111,990 research outputs found
Nazioni Unite - Il Protocollo aggiuntivo alla Convenzione contro la tortura e gli altri trattamenti crudeli, inumani e degradanti (di V. Fiorese, in: I Diritti dell'Uomo, 2003 n.1)
No full textauthor-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Enhanced tissue factor expression by blood eosinophils from patients with hypereosinophilia: a possible link with thrombosis.
No full textThrombotic risk is increased in eosinophil-mediated disorders, and several hypotheses have been proposed to link eosinophilia and thrombosis. In particular, eosinophils have been described as source of tissue factor (TF), the main initiator of blood coagulation; however, this aspect is still controversial. This study was aimed to evaluate whether TF expression varies in eosinophils isolated from normal subjects and patients with different hypereosinophilic conditions. Eosinophils were immunologically purified from peripheral blood samples of 9 patients with different hypereosinophilic conditions and 9 normal subjects. Western blot analysis and real-time polymerase chain reaction (RT-PCR) were performed to test eosinophil TF expression. For comparison, TF expression was evaluated in monocytes from blood donors and in human endothelial (ECV304) and fibroblast (IMR90) cell lines. Western blot analysis revealed a major band of 47,000 corresponding to native TF in homogenates of purified eosinophils with a higher intensity in the 9 patients than in the 9 controls (p<0.0001). According to RT-PCR cycle threshold (Ct), TF gene expression was higher in eosinophils from patients than in those from controls, median (range) 35.10 (19.45-36.50) vs 37.17 (35.33-37.87) (p = 0.002), and was particularly abundant in one patient with idiopathic hypereosinophilic syndrome and ischemic heart attacks (Ct: 19.45). TF gene expression was moderate in monocytes, Ct: 31.32 (29.82-33.49) and abundant in endothelial cells, Ct: 28.70 (27.79-29.57) and fibroblasts, Ct: 22.77 (19.22-25.05). Our results indicate that human blood eosinophils contain variable amounts of TF. The higher TF expression in patients with hypereosinophilic disorders may contribute to increase the thrombotic risk
Pseudoscopas carbonelli Matiotti
No full textPseudoscopas carbonelli Matiotti da Costa, n. sp. (Figs 1-4) Etymology. The specific epithet refers to a tribute to the great orthopterologist Carlos Salvador Carbonell, in memorial who dedicated his life to working brilliantly with Neotropical grasshopper taxonomy. Diagnosis. Close to P. nigrigena, but differentiated by coloration of the body, epiproct without protuberances in median region and absence of sclerotization in edge of the cerci. Combination of the following characteristics: (i) Epiproct triangular with deep median sulci in apical portion with five conspicuous protuberances in the median region and edge of the apical region sclerotized and curved; (ii) furculae divided in two small lobes; (iii) pallium lobes small; (iv) male cerci triangular, wide and robust at the base, and with sclerotized acute apex, curving inward; (v) hind edge of the female subgenital plate forming two large lobes on both sides; (vi) plan bridge with median reentrancy; (vii) ancorae larger in size than of the anterior projections; (viii) lophi prominent and sclerotized. Body morphology and coloration Description. Male Holotype (Figs. 1–3). Body medium in size (18 mm length), moderately robust and deeply pubescent, especially the femorae and tibiae. Braquipterous. Head. Front subvertical, slightly oblique (Fig. 3A) and conspicuously larger than usual (Fig. 3B). Antennae filiform, with 18 antennomeres surpassing the posterior margin of pronotum. Eyes globular, laterally salient and not exceeding the vertex. Interocular space narrow (Fig. 3A). Face little retreating. Frontal costa plan (Fig.3A). Occiput smooth (Fig. 3B). Fastigium of the vertex subtriangular, shorter, with apex of vertex slightly rounded (Fig.2A). Thorax. Pronotum with median carina slightly marked, and lateral absent (Fig. 2A); metazona shorter than prozona; pronotum disc crossed by three transverse sulci; pronotum lateral edges parallel, slightly expanding in the metazona; anterior margin straight and the posterior with slight median emargination (Fig. 2A). Prosternal process spiniform. Mesosternal lobes rounded. Tegmen short, lobuliform, reaching to the second abdominal segment (Fig. 2A). Legs. Hind femur slender, the upper keel smooth, the end of lower knee lobes rounded. Hind tibiae pubescent with 7 outer and 8 inner dorsal spines; absence of hind