1,721,035 research outputs found
The neurodevelopmental continuum towards a neurodevelopmental gradient hypothesis
Full text linkIn contrast to the categorical approach of the current nosographic system, in the last decades increasing literature is suggesting that psychiatric disorders may be better conceptualized as a continuum, which would feature as a common basis a neurodevelopmental alteration. The “neurodevelopmental continuum” (NC) is a theoretical framework supported by several empirical evidences in multiple fields of research. The conceptual core of this model is that an alteration in brain development, the expression of which would be determined by the intertwined relationships between genetic and environmental factors, may constitute the common underpinning of different kinds of mental disorders. Moreover, the NC theory also implies that psychiatric conditions could be placed along a gradient, where autism spectrum disorder (ASD) with intellectual disabilities would be the most severe expression of an alteration of the “social brain development”, followed by other DSM-5 neurodevelopmental phenotypes characterized by a milder impairment. This model would subsequently include, along a decreasing neurodevelopmental gradient, other psychiatric conditions such as schizophrenia and mood disorders as well as eating and anxiety disorders, encompassing also non-psychopathological personality traits. From a cognitive point of view, the link between neurodevelopmental alterations and vulnerability towards psychopathology could be identified in an impairment of the proprioceptive experience and of the interoceptive inference, which would prevent the patient to properly define his own subjectivity and to adequately place him-self in the relational space. The conceptual framework proposed here may allow significant changes in both research and clinical settings, eventually leading to improve therapeutic and prevention strategies
Oxidative stress, maternal diabetes, and autism spectrum disorders
Full text linkAutism spectrum disorders (ASD) are a group of early-onset neurodevelopmental conditions characterized by alterations in brain connectivity with cascading effects on neuropsychological functions. To date, in the framework of an increasing interest about environmental conditions which could interact with genetic factors in ASD pathogenesis, many authors have stressed that changes in the intrauterine environment at different stages of pregnancy, such as those linked to maternal metabolic pathologies, may lead to long-term conditions in the newborn. In particular, a growing number of epidemiological studies have highlighted the role of obesity and maternal diabetes as a risk factor for developing both somatic and psychiatric disorders in humans, including ASD. While literature still fails in identifying specific etiopathological mechanisms, a growing body of evidence is available about the presence of a relationship between maternal immune dysregulation, inflammation, oxidative stress, and the development of ASD in the offspring. In this framework, results from high-fat diet animal models about the role played by oxidative stress in shaping offspring neurodevelopment may help in clarifying the pathways through which maternal metabolic conditions are linked with ASD. The aim of this review is to provide an overview of literature about the effects of early life insults linked to oxidative stress which may be involved in ASD etiopathogenesis and how this relationship can be explained in biological terms
Autistic traits and illness trajectories
Full text linkIn the framework of increasing attention towards autism-related conditions, a growing number of studies have recently investigated the prevalence and features of sub-threshold Autistic Traits (ATs) among adults. ATs span across the general population, being more pronounced in several clinical groups of patients affected by psychiatric disorders. Moreover, ATs seem to be associated with specific personality features in non-clinical population, implying both a higher vulnerability towards psychopathology and extraordinary talents in specific fields. In this framework, the DSM-5’s Autism Spectrum Disorder (ASD) presentations may be considered as the tip of an iceberg that features several possible clinical and non-clinical phenotypes. Globally, the autism spectrum may be considered as a trans-nosographic dimension, which may not only represent the starting point for the development of different psychopathological trajectories but also underlie non-psychopathological personality traits. These different trajectories might be shaped by the specific localization and severity of the neurodevelopmental alteration and by its interaction with the environment and lifetime events. In this wider framework, autistic-like neurodevelopmental alterations may be considered as a general vulnerability factor for different kinds of psychiatric disorders, but also the neurobiological basis for the development of extraordinary abilities, eventually underlying the concept of geniality. Moreover, according to recent literature, we hypothesize that ATs may also be involved in the functioning of human mind, featuring the peculiar sense of “otherness” which can be found, with different grades of intensity, in every human being
