1,721,075 research outputs found
Den Digitale Agora:Episode 1: Casper Steinmann
No full textI denne podcast kan du møde Casper Steinmann, der er lektor ved Institut for Kemi og Biovidenskab. Casper har stor erfaring i at arbejde med Moodle, AAU’s LMS (Learning management system). Casper benytter Moodle til at tjekke ind med sine studerende i løbet af forelæsningerne og dermed tilpasse dem løbende. Casper har utroligt mange spændende vinkler på det at undervise, så derfor har vi delt dette afsnit op i tre dele. I den første hører vi Casper tale om sit arbejde med Moodle, i andet er der fokus på brug af videoer i undervisningen og produktion af videoerne og i tredje og sidste del kan du høre om hvordan Casper laver problembaseret gamification af sin undervisning
Den Digitale Agora:Episode 1: Casper Steinmann
No full textI denne podcast kan du møde Casper Steinmann, der er lektor ved Institut for Kemi og Biovidenskab. Casper har stor erfaring i at arbejde med Moodle, AAU’s LMS (Learning management system). Casper benytter Moodle til at tjekke ind med sine studerende i løbet af forelæsningerne og dermed tilpasse dem løbende. Casper har utroligt mange spændende vinkler på det at undervise, så derfor har vi delt dette afsnit op i tre dele. I den første hører vi Casper tale om sit arbejde med Moodle, i andet er der fokus på brug af videoer i undervisningen og produktion af videoerne og i tredje og sidste del kan du høre om hvordan Casper laver problembaseret gamification af sin undervisning
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Exploring the mechanisms and properties of Auvelity through computational chemistry
No full textThe aim of this thesis was to determinethe binding site and mechanismof action of the novel therapeuticdrug Auvelity, a mixture of Dextromethorphanand Bupropion, on theN-methyl-D-aspartate receptor. Thiswas achieved by applying computationalchemistry methods. The thesis focusedon the antagonist Dextromethorphan,and the methods used included moleculardocking, molecular dynamics simulations,and molecular mechanics generalizedBorn surface area calculations.Computational analyses revealed, thatDextromethorphan binds to the aminoterminal domain of the receptor with abinding affinity of −10.2kcal/mole. Vander Waal was the primary binding force,alongside electrostatic forces. Thesefindings were compared to that of a wellknown antagonist, Ketamine, and theresults showed similarities in both bindingaffinity and interaction forces. Thesimulations further determined, that Ketaminewould also bind to the aminoterminal domain, which indicated, thatboth Dextromethorphan and Ketaminewould regulate the receptor through allostericmodulation
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A computational workflow for binding free energies in Python
No full textThe literature show that -cyclodextrin (-CD) have good probabilities of forming inclusion complexes in water with ligands having a low solubility themselves, both \textit{in situ} and \textit{in silico}. Through Python, the framework OpenMM was used together with OpenFF (developers of the SMIRNOFF force fields (FF)) to simulate such inclusion complexes in water with Molecular Dynamics (MD). SMIRNOFF uses so-called direct chemical perception, in opposition to older FF like AMBER, to parameterise molecules directly from the chemical graph by the use of SMIRKS. SMIRKS are able to recognise patterns in molecules, making the process more efficient.The goal of the MD simulations was to introduce a biasing potential between the -CD and a ligand and by measuring the distance between the two molecules in each snapshot, finding the free binding energy of the inclusion complex. Through Umbrella Sampling (US) and analyses by FastMBAR, a software tool for applying the Bennet Acceptance Ratio, it was shown that OpenMM was indeed a viable option in this regard. Through the analyses, it was revealed that a sample size of 2000 snapshots per window in the US and a bin size of 20 per window, both the free energy and standard deviations converged. Comparisons with the literature showed that the method was feasible although some of the free energies of the inclusion complexes were a bit high
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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