315 research outputs found
I piccoli padiglioni universitari progettati da Enrico Mandolesi a Cagliari
No full textBetween 1962 and 1964, Enrico Mandolesi designed three small pavilions for the University of Cagliari: the Great Models Pavilion for the Institute of Construction 377 377 Antonello Sanna, Giuseppina Monni, Emanuela Quaquero I PICCOLI PADIGLIONI UNIVERSITARI PROGETTATI DA ENRICO MANDOLESI A CAGLIARI Science, the Pavilion for the Institute of Hydraulics and the Institute of Genetics. In all cases, the “pictorial” dimension, placing on the same level the warm tones of the clinker and the neutral one of the reinforced concrete, shows the author’s firm belief that all the materials have the same relevance. This is a lesson that Mandolesi learns from Mario Ridolfi, precursor of the Italian realism that abolishes the hierarchy between structural elements and finishes and declares that the creative idea of architecture lies in the precision of details. In the Great Models Pavilion for the Institute of Construction Science he chose to create a new volume connected to preexisting buildings with a small building. The horizontal and vertical windows declare the non-structural nature of the envelope made of bricks. A cultured design approach that uses the paradigm of the Illinois Institute of Technology by Mies van de Rohe. The Institute of Genetics is a building composed of two small volumes articulated on two levels and hinged to an independent stairway with a square plan. In this case, on a formal level, the basic principle is the horizontality that Mandolesi pursues at every level of detail. The author applied a combined solution that includes solid brick walls and a steel structure that connects to the frames of the fixtures. Both cases represent an accurate narration of construction stories that uses the combination of different materials, classic elements and modern solutions, the rough surfaces of reinforced concrete and the smooth ones of brick strips
Myasthenia Gravis Treatment: From Old Drugs to Innovative Therapies with a Glimpse into the Future
No full text: Myasthenia gravis (MG) is a rare autoimmune disease that causes debilitating muscle weakness due to impaired neuromuscular transmission. Since most (about 80-90%) MG patients present autoantibodies against the acetylcholine receptor, standard medical therapy consists of symptomatic treatment with acetylcholinesterase inhibitors (e.g., pyridostigmine). In addition, considering the autoimmune basis of MG, standard therapy includes immunomodulating agents, such as corticosteroids, azathioprine, cyclosporine A, and cyclophosphamide. New strategies have been proposed for the treatment of MG and include complement blockade (i.e., eculizumab, ravulizumab, and zilucoplan) and neonatal Fc receptor antagonism (i.e., efgartigimod and rozanolixizumab). The aim of this review is to provide a detailed overview of the pre- and post-marketing evidence on the five pharmacological treatments most recently approved for the treatment of MG, by identifying both preclinical and clinical studies registered in clinicaltrials.gov. A description of the molecules currently under evaluation for the treatment of MG is also provided
“She Looks at Him with the Eyes of a Camera”: Female Visual Pleasures and the Polemic with Fetishism in Sally Potter’s Tango Lesson
No full textAuthor accepted manuscript version of an article published by Taylor & Francis in
Emanuela Guano (2004) She looks at him with the eyes of a camera: female visual pleasures and the polemic with fetishism in Sally Potter's Tango Lesson,Third Text, 18:5, 461-474, https://doi.org/10.1080/0952882042000251732.</p
Rome and its domes. Drawing, art and architecture
No full textAny analysis performed to gather data about architectural and urban heritage always begins with the observation of reality and the involvement established between the observer and the space around them. A spectator inevitably interprets what they see in a personal manner so as to give objects a speci c meaning. The ability to understand the data and the relationship between the parts and then assign it a value varies from person to person. That the mind can mediate the mental processes of perception-action- thought means that any direct analysis to understand a cultural asset is scienti cally extremely important. The critical process sparked by an on-site study exploits the concise graphic transcription of what is visible, including the graphics tool used to achieve that representation. This contribution will present a study performed by the author to gather data using the drawings of several domes in the historical centre of the city of Rome
Spinoza muore
No full textThe Author presents the philosopher's theories on life, death, suicide and eternity of mind. The Author argues that the mind truly achieves a personal identity only in the dimension of eternit
Towards a theory of interpretation: cartographical semiosis
