365 research outputs found
Cuanta más información, ¿mejor? : un estudio sobre el uso de las redes sociales no profesionales en los procesos de selección de personal
No full textFil: Lanusse, Lucía. Universidad de San Andrés. Departamento de Ciencias Sociales; Argentina
Challenges to optimize the activity and extend the lifespan of anthelmintic molecules in the presence of resistant helminth populations
No full textThe excellent broad spectrum efficacy, good toleratibility and low cost of the long time available drug compounds have accounted for the extended use chemically-based helminth control in farms animals.Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaInternational Conference on Global Challenges in Neglected Tropical DiseasesLeónEspañaUniversidad de LeónNational Center for Natural Products ResearchDrugs for Neglected Diseases Initiativ
Anthelmintic therapy in ruminant species: Understanding of the host-drug-parasite interaction
No full textInadequate use of anthelmitic drugs in livestock animals has led to therapeutic failures and to the dramatic widespread development of parasite resistance. Additional scientific knowledge on how to improve the use of available and novel molecules is required to avoid/delay resistance development. The time of parasite exposure to active drug concentrations determines the efficacy and/or persistence of activity for most of the anthelmintic drugs used in ruminants. The outcome from integrated pharmaco-parasitological research approaches addressed to interpret the host-drug-parasite relationship has greatly contributed to optimise drug activity. The integrated assessment of the drug disposition in the host, the mechanisms of drug influx/efflux in different target helminths, their biotransformation/detoxification capacities and the chemically-induced modulation of those transport/metabolism processes, has signified a relevant progress on the understanding of the pharmacology of anthelmintic drugs in ruminant species. Further pharmaco-parasitological interdisciplinary work, supported by the huge progress achieved on parasite genomics, will be essential to generate the basic scientific knowledge necessary to preserve existing and particularly, novel active ingredients as useful tools for parasite control in livestock animals. The basic and clinical pharmacology issues summarised in the current article contribute in that direction.Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
AQUÍ, EN ROCKLAND: UN REPORTAJE MULTIMEDIA SOBRE LA SALUD MENTAL EN LOS JÓVENES ESPAÑOLES
No full textTrabajo Fin de Grado leído en la Universidad Rey Juan Carlos en el curso académico 2023/2024. Directores/as: María Eugenia Lozano LópezUn reportaje multimedia que pretende informar , dar voz y reivindicar a las víctimas más vulnerables de la actual crisis de salud mental que nos asola internacionalmente: los jóvenes.
En este proyecto no solo se recopiló información de numerosos estudios y asociaciones sino que también se entrevistaron a varios pacientes y profesionales en la materia para dotarle de un toque más personal, sin dejar de lado el rigor científico que debe caracterizar a este tipo de trabajos
Anticestodal and antitrematodal drugs
No full textANTICESTODAL DRUGS Introduction Bunamidine Niclosamide Praziquantel Epsiprantel ANTITREMATODAL DRUGS Introduction. Fasciolosis. Nitrophenolic compounds: nitroxynil, disophenol, niclofolan Salicylanilides: closantel, rafoxanide, oxiclozanide Benzenesulphonamides: clorsulon Benzimidazoles: albendazole, netobimin, triclabendazole Phenoxyalkanes: diamphenethideFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentin
EL TAROT, LAS CARAS DEL DESTINO:ENSAYO FOTOGRÁFICO
No full textTrabajo Fin de Grado leído en la Universidad Rey Juan Carlos en el curso académico 2022/2023. Directores/as: Ernesto José Taborda HernándezDurante años, la cartomancia y el ocultismo han ido ganando
aficionados. La práctica del tarot se ha extendido de tal manera que, el
diseño de nuevas barajas se aleja del mazo común marsellés.
