218,349 research outputs found
Essay: Frank B. Carpenter
No full textDocument, handwritten, artist Frank B. Carpenter and the Lincoln famil
Carpenter Organ
No full textRecto: [imprinted] Carpenter Organ, M. W. Vaughan, Gen'l Agt., 930 Main St., Dallas, Texas. Bufford. 949
Alastor (Alastor) venkataramani Kumar and Carpenter 2015
No full textAlastor (Alastor) venkataramani Kumar and Carpenter, 2015 Material examined. No specimens examined. Distribution. India: Telangana [Adilabad (Tarnam)] (Girish Kumar & Carpenter 2015).Published as part of Pannure, Arati & Carpenter, James M., 2016, Taxonomic studies on potter wasps (Hymenoptera: Vespidae: Eumeninae) of south India, pp. 1-50 in Zootaxa 4171 (1) on page 21, DOI: 10.11646/zootaxa.4171.1.1, http://zenodo.org/record/25809
Developments in the hydrogenation of challenging substrates utilising transition metal complexes
No full textThis thesis describes the developments of new protocols for the hydrogenation of challenging substrates. Three specific substrates were highlighted for study after an initial review of the literature; benzofurans, esters and bulky ketones.
Chapter 1 details a review of the hydrogenation of challenging unsaturated substrates, highlighting areas where development is still required.
Chapter 2 describes studies on the hydrogenation of 2,3-benzofuran. While a benzofuran hydrogenation catalysts was optimised, severe conditions were required to facilitate the reaction, and not found to be applicable for more elaborate substrates. We therefore considered an alternative process of enantioselective hydrogenation of benzofuranyl ketones followed by heterogeneous hydrogenation. A good process for transfer hydrogenation of a range of these hitherto unstudied substrates was developed along with greater understanding.
The hydrogenation of esters is another challenge in the catalytic reduction field, so was also selected for study, with the results described in Chapter 3. After screening a range of catalysts of types [RuCl₂ (diphosphine)(diamine)] and [RuCl₂ (PNX)(DMSO)], good catalysts were identified. Successful hydrogenation of a range of esters, under mild conditions was achieved using [RuCl₂ (1,3-bisdiphenylphosphinepropane)(2-aminomethylpyridine)] using high concentrations of base co-catalyst. [RuCl₂ ((2-(diphenylphosphanylbenzyl)ethane-1,2-diamine)(DMSO)] combined with 15-25 mol% of a basic co-catalyst have been shown to be active at near ambient conditions in the hydrogenation of aromatic esters.
Chapter 4 related to studies where the activity of Ru, Ir and Rh complexes of the same tridentate ligand were tested in the hydrogenation of ketones that would be regarded as sluggish substrates. Highly active and selective catalysts for the hydrogenation of bulky acetophenone derivatives were found using iridium complexes of PNX ligands (formed in situ). The highest selectivity was obtained with acetophenone substrates containing iso-propyl and cyclohexyl substituents, or medicinally important piperdinyl groups. In the best cases over 90% e.e. was observed with high conversions and with only 0.1 mol% of catalyst
Allorhynchium tuberculatum Girish Kumar & Carpenter 2016
No full text44) Allorhynchium tuberculatum Girish Kumar & Carpenter, 2016 Allorhynchium tuberculatum Girish Kumar & Carpenter, 2016: 30-33. Type data: Holotype male. Type locality: Ernakulam, Kerala, India. Distribution. India: Kerala. (Girish Kumar et al. 2016 a, Pannure et al. 2016).Published as part of Gawas, Sandesh M., Kumar, Girish, Pannure, Arati, Gupta, Ankita & Carpenter, James M., 2020, An annotated distributional checklist of Vespidae (Hymenoptera: Vespoidea) of India, pp. 1-87 in Zootaxa 4784 (1) on page 16, DOI: 10.11646/zootaxa.4784.1.1, http://zenodo.org/record/386231
Discoelius vasukii Pannure & Carpenter 2017