No full textOver the last 10 years a new theory in the interpretation of cartography has takes shape. In her overview of the various interpretative approaches that have variously contributed to the present critical approach, the author identifies semiotics as one of the trails principally worth pursuing. A semiotic approach, namely a theory of cartographic interpretation, effectively shifts the emphasis from maps intended as mediation of territory to maps takes as agents, whereby actions to be carried out on territory are determined. This perspective may be defined as cartographic hermeneutics, since it undermines the very semiotic notion of map analysis: the study of maps relies not on autonomous semiosis but on a second level (or meta-semiotic) semiosis that is deeply rooted in and strictly related to first-level, territorial semiosis. In particular, the author focuses on two concepts: self-reference and iconization. The former, which constitutes the core of cartographic communication, is used to indicate the map’s ability to be accepted as such (by its mere existence) and to communicate independently of the intentions of the cartographer. The latter is the communicative process that results in circumstances and contingencies being communicated as truths (thanks to the self-referential nature of the map). Hence, as a model, the map does not represent territory but replaces it. Iconization means that direct knowledge of the world is sidelined, with the greater relevance being given to the knowledge generated by the map itself
“Del material de los sueños. Dibujos de arquitectura en la modernidad” di C. Montes Serrano
No full textL'autore del libro, Profesor Titular de Expresión Grafica Arquitectónica all'Escuelas de Arquitectura de Navarra y Valladolid, inizia dichiarando che, a suo parere, la storia del disegno architettonico del secolo scorso è ancora da scrivere. Chiarisce però subito che non ha la pretesa di colmare questo vuoto, bensì soltanto l'obiettivo di dare un contributo in tal senso.The author of the book, Profesor Titular de Expresión Grafica Arquitectónica in the Escuelas de Arquitectura de Navarra y Valladolid, begins by stating that in his opinion the history of twentieth-century architectural drawings has yet to be written. However, he immediately clarifies that he does not intend to remedy this situation but simply input his own contribution
Memory and Punishment. Historical Denialism, Free Speech and the Limits of Criminal Law
No full textThis book gives an overview of the introduction and evolution of the crime of denialism from synchronic as well as diachronic perspectives. The analysis includes different normative and judicial levels; it draws clear distinctions between potentially overlapping terms and combines a large interdisciplinary spectrum with a strict criminal law methodology.
The author does not investigate denialism as phenomenon, instead she concentrates rigorously on the criminalisation of denialist practices as a speech crime in Europe and discusses the implications of protecting historical institutional memory through criminal law. In doing so, the book goes beyond mere description; it also highlights problematic issues, i.e. those related to freedom of speech and the relation between criminal law and historical memory. Of great interest is the manner in which the criminalisation of denialism is related to major legal dynamics of the present time, namely the pivotal role of criminal law in the construction of a collective memory and the proliferation of ‘new’ speech crimes.
The book demonstrates the importance of a comparative study on denialism in a time of post-truth where the border between truth and false is hard to distinguish. It paves the way for a broader discussion about freedom of expression in a digital world, about fake news and post-truth scenarios, and ultimately about the need to protect ascertained and verified facts from the pollution of misinformation and the tools with which to do so. In the so-called post-truth era, it becomes paramount to define the principles of what can and cannot be told, and to draw a line between the two areas. Historic denialism and the related jurisdiction represent a key step in exploring this complex field
Cartographic Semiosis: Reality as Representation
No full textOver the last ten years, a new theory in the interpretation of cartography
has taken shape. In her overview of the various interpretative approaches
that have contributed to the present critical approach, the author notably
identifies semiotics. A semiotic approach, and the theory of cartographic
semiosis in particular, effectively shifts the emphasis from maps as a
mediation of territory to maps as agents, whereupon the actions to be
carried out in territory are determined. This perspective may be defined as cartographic hermeneutics, given that it undermines the very semiotic notion of map analysis
notion of map analysis
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