Actualmente, se trabaja en naipes temáticos, relacionados con el cine,
la literatura, la historia o la mitología. Este proyecto fotográfico tiene
su inspiración en los naipes, más concretamente de algunos de los
arcanos mayores, alejándose de una representación literal y visual de
cada carta, y centrándose en lo metafórico, a través de la simbología y
el significado que se les ha otorgado en la adivinación. Se buscará un
estilo místico y misterioso, relacionado con la magia que envuelve a la
cartomancia. Se ha estudiado también el lenguaje oculto de las flores,
cuya simbología, al igual que en el tarot, ha pervivido desde épocas
más antiguas, y en diversas culturas, teniendo así, un gran peso como
elemento de cohesión en la maquetación de cada naipe
Fenbendazole and triclabendazole effects on CYP1A1/1A2 and FMO1/3 mRNAs in cattle liver slices: preliminary results
No full textBackground. Fenbendazole (FBZ) and triclabendazole (TCBZ) are benzimidazole drugs (BZDs) widely used in veterinary practice as anthelmintics. Members of cytochrome P450 (CYP) and flavin monooxygenase (FMO) superfamilies of drug metabolizing enzymes are primarily responsible of their biotransformation1. The xenobiotic-dependent up-regulation of CYPs is well documented, while FMOs are generally considered not inducible2. In the present study, the effect of FBZ and TCBZ (alone or in combination) on CYP1A1/2 and FMO1/3 mRNA levels were measured on precision-cut bovine liver slices (bLS).
Methods. Precision-cut bLS from 6 male cattle were obtained according to Maté et al3. Following the fine-tuning of an absolute quantification protocol for target genes4, bLS were incubated for 0, 6 and 12 h with FBZ and TCBZ (50 μM), alone or in combination. β-naphthoflavone (βNF, 25 μM) was used as positive control to confirm gene induction. Target gene mRNA levels were measured by qPCR. The TATA Box binding protein and ribosomal protein lateral stalk subunit P0/β-actin were used as internal control genes to normalize FBZ/TCBZ and βNF data, respectively.
Results. At T0, CYP1A2 mRNA levels were 25-fold higher than CYP1A1; however, FMO1 and 3 were equally represented. βNF up-regulated CYP1A1 (P<0.05; 4-fold vs control) after 6 h of incubation, while increasing amounts (P<0.05) of CYP1A2, FMO1/3 mRNAs were noticed after 12 h (4-, 2.5- and 3.5-fold vs control, respectively). Concerning BZDs, FBZ increased CYP1A1/2 mRNAs (P<0.05) after 12 h of incubation, whereas TCBZ up-regulated only FMO3 (P<0.05) and after 6 h. No transcriptional effect was ever noticed following bLS exposure to BZDs combination.
Conclusion. Likewise to humans, bLS appear to be a reliable model to study CYP1A induction by NF and other potential aryl hydrocarbon receptor agonists. Meanwhile, for the first time we proved cattle FMO1-3 up-regulation by NF. About BZDs, FBZ and TCBZ were shown to affect CYP1A1/2 and FMO3 gene expression. Confirmatory studies on CYP1A and FMOs catalytic activities are actually underway
Veterinary Drug Residues in Meat-Related Edible Tissues
No full textVeterinary drugs are chemicals used to control diseases in animals. If good veterinary practices are followed, these drugs are very useful and make it possible to obtain excellent and abundant food production. In order to protect the consumer’s health, foodstuffs of animal origin must not contain drug residues that might constitute a health hazard. A series of food-related issues together with food-related fear (additives, residues, the genetically modified products, animal cloning) have drawn consumers’ and authorities’ attention to food safety. New principles such as risk analysis, traceability, and an integrated food chain from farm to table have been introduced, with hormone and veterinary drug residues in food, in particular meat, being a highly topical case. The safety of residues is evaluated by setting a no observed (adverse) effect level (NOAEL) and using uncertainty factors to determine an acceptable daily intake (ADI) on which subsequently maximum residue limits (MRLs) are established. Veterinary drugs must be registered in government agency, which are also in charge of setting drug MRLs in food. In order to know trends in use of veterinary drugs, official drug residue monitoring programs are carried out by several countries. Different factors related to the drug (type of formulation, site and route of administration, dose, use of combinations, and time after administration) or animal (breed, animal age, sex, and body condition) can have profound effects on the pharmacokinetics and drug residue levels in meat and edible tissues. After animal drug administration, tissues with the highest drug residues are usually liver, kidney, and fat, with residues in meat being very low. However, as a consequence of several misuses (extralabel use, noncompliance with withdrawal periods) much higher residue levels may appear in meat and edible tissues and produce adverse effects on people consuming these foodstuffs and/or have an economic impact.Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentin
Specific Veterinary Drug Residues of Concern in Meat Production