No full text187) Discoelius vasukii Pannure & Carpenter, 2017 Discoelius vasukii Pannure & Carpenter, 2017: 583-586. Type data: Holotype female, IMUASB. Type locality: Valparai, Coimbatore, Tamil Nadu, India. Distribution. India: Kerala, Tamil Nadu. (Pannure et al. 2018, Girish Kumar et al. 2018a).Published as part of Gawas, Sandesh M., Kumar, Girish, Pannure, Arati, Gupta, Ankita & Carpenter, James M., 2020, An annotated distributional checklist of Vespidae (Hymenoptera: Vespoidea) of India, pp. 1-87 in Zootaxa 4784 (1) on page 44, DOI: 10.11646/zootaxa.4784.1.1, http://zenodo.org/record/386231
Parancistrocerus turensis Girish Kumar & Carpenter 2016
No full text142) Parancistrocerus turensis Girish Kumar & Carpenter, 2016 Parancistrocerus turensis Girish Kumar & Carpenter, 2016e:150. Type data: Holotype female, ZSIK. Type locality: Garo Hills, Tura, Meghalaya, India. Distribution. India: Meghalaya. (Girish Kumar et al. 2016e).Published as part of Gawas, Sandesh M., Kumar, Girish, Pannure, Arati, Gupta, Ankita & Carpenter, James M., 2020, An annotated distributional checklist of Vespidae (Hymenoptera: Vespoidea) of India, pp. 1-87 in Zootaxa 4784 (1) on page 35, DOI: 10.11646/zootaxa.4784.1.1, http://zenodo.org/record/386231
Epsilon manasicum Girish Kumar & Carpenter 2014
No full text99) Epsilon manasicum Girish Kumar & Carpenter, 2014 Epsilon manasicum Girish Kumar & Carpenter, 2014a: 5382. Type data: Holotype female, NZC. Type locality: Doimari, Manas National Park, Assam, India. Distribution. India: Assam, West Bengal. (Girish Kumar et al. 2014a).Published as part of Gawas, Sandesh M., Kumar, Girish, Pannure, Arati, Gupta, Ankita & Carpenter, James M., 2020, An annotated distributional checklist of Vespidae (Hymenoptera: Vespoidea) of India, pp. 1-87 in Zootaxa 4784 (1) on page 28, DOI: 10.11646/zootaxa.4784.1.1, http://zenodo.org/record/386231
Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization
Full text linkCarpenter syndrome is an autosomal-recessive multiple-congenital-malformation disorder characterized by multisuture craniosynostosis and polysyndactyly of the hands and feet; many other clinical features occur, and the most frequent include obesity, umbilical hernia, cryptorchidism, and congenital heart disease. Mutations of RAB23, encoding a small GTPase that regulates vesicular transport, are present in the majority of cases. Here, we describe a disorder caused by mutations in multiple epidermal-growth-factor-like-domains 8 (MEGF8), which exhibits substantial clinical overlap with Carpenter syndrome but is frequently associated with abnormal left-right patterning. We describe five affected individuals with similar dysmorphic facies, and three of them had either complete situs inversus, dextrocardia, or transposition of the great arteries; similar cardiac abnormalities were previously identified in a mouse mutant for the orthologous Megf8. The mutant alleles comprise one nonsense, three missense, and two splice-site mutations; we demonstrate in zebrafish that, in contrast to the wild-type protein, the proteins containing all three missense alterations provide only weak rescue of an early gastrulation phenotype induced by Megf8 knockdown. We conclude that mutations in MEGF8 cause a Carpenter syndrome subtype frequently associated with defective left-right patterning, probably through perturbation of signaling by hedgehog and nodal family members. We did not observe any subject with biallelic loss-of function mutations, suggesting that some residual MEGF8 function might be necessary for survival and might influence the phenotypes observed
Parancistrocerus jaferpaloti Girish Kumar & Carpenter 2016
No full text139) Parancistrocerus jaferpaloti Girish Kumar & Carpenter, 2016 Parancistrocerus jaferpaloti Girish Kumar & Carpenter, 2016e: 144. Type data: Holotype female, ZSIK. Type locality: Kozhikode, Kerala, India. Distribution. India: Kerala. (Girish Kumar et al. 2016e).Published as part of Gawas, Sandesh M., Kumar, Girish, Pannure, Arati, Gupta, Ankita & Carpenter, James M., 2020, An annotated distributional checklist of Vespidae (Hymenoptera: Vespoidea) of India, pp. 1-87 in Zootaxa 4784 (1) on page 35, DOI: 10.11646/zootaxa.4784.1.1, http://zenodo.org/record/386231
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