s)L(E,s) vanishes at s=1s=1 and has sign +1+1 in its functional equation, so in particular ords=1L(E,s)2{\rm ord}_{s=1}L(E,s)\geq 2. In this paper we slightly modify a construction of Darmon--Rotger to define a generalised Kato class κpSel(Q,VpE)\kappa_p\in{\rm Sel}(\mathbf{Q},V_pE), and prove the following rank two analogue of Kolyvagin's result: κp0dimQpSel(Q,VpE)=2. \kappa_p\neq 0\quad\Longrightarrow\quad{\rm dim}_{\mathbf{Q}_p}{\rm Sel}(\mathbf{Q},V_pE)=2. Conversely, when dimQpSel(Q,VpE)=2{\rm dim}_{\mathbf{Q}_p}{\rm Sel}(\mathbf{Q},V_pE)=2 we show that κp0\kappa_p\neq 0 \emph{if and only if} the restriction map Sel(Q,VpE)E(Qp)^Qp {\rm Sel}(\mathbf{Q},V_pE)\rightarrow E(\mathbf{Q}_p)\hat\otimes\mathbf{Q}_p is nonzero. The proof of these results, which extend and strenghten similar results of the author with Hsieh in the non-CM case, exploit a new link between the nonvanishing of generalised Kato classes and a main conjecture in anticyclotomic Iwasawa theory.Comment: 26 pages, revised version following a referee's repor
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