48,689 research outputs found
Introductions to Persian Philosophy, Indian Philosophy, Buddhist Philosophy, Chinese Philosophy, Japanese Philosophy and Islamic Philosophy
No full text
Hepatocellular Carcinoma as a Paradigm for a Systemic Evolutionary Approach to Cancer
No full textThe systemic evolutionary theory of cancer pathogenesis posits that cancer is generated by the de-emergence of the eukaryotic cell system and by the reappearance of its ancestral subsystems, the archaea (genetic material and cytoplasm) and the prokaryote (mitochondria), which operate autonomously or uncoordinatedly. This unpaired coordination can be caused by changes in the eukaryote environment, mainly inflammation, damage to mitochondrial DNA or to mitochondrial membranes by viruses, chemicals, hydrogenated fatty acids in foods, and damage to nuclear DNA controlling mitochondria energy production or metabolic pathways including glycolysis. Here, we propose that an “energy package” is constantly required by the cell to maintain its differentiated status. When the energy flow works normally, the two subsystems, the archaea and the prokaryote, are perfectly integrated and there is no prevalence of one system on the other, so that cellular differentiation is maintained. However, as a consequence of a long-lasting injury (e.g. chronic inflammation), the energy at tissue level is restricted and this may cause, over time, the gradual decoupling of the two subsystems with the “prokaryote” subsystem that becomes predominant. The cirrhotic liver represents a paradigmatic scenario whereby this process may occur, due to altered vascular bed, fibrosis and reduction of the oxygen availability. The prevalence of the “prokaryote” subsystem may explain the metabolic alterations seen in liver cancer cells as well as the capacity for proliferation and invasion, especially toward areas of major oxygen availability (e.g. arterialization of portal vein in the liver). This approach highlights the notion that tissue integrity is essential for the proper flow and availability of energy for the maintenance of cellular homeostatic functions
Santo Tomas leave pass for W. Carr Hooper
No full textThis leave pass dated March 1, 1945 was issued to W. Carr Hooper from Santo Tomas Internment camp in Manila, Philippines where Carr and his wife Ruth were interned from January 1942 to February 1945. On the back is written "Sec B." The camp, also known as the Manila Internment Camp, was run by the Japanese military during World War II and housed over 3,000 internees from January 1942 until February 1945.World War I
Communication and Languageless Creatures
No full textThe essays in this collection were written to mark the occasion of D. J. O'Connor's 75th birthday
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Of a the airts the wind can blow, I dearly love the west [first line]
No full textstrophicpiano and voice580Johns Hopkins University, Levy Sheet Music Collection, Box
036, Item 032A popular Scotch Song Written By Burns. With an accompaniment for the Piano Forte by B. Carr
On the deck of the slow sailing vessel alone as I silently sat [first line]
No full textstrophicpiano and voice; fluteJohns Hopkins University, Levy Sheet Music Collection, Box
038, Item 149Words by J.H. Payne. Music by B. Carr
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