361 research outputs found
Appendix_1_included_studies – Supplemental material for Mental health interventions among older adults: A systematic review
No full textSupplemental material, Appendix_1_included_studies for Mental health interventions among older adults: A systematic review by Janni Niclasen, Lisbeth Lund, Carsten Obel and Lars Larsen in Scandinavian Journal of Public Health</p
Prenatal antidepressant exposure and child behavioural outcomes at 7-years of age
No full textAbstract 312Luke E Grzeskowiak, Janna L Morrison, Tina B Henriksen, Bodil H Bech, Jorn Olsen, Carsten Obel, Lars H Pederse
Complex treatment of invasive corticotropic pituitary macroadenoma - Case report
No full textObel Michał, Nowicka Emilia, Dzikowski Piotr, Pietrzak Zofia, Stefaniak Martyna, Obel Ewa. Complex treatment of invasive corticotropic pituitary macroadenoma - Case report. Journal of Education, Health and Sport. 2022;12(7):347-356. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.07.033
https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.07.033
https://zenodo.org/record/6795160
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.06.2022. Revised: 20.06.2022. Accepted: 04.07.2022.
Complex treatment of invasive corticotropic pituitary
macroadenoma - Case report
Michał Obel, Emilia Nowicka, Piotr Dzikowski, Zofia Pietrzak, Martyna Stefaniak,
Ewa Obel
Michał Obel1, [email protected];
https://orcid.org/0000-0003-1237-8732
Emilia Nowicka1, [email protected];
https://orcid.org/0000-0002-2743-1551
Piotr Dzikowski2, [email protected];
https://orcid.org/0000-0002-6335-9171
Zofia Pietrzak2, [email protected];
https://orcid.org/0000-0001-8469-6225
Martyna Stefaniak2, [email protected];
https://orcid.org/0000-0002-8036-8379
Ewa Obel3, [email protected]
https://orcid.org/0000-0003-2961-8843
1. Student‘s Scientific Association at the Department of Endorinology of the Medical University of Lublin
2. Student‘s Scientific Association at the Chair and Department of Epidemiology of Medical University of Lublin
3. Department of Endorinology of the Medical University of Lublin
Abstract:
Introduction: Cushing's disease is a hypercortisolemic state caused by the excess secretion of corticotropin by the pituitary adenoma. Cushing's disease is diagnosed on the basis of clinical and laboratory signs of hypercortisolemia and the presence of an MRI pituitary adenoma. Pituitary surgery represents the first-line therapy, but it is non-curative in one third of patients, requiring additional treatments. Second-line treatments include pharmacotherapy, pituitary radiotherapy and bilateral adrenalectomy.
Keywords: macroadenoma; Cushing diseas; hypercortisolemi
Thyrotropinoma - the case report about one of the rarest type of pituitary adenomas
No full textJarosz Piotr M., Idzik Zuzanna, Gołacki Jakub, Obel Ewa. Thyrotropinoma - the case report about one of the rarest type of pituitary adenomas. Journal of Education, Health and Sport. 2022;12(4):25-33. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.04.002
https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.04.002
https://zenodo.org/record/6420088
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 25.03.2022. Revised: 25.03.2022. Accepted: 07.04.2022.
Thyrotropinoma - the case report about one of the rarest type of pituitary adenomas
Piotr M. Jarosz [1], Zuzanna Idzik [1], Jakub Gołacki [1], dr n. med. Ewa Obel [2]
1. Students Scientific Association at Department of Endocrinology, Medical University of Lublin, Chodźki Street 19, 20-093 Lublin, Poland
2. Department of Endocrinology, Medical University of Lublin, Jaczewskiego Street 8,
20-090 Lublin, Poland
Piotr M. Jarosz; [email protected]; ORCID: 0000-0003-0489-2600;
Zuzanna Idzik; [email protected]; ORCID: 0000-0001-7678-2545;
Jakub Gołacki; [email protected]; ORCID: 0000-0001-8502-3030;
Ewa Obel; [email protected]; ORCID: 0000-0003-2961-8843;
Abstract
Pituitary tumours are a significant diagnostic problem in clinical practice. Considering all the rarity of thyrotropic hormone secreting adenoma it is a diagnostic and therapeutic challenge in part due to the lack of the preoperative standards. TSH-oma, besides hyperthyroidism symptoms, might be a cause of other endocrine disorders, most often dysfunction of other tropic axes and may cause neurological symptoms associated with sella expansion. We report a case of a 49-year-old male patient with macroadenoma, overt clinical hyperthyroidism, secondary adrenal insufficiency and hypogonadotropic hypogonadism. The diagnosis of thyrotropinoma was confirmed by blood tests that revealed elevated FT3 and FT4 levels together with high TSH. Thyrotropin-releasing hormone (TRH) test was performed and magnetic resonance imaging (MRI) imaging revealed the presence of macroadenoma. Histopathology examination confirmed the diagnosis of thyrotropic cell pituitary adenoma. The appropriate therapy for thyrotropin pituitary adenoma has not been elaborated in reports of this domain. Preoperatively the patient was prepared by long-acting somatostatin analogue (Sandostatin LAR) injections to reduce tumor size with good therapeutic effect afterwards underwent surgical transsphenoidal treatment successfully. However, specific treatment guidelines for pituitary thyrotropic tumors need to be elaborated more in details.
Key words: thyrotropinoma; secondary hyperthyroidism; somatostatin analogue; case report
Am J Med Genet A
No full textToday, most persons with Down syndrome (DS) survive into middle age, but information on their social conditions as adults is limited. We addressed this knowledge gap using data from national registers in Denmark. We identified a national cohort of 1,998 persons with DS who were born between 1968 and 2007 (1,852 with standard trisomy 21, 80 with Robertsonian translocations and 66 with mosaicism) using the Danish Cytogenetic Register. We followed this cohort from 1980 to 2007. Information on social conditions (education, employment, source of income, marital status, etc.) was obtained by linkages to national registers, including the Integrated Database for Longitudinal Labor Market Research. For those aged 18 and older, more than 80% of persons with DS attended 10 years of primary school, with about 2% completing secondary or post-secondary education. About 4% obtained a full-time job, whereas the remaining mainly received public support from the government. Only a few (1-2%) of persons with DS were married or had a child. No significant differences in these social conditions were seen between males and females. More persons with mosaic DS attended secondary or post-secondary education, had a full-time job, were married, or had a child (18%, 28%, 15%, and 7%, respectively), compared with persons with standard DS (1%, 2%, 1%, and 1%, respectively). These data may provide families with better insight into social conditions and society with a better understanding of the social support needed for persons with DS.5 U10 DD000230-06/DD/NCBDD CDC HHS/United StatesSKR9/Intramural CDC HHS/United State
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