1,720,958 research outputs found
Osteonecrosis of the jaw and bisphosphonate: prevention, diagnosis and treatment
No full textIntroduzione: L'osteonecrosi dei mascellari nei pazienti in terapia con bisfosfonati (ONJ-BF) rappresenta un problema
medico multidisciplinare che ha suscitato notevole interesse sia in ambito nazionale che internazionale. Negli ultimi anni
sono comparse nel mondo sempre più numerose segnalazioni di osteonecreosi dei mascellari insorte in pazienti trattati
con BF.
Obiettivi: Nonostante i numerosi studi scientifici ed epidemiologici, i punti oscuri sono moltissimi ed ancora non si è
riusciti a fare completa chiarezza nell'approccio clinico da adottare in presenza di pazienti in terapia con questi farmaci.
Nel presente lavoro verrà eseguita una disamina dell’eziopatogenesi, degli elementi diagnostici e delle diverse modalità
terapeutiche da poter adottare nei confronti di tale fenomeno clinico.
Metodi: L'intervento odontoiatrico sembra aumentare la frequenza di una ONJ-BF, tuttavia è possibile che una
preesistente ONJ-BF in forma subclinica si manifesti come patologia dentaria o, in alternativa, che l’estrazione o
l’intervento odontoiatrico sveli una sottostante osteonecrosi.
Risultati: In condizioni normali si assisterebbe ad una guarigione rapida senza sequele infettive, anche se il cavo orale
non è un ambiente sterile. Nei soggetti che sviluppano ONJ-BF la guarigione è invece lenta e difficoltosa, con tendenza
alla contaminazione della lesione ossea con germi della flora batterica del cavo orale.
Conclusioni: Le complesse implicazioni cliniche e medico-legali impongono a tutti gli operatori sanitari, odontoiatri,
igienisti dentali, chirurghi orali e maxillo-facciali, una adeguata conoscenza dei processi diagnostici e dei principi generali
di prevenzione di tale patologia.Background: Osteonecrosis of the jaws in patients treated with bisphosphonates (ONJ-BF) is a multidisciplinary medical
problem that has aroused considerable interest. In recent years several reports of osteonecrosis of the jaws in patients
treated with BF have appeared.
Objectives: Despite numerous scientific and epidemiological studies, a lot of doubts still persist and it is currently not
possible to make significant progress in clarifying the clinical approach to patients using ONJ-BF. Our paper wants to
offer a review about the mechanism and the elements of the various diagnostic and therapeutic modalities that can be
used against this clinical phenomenon.
Methods: Dental procedures seem to increase the frequency of ONJ-BF, but it is possible that a preexisting subclinical
ONJ-BF appears as a dental disease or, alternatively, that the extraction or dental procedures reveal a half hidden
osteonecrosis.
Results: In normal conditions, this could rapidly heal without infectious con
Iperplasia reattiva infiammatoria del labbro superiore, causata da malposizione dentale. Caso clinico
No full text
Cleidocranial Dysplasia: Maxillary Alterations on the Transverse Plane. Presence of Crown-radicular Anomalies and Multidisciplinary Approach of a Clinical Case.
No full textIntroduction: Cleidocranial Dysplasia (CCD) is a rare inherited autosomal dominant congenital syndrome that occurs in approximately one out of every one million individuals worldwide; it primarily affects bones that undergo intra-membranous ossification, generally the skull and clavicles. Other bones may be affected such as the long bones, spine, pelvis, bones of hands and feet showing hypoplasia of distal phalanges. Indispensable is the role of the gene Runx2, necessary for the differentiation of odontoblasts and osteoblasts; it regulates the expression of many genes related to the development of dental hard tissues. The aim of this study was to appraise the connection between the Cleidocranial Dysplasia and the appearance of skeletal and dental anomalies not much deepen to this day. With particular emphasis, it wants to describe the multidisciplinary therapeutic approach. Case Report: The patient showed multiple skeletal features of CCD. A distinctive feature was the failed or delayed exfoliation of deciduous dentition and a delayed eruption of permanent teeth. The goal of the treatment is the improvement of both aesthetic and functional aspects. This objective can be achieved through an appropriate multidisciplinary treatment plan that arranges the orthodontic and surgical measures. Results and Discussions: Because of the involvement of facial bones, the altered mode of tooth eruption and the presence of numerous included supernumerary teeth, CCD is a pathology that all dentists should be familiar with. The patients have small faces compared to the skull and the hypoplasia of maxillary, tear, nasal and zygomatic bones. The orthodontic approach in literature seems to be reduced to the guided eruption of bad-positioned and impacted teeth. Knowledge of the clinical features of CCD allows for the early planning of the procedures necessary to resolve the dental pathologies observed in CCD patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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