femur’s terminal spinous projection on the dorsal genicular lobes (Fig. 2A). Abdomen. Tympanum large. Abdomen thickened in distal region. Epiproct triangular, longer than wider with deep median sulci in apical portion and five conspicuous protuberances in the median region; edge of the apical region sclerotized and curved apex rounded; furculae divided in two small lobes (Fig. 3C). Pallium with small and salient lobes (Fig. 3C). Cerci triangular, robust, conic, pubescent, strongly curved, exceeding the epiproct apex; acute and sclerotized apex (Fig. 3D). Subgenital plate cupuliform, short, curved up, apex rounded and pubescent (Fig. 3D). Phallic complex. Cingulum with long apodemes, arch developed; gonophore with a rectangular ventral projection (Fig. 4A); aedeagus long with upper and lower valves of the same size and median longitudinal sulci in the apical valves; sclerites of aedeagus covered by the wide and highly lobulated ectophallic sheath (Fig. 4A). Epiphallus with plan bridge and median reentrancy; ancorae larger in size than of the anterior projections; lophi prominent and sclerotized; without internal conical protuberance (Fig. 4B). Body brown light color (Figs 1A, 2A, 3 A-B). Head mostly yellow color with a black pair of retro-ocular bands that take part of the genae, and continue in the dorsal half of the pronotum lateral lobes, tegmina, pleural and sides of the abdomen. Scape, pedicel, and antennal flagellum brown color. Fastigium of the vertex with five brown spots (Fig. 2A). Occiput marked with brown spots. Face, clypeus, and genae yellowish color; mandible and labrum black color; labial and maxillary palpi yellowish color with black tip (Fig. 3B). Light brown antennae. Pronotum dorsally with several punctures and brown spots (Fig. 2A). Lateral lobes of the pronotum with a yellow ivory band on the lower abdomen (Fig. 3A). Tegmen with veins light brown, a narrow ivory band surrounding the dorsal portion of the wing (Fig. 2A). Genicular lunules black. Legs I and II green, with pretarsus tip, arolium and claws brown color; femur III yellow-green, with genicular lobe black; tibiae III light-blue, with tarsomeres light green, and tarsal claws and arolium brown. Lateral sclerites of the abdomen yellowed from the second segment. Dorsal and ventral abdominal segments and pallium brown. Female. Larger in size to male, robust (body length 21mm) (Fig. 1B, 2B). Same color as male, but the head more yellowish (Fig. 2B); fastigium more prominent and wider than in males and with brown color spots; eyes more prominent. Interocular space wider. Pronotum dorsally light green, with several punctures and brown punctuation spots. Lateral lobes of the pronotum with a reddish, yellow-green and ivory bands, from upper to lower portion (Fig. 1B). Abdomen sides with a black spot in between segments 3-6. Ovipositor valves short in lateral view and serrulated margins absent (Fig. 3E); dorsal valve of the ovipositor robust and apical tooth of the external ventral valve of ovipositor little prominent. Hind edge of the female subgenital plate forming two large lobes on both sides and without sclerotization (Fig. 3F). Legs I and II less robust than in males. Cerci short, conical, not reaching the epiproct tip (Fig.3E). Epiproct subtriangular with median sulcus well marked, interrupted transversely in the median region. Habitat and Habits. Individuals of P. carbonelli n. sp. were collected mainly during the day, being active on bushes and grasses of the edge of the forest in more open places and with lower canopy cover (Fig.6), usually between 11am to 5pm. The records of the genus Pseudoscopas are between the Pampean and Parana provinces, but P. carbonelli is found only in the southeast of the Parana province. (Morrone 2001; 2006). Measurements (mm): Males (n=7): BL= 18.1 (17.4–18.1); PL = 0.3 (0.2–0.3); FL3 = 0.8 (0.7–0.8); TL = 0.3 (0.2–0.3). Females (n = 8): BL = 21.1 (19.2–21.1); PL = 0.5 (0.4–0.5); FL3 = 0.9 (0.8–0.9); TL = 0.4 (0.3 – 0.4). Type material. Holotype ♂. BRAZIL: Rio Grande do Sul, municipality of São Francisco de Paula, (29°24’44.16”S 50°12’30.44”W), 27-30.i.2020, Zefa, E.; Acosta R.C. & Tim, V., 7♂ and 8♀ (MCTP). Holotype condition: genitalia were extracted and maintained in holotype’s tube. Chromosomes (Figs. 5 A-D). Diploid chromosome number of 2n=23, X0 ♂ /24, XX ♀; all chromosomes acrocentrics, grouped in two chromosome pairs large (L 1 –L 2), two pairs medium large (ML 3 – ML 4), five medium (M 5 –M 9), and two small (S 10 –S 11) (Fig. 5A); the X chromosome belongs to the ML group, and the megameric