697 research outputs found
Miranda_Open_Practices_Disclosure – Supplemental material for Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives
No full textSupplemental material, Miranda_Open_Practices_Disclosure for Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives by Robert Miranda, Stephanie E. Wemm, Hayley Treloar Padovano, Ryan W. Carpenter, Noah N. Emery, Joshua C. Gray and Ethan H. Mereish in Clinical Psychological Science</p
Identification and Reactivity of Cyclometalated Iron(II) Intermediates in Triazole-Directed Iron-Catalyzed C–H Activation
No full textIntermediates in base metal catalysis for organic transformations : cross-coupling and C-H functionalization
No full textThesis (Ph. D.)--University of Rochester. Department of Chemistry, 2019.
"Chapter 1: Professor Michael L. Neidig co-wrote this review article" -- Pages xvIron and cobalt are attractive catalysts for numerous organic transformations due to
the accessibly, low cost, and low toxicity of these transition metals. More importantly,
these metals can undergo a variety of oxidation states, leading to highly reactive
intermediates. While these metals are used in various cross-coupling and C-H
functionalization reactions, the mechanisms of these various reactions are unique to the
system. Despite the effectiveness for catalysis, iron and cobalt catalysts are typically poorly
understood. In fact, complete characterization of these intermediates requires the use of a
multifaceted physical-inorganic approach in order to probe the electronic structure,
bonding, and reactivity of these highly unstable complexes. Chapter 1 focuses on this
physical-inorganic methodology in order to probe reaction mechanisms of iron-catalyzed
cross-coupling systems. Here, previous reports are used to show the significance of this
methodology, and background information into the physical methods utilized are
explained. Chapter 2 explores simple iron salt catalyzed cross-coupling reactions involving
aryl Grignard reagents and alkyl halides. These systems have been known to work poorly
in comparison to similar reactions utilizing alkyl Grignard reagents. However, upon
targeting highly reactive species in situ, the aryl systems can be highly reactive to form
cross-coupled product. Chapter 3 explores cobalt speciation in reactions involving an
additive, simple cobalt salts, and alkyl Grignard reagents. The corresponding iron systems
have been previously explored in depth and have shown to produce several iron-methyl
species. In this chapter, a novel cobalt-methyl species is characterized. Chapter 4 focuses
on the elucidation of the mechanism for iron-catalyzed directed C-H functionalization reactions. Several reactions with the same general motif exist, though, there are many
different outcomes of these reactions (amination, allylation, and phenylation). Using the
physical-inorganic methodology described in chapter 1, it was found that the various C-H
functionalization systems produce similar reaction intermediates despite differences in
bisphosphine ligands and benzamine substrates. By directing reactions to form specific iron
intermediates, the reactions can be controlled to produce various new C-C and C-N bonds
Novel mathematical modeling approaches to assess ischemic stroke lesion evolution on medical imaging
No full textStroke is a major cause of disability and death worldwide. Although different clinical
studies and trials used Magnetic Resonance Imaging (MRI) to examine patterns of
change in different imaging modalities (eg: perfusion and diffusion), we still lack a clear
and definite answer to the question: “How does an acute ischemic stroke lesion grow?”
The inability to distinguish viable and dead tissue in abnormal MR regions in stroke
patients weakens the evidence accumulated to answer this question, and relying on static
snapshots of patient scans to fill in the spatio-temporal gaps by “thinking/guessing” make
it even harder to tackle. Different opposing observations undermine our understanding
of ischemic stroke evolution, especially at the acute stage: viable tissue transiting into
dead tissue may be clear and intuitive, however, “visibly” dead tissue restoring to full
recovery is still unclear.
In this thesis, we search for potential answers to these raised questions from a
novel dynamic modelling perspective that would fill in some of the missing gaps in the
mechanisms of stroke evolution. We divided our thesis into five parts. In the first part,
we give a clinical and imaging background on stroke and state the objectives of this
thesis. In the second part, we summarize and review the literature in stroke and medical
imaging. We specifically spot gaps in the literature mainly related to medical image
analysis methods applied to acute-subacute ischemic stroke. We emphasize studies that
progressed the field and point out what major problems remain. Noticeably, we have
discovered that macroscopic (imaging-based) dynamic models that simulate how stroke
lesion evolves in space and time were completely overlooked: an untapped potential
that may alter and hone our understanding of stroke evolution. Progress in the dynamic
simulation of stroke was absent –if not inexistent.