No full textA broad variety of veterinary drugs are used in livestock and they could therefore appear as residues in meat and edible tissues for human consumption. Antibiotics to treat bacterial infections, anthelmintics to control parasites, and β-agonists as growth-promoting agents have been reported as some of the most commonly used drugs. The amount, frequency, and risk associated with their use and the impact on human health have been the criteria to consider them of special concern in livestock meat production. The main groups of drugs used in “mass medication,” antibacterial (β-lactam, quinolones/fluoroquinolones, aminoglycosides/aminocyclitols, sulfonamides, tetracyclines, macrolides) and antiparasitic/anthelmintic drugs (benzimidazoles, avermectins and milbemycins, levamisol, AADs) are described. The extensive therapeutic, metaphylactic, prophylactic or growth promoter uses of antibiotics have supported the intensification of modern food-animal production. However, a major concern is that inappropriate uses in livestock can generate antibiotic resistance in nonpathogenic bacteria, whose genes are transferred to pathogenic bacteria, resulting in antibiotic-resistant infections for humans. Anthelmintics are drugs used to treat flat (trematodes and cestodes) and round (nematodes) worm infections, a serious and common problem in livestock to such an extent that these drugs are traditionally used in farming. The β-agonist group, used for a long time in the treatment of respiratory diseases and as tocolytics, has been considered regarding its activity as growth promoters in meat production species, phenethanolamine derivatives (ractopamine and zilpaterol) being the most widely used drugs. However, opinions about their effect on meat are controversial: some authors agree on the use of β-agonists to achieve better utilization of food and sensory characteristics of meat, while others disagree because of the adverse consequences of using these substances.Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentin
Comparative assessment of different ivermectin and doramectin formulations for mange control in grazing steers
No full textPsoroptic mange causes relevant losses of productivity in cattle. Macrocyclic lactones are one of the main pharmacological tools recommended for controlling it. The aim of the current work was to compare the relationship between the pharmacokinetic behavior and the effectiveness of both ivermectin (IVM) and doramectin (DRM) following their administration as either the traditional (1 %) or long-acting (3.15–3.5 %) injectable formulations to cattle naturally infected with Psoroptes ovis. The overall work involved three trials (1, 2 and 3) carried out on commercial beef cattle farms (grazing systems). In Trial 1, 20 grazing steers with active mange infection were allocated into 2 groups (n = 10) and treated subcutaneously (SC) with either IVM (1 %) or DRM (1%) at 0.2 mg/kg. In Trial 2, 16 grazing steers with active mange divided in 2 groups (n = 8) were treated SC with either IVM 1 % (0.2 mg/kg) or IVM 3.15 % long-acting (0.63 mg/kg). In Trial 3, 2 groups of mange infected steers (n = 8) were treated SC with either IVM 3.15 % (0.63 mg/kg) or DRM 3.5 % (0.7 mg/kg). Blood samples were collected of each experimental group and the drug systemic availability was estimated by measuring of IVM/DRM concentrations by HPLC. Skin scraping samples were collected from each animal and mites were counted at 14, 21 and 28 days post-treatment. In Trial 1, the mite density score on day 14 was significantly lower for DRM (0.60) compared to IVM (1.80) (P = 0.019). Based on the number of animals clinically cured (negative to the presence of mites), the efficacy of DRM was higher (80 %) than that obtained for IVM (10 %) (P < 0.05). DRM systemic exposure measured as AUC was 1.37-fold higher compared to IVM. In Trial 2, even though IVM exposure was significantly greater after the long-acting (3.15 %) compared to the traditional formulation (1 %), none of the treatments significantly reduced the mite density score, with a percentage of animals cured between 0 % and 37.5 % after both IVM treatments. In Trial 3, the 100 % of cured animals were achieved at day 21 (IVM 3.15 %) and at day 28 (DRM 3.5 %) post-treatment. In conclusion, DRM treatment could offer some therapeutic advantages in field situations where IVM fails to control mange. Depending on the level of susceptibility of the mite population, long-acting pharmaceutical formulations can be useful to control Psoroptic mange in cattle. The use of macrocyclic lactones for mange control in cattle should be based on appropriate diagnosis on each individual farm.EEA RafaelaFil: Canton, Candela. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; ArgentinaFil: Canton, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Muchiut, Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina.Fil: Dominguez, Maria Paula. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; ArgentinaFil: Lanusse, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Alvarez, Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; ArgentinaFil: Alvarez, Luis . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Lifschitz, Adrián. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; ArgentinaFil: Lifschitz, Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentin
- …