Camouflaging: Psychopathological meanings and clinical relevance in autism spectrum conditions
No full textIn the last decade, increasing literature focused on camouflaging as a strategy adopted to cope with social environment by subjects with Autism spectrum disorder (ASD). A better understanding of this phenomenon may shed more light on cognitive mechanisms and coping strategies of subjects in the autism continuum, eventually leading to reconsider some previous "dogmas" in this field, such as the gender's discrepancy in ASD diagnosis. Moreover, shared features can be observed in the camouflaging strategies adopted amongst the general population, amongst subjects of the autism spectrum and amongst patients with different kinds of psychiatric disorders, further challenging our perspectives. Camouflaging behaviours might be considered as a transdiagnostic element, closely associated with the continuous distribution of the autism spectrum amongst the general and the clinical population
A comprehensive perspective of autistic traits and catatonic symptoms in a patient with Fronto-Temporal Dementia and Bipolar Disorder: a case report
No full textBackground: Fronto-Temporal Dementia (FTD) is a neurodegenerative disorder featuring frontotemporal lobe atrophy which leads to profound changes in behavior and cognition in the affected subjects. Considering that the onset of this type of dementia is typically characterized by the development of affective symptoms, differential diagnosis between FTD and Bipolar Disorder (BD) is particularly difficult. An important overlapping feature between BD and FTD is the presence of catatonic symptoms: Catatonia is extremely frequent in FTD, and, on the other hand, BD is the psychiatric disease with the highest frequency of association with catatonic states. In this framework, it should be noted that also Autism Spectrum conditions have been reported to show high rates of comorbidity and overlapping features with BD. In addition, subjects with autistic traits were reported to show an increased vulnerability towards the development of mood and anxiety disorders, as well as increase the risk of mood episodes with mixed features, suicidal thoughts and catatonic symptoms. Case presentation: We reported the case of a patient with a diagnosis of both BD and FTD who showed catatonic symptoms. Objectives: The aim of this case report is to evaluate the possible role of autistic traits in the illness trajectory of BD and FTD. Conclusion: This case confirms the presence of a continuum between psychiatric and neurological conditions, which should be considered as expressions of a same neurobiological system and further investigated in light of an integrative model
POST TRAUMATIC GROWTH (PTG) IN THE FRAME OF TRAUMATIC EXPERIENCES
No full textThe psychopathological consequences of traumatic experiences have been object of study from the beginning of medical science. During the last centuries, the scientific literature in the field of mental health mainly focused on the negative consequences of traumatic events. More recently, increasing interest was paid to the features of resilience and to the possible positive consequences of trauma, leading to the concept of Post Traumatic Growth (PTG). However, the eventual co-existence of both the conditions should also be considered. The role of vulnerability and environmental factors in the balance between positive and negative outcomes after life events is discussed, particularly in light of a neurodevelopmental approach to psychopathology
Avenging Lamarck: the role of epigenetic in modulating reactions to traumatic events
No full textPost Traumatic Growth and Post-Traumatic Stress disorder represent two parallel phenomena whose origin is a common ground, trauma. Following the Lamarck theory, recent epigenetic studies seem to confirm the importance of gene-environment interaction in determining different reactions to traumatic events that, according to the concept of Historical Trauma and Post-Traumatic Slave Syndrome, could interfere with the entire course of lives of a family and/or of a cultural group, becoming intergenerational. Recently, a growing field of research has focused on the associations between epigenome and mental illnesses, also including autism spectrum disorder (ASD), reporting a possible higher vulnerability to epigenetic alterations, in ASD subjects. Indeed, a greater neurobiological and genetic vulnerability to environment influences in association with the deficit in interaction and understanding of social stimuli make ASD subjects more easily exposed to trauma. On the other hand, these subjects, compared to neurotypical people, may more frequently develop positive reactions, thanks to divergent thinking that allows them to adopt a new point of view following stressful events. In this framework, the epigenome represents a new key to understand the impact on highly challenging events on illness trajectories and their role in mental disorders
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
- …