In the third part, we answer this new call and apply a novel current-based dynamic
model âpreviously applied to compare the evolution of facial characteristics between
Chimpanzees and Bonobos [Durrleman 2010] – to ischemic stroke. This sets a robust
numerical framework and provides us with mathematical tools to fill in the missing
gaps between MR acquisition time points and estimate a four-dimensional evolution
scenario of perfusion and diffusion lesion surfaces. We then detect two characteristics
of patterns of abnormal tissue boundary change: spatial, describing the direction of
change –outward as tissue boundary expands or inward as it contracts–; and kinetic,
describing the intensity (norm) of the speed of contracting and expanding ischemic
regions. Then, we compare intra- and inter-patients estimated patterns of change in
diffusion and perfusion data. Nevertheless, topology change limits this approach: it
cannot handle shapes with different parts that vary in number over time (eg: fragmented
stroke lesions, especially in diffusion scans, which are common).
In the fourth part, we suggest a new mathematical dynamic model to increase
rigor in the imaging-based dynamic modeling field as a whole by overcoming the
topology-change hurdle. Metamorphosis. It morphs one source image into a target one
[Trouvé 2005]. In this manuscript, we extend it into dealing with more than two time-indexed
images. We propose a novel extension of image-to-image metamorphosis into
longitudinal metamorphosis for estimating an evolution scenario of both scattered and
solitary ischemic lesions visible on serial MR. It is worth noting that the spatio-temporal
metamorphosis we developed is a generic model that can be used to examine intensity
and shape changes in time-series imaging and study different brain diseases or disorders.
In the fifth part, we discuss our main findings and investigate future directions to
explore to sharpen our understanding of ischemia evolution patterns
Measuring Prefrontal Hemodynamic Responses Using Functional Near-Infrared Spectroscopy During Mobility for a Child With Motor Impairment
No full textAbstract
Date Presented 3/31/2017
This study used functional near-infrared spectroscopy (fNIRS) to identify changes in cognitive workload in a child with motor impairment during experiences with robot-assisted mobility. The study provides preliminary support for using fNIRS to measure cognitive workload in novel motor tasks.
Primary Author and Speaker: Kelly Cusick
Additional Authors and Speakers: Alexandra DiStasi, Stephanie Holowinski, Olivia Fitzpatrick
Contributing Authors: Megan Davis, Melody H. Wallace, Sharon A. Stansfield, Carole Dennis, Hélène M. Larin, Nancy Rader, Judith Pena-Shaff</jats:p
Jac's River Adventure Teaching Guide in English
No full textJac's River Adventure Teaching Guide supports delivery and integration of Jac's River Adventure booklet into classrooms and other learning environments. The guide provides an overview of the booklet as well as suggested complementary activities based on experiences of teachers who integrated the booklet in their classrooms.
Jac's River Adventure Teaching Guide is presented in Januchowski-Hartley, S.R., Giannoulatou, I.D., Evans, J., Howells, S., Jones, D., and Humphreys, H. (in prep). Jac’s River Adventure: exploring a cross-curriculum approach to share knowledge and learn about rivers in classrooms
*Corresponding author: Stephanie Januchowski-Hartley, [email protected] or [email protected] </p
The effect of experimentally induced hypothyroidism on the isoflurane minimum alveolar concentration in dogs
No full textSCOP-1986
No full textCCC's student literary magazine containing poetry, short stories, essays, dramas, graphic short stories, and artwork created by Baltzer, David; Bates, H. K.; Braman, Bill; Carpenter, Christine; Carr, Sally; Costa, Phil; Donahue, Bob; Dorfeld, Wendi; Douglass, Joel; Eaton, Jennifer; Fasick, Tami; Gonzalez, Raymond; Hayes, Andrew; Hill, Timothy; Houston, Regina; Hoyt, Rick; Johnson, Stephanie; Lauer, Margaret; Lucus, Sharon; Lynn, Daniel; McNaney, Paul A.; Metal, Julie; Morgan, Elda Sarah; Ness, Lance; Price, Lee Ann; Quiggle, Scott; Recotta, Robert; Smith, Kathy; Smith, Laval; Twigg, Debbie; Webster, Nancy; Whiting, William; Young, William.Archived web conten
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