to the M group, both showing positive heteropiknosis until diplotene phase (Fig. 5C, D). Metaphase I chiasmata position: L 1, proximal and intersticial; L 2, proximal and intersticial; ML 3, proximal and subterminal; ML 4, subterminal; M 5, terminal; M 6, terminal; M 7, terminal; M 8, intersticial; M 9, intersticial; S 10, terminal; S 11, terminal (Fig. 5B). The size relationship between chromosomes can be better seen in (Fig. 5E), which includes a metaphase II. Genus distribution. Brazil (Paraná; Santa Catarina; Rio Grande do Sul); Argentina (Misiones, Concepción); Paraguay (Sapucay, Caaguazú); Uruguay (Caraguatay, Cuchilla Negra, Tacuarembó) (Cigliano et al. 2021; Ronderos 1987; Mesa et al. 1982; Monné 2018) (Table 1, Fig. 7).Published as part of Costa, Maria Kátia Matiotti Da, Acosta, Riuler Corrêa, Timm, Vítor Falchi, Demari, Christian Peter, Carvalho, Gervásio Silva & Zefa, Edison, 2021, Pseudoscopas carbonelli n. sp. (Orthoptera: Acrididae: Melanoplinae) from southern Brazil, including chromosome complement, pp. 127-140 in Zootaxa 4975 (1) on pages 128-133, DOI: 10.11646/zootaxa.4975.1.4, http://zenodo.org/record/480527
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Esteri alchilsolforici con attività antiproliferativa da diverse specie di ascidie del Mediterraneo
No full textStudio chimico condotto su campioni di Ascidia mentula, Microcosmus vulgaris, Halocynthia papillosa e Sidnyum turbinatu
Co‐occurrence of IgE and IgG autoantibodies in patients with chronic spontaneous urticaria
No full textChronic spontaneous urticaria (CSU) pathogenesis shows a complex and still unclear interplay between immunoglobulin (Ig)G- and IgE-mediated autoimmunity, leading to mast cell and basophil degranulation and wheal formation. The objective of this study was to evaluate at the same time IgE- and IgG-reactivity to well recognized and recently reported autoantigens in CSU patients, and to assess the effects of such reactivity on response to the anti-IgE monoclonal antibody omalizumab. Twenty CSU patients underwent omalizumab treatment. Urticaria activity score 7 (UAS7) was recorded at baseline and at different drug administration time-points for categorizing early-, late- or non-responders. At baseline, sera from the 20 patients and from 20 controls were tested for IgE and IgG autoantibodies to high- and low-affinity IgE receptors (FcεRI and FcεRII), tissue factor (TF) and thyroglobulin (TG) by immunoenzymatic methods. Antibody levels were compared with those of controls and analysed according to response. Eighteen patients were omalizumab responders (11 early and seven late), while two were non-responders. More than 50% of patients had contemporary IgE and IgG to at least to one of the four different autoantigens. Late responders showed higher levels of both anti-TF IgE and IgG than early responders (P = 0·011 and P = 0·035, respectively). Twenty-five per cent of patients had levels of anti-FcεRI IgE, exceeding the upper normal limit, suggesting that it could be a novel auto-allergen in CSU. In CSU, there is an autoimmune milieu characterized by the co-existence of IgE and IgG autoantibodies to the same antigen/allergen, particularly in late responders to omalizumab, possibly explaining the slower response
Therapeutic Options in Hereditary Optic Neuropathies
No full textOptions for the effective treatment of hereditary optic neuropathies have been a long time coming. The successful launch of the antioxidant idebenone for Leber’s Hereditary Optic Neuropathy (LHON), followed by its introduction into clinical practice across Europe, was an important step forward. Nevertheless, other options, especially for a variety of mitochondrial optic neuropathies such as dominant optic atrophy (DOA), are needed, and a number of pharmaceutical agents, acting on different molecular pathways, are currently under development. These include gene therapy, which has reached Phase III development for LHON, but is expected to be developed also for DOA, whilst most of the other agents (other antioxidants, anti-apoptotic drugs, activators of mitobiogenesis, etc.) are almost all at Phase II or at preclinical stage of research. Here, we review proposed target mechanisms, preclinical evidence, available clinical trials with primary endpoints and results, of a wide range of tested molecules, to give an overview of the field, also providing the landscape of future scenarios, including gene therapy, gene editing, and reproductive options to prevent transmission of mitochondrial DNA mutations
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