96 research outputs found
Maria Concetta Carbone (in Piacente)
No full textVideo interview with Maria Concetta Carbone (in Piacente) as part of the Italian Cinema Audiences projec
Compliance mechanisms under selected multilateral environmental agreements, (Co-author Ulrich Beyerlin)
No full textThe Figure of the Limit: Metalepsis
No full textIn 1972, Gérard Genette introduced in narratology the figure of metalepsis, that is «any intrusion by the extradiegetic narrator or narratee into the diegetic universe (or by diegetic characters into a metadiegetic universe, etc.), or the inverse». In other words, metalepsis is a transgression of narrative levels, a perturbation of hierarchy that raises the question of the porosity of boundaries between diegetic and metadiegetic, author and reader, fact and fiction.
In my presentation, I will show how this phenomenon is ubiquitous nowadays, and how it is settled both in highbrow and lowbrow cultural representations across various media.
Furthermore, I wish I can discuss the role of metalepsis in poetics: in my opinion, it is possible to relate this device with the history of the novel. In XVIII and XIX centuries authorial narrators made extensive use of rhetoric metalepsis for humoristic purposes (such as playing with the story-time and the discourse-time) or to exhibit their authority (through the manipulation of different threads of the narration). With Naturalism and Modernism metalepsis disappeared, according to the poetic of impersonality: authors stopped being intrusive and eclipsed behind their characters. The golden era of the figure came in the temper of Postmodernism, where ontological metalepsis flourished and the public got used to author and reader literary entering the fiction or characters exiting from it and chitchatting with their creators
Andrea e gli argentieri Memingher in Sicilia
No full textAndrea Memingher è una tra le più enigmatiche figure di argentieri attivi a Palermo nella seconda metà del XVII secolo. Si può ritenere che la famiglia avesse origini nordiche e che, dopo un passaggio a Napoli, si stabilisse definitivamente a Palermo, inserendosi nella maestranza degli orafi e argentieri della città, probabilmente grazie ad un matrimonio con una figlia o una sorella o una vedova di un membro palermitano della maestranza. La presenza di Paolo Memingher nel capoluogo siciliano è attestata già nel 1660, due anni prima della data di inizio della sua attività, protrattasi fino al 1678. Il più importante esponente della famiglia fu Andrea, figlio di Paolo, il quale dovette la sua fama, al di là dell’abilità e dell’origine straniera, anche al suo status di padre gesuita. Il saggio studia la figura dell’artista, attivo dal 1670 al 1738, anno di morte, autore di un consistente corpus di opere giunto fino a noi, e dei congiunti che operarono nel medesimo contesto.Andrea Memingher is one of the most enigmatic figures of silversmiths active in Palermo in the second half of the seventeenth century. It can be assumed that the family had Nordic origins and that, after a passage to Naples, it settled permanently in Palermo, entering the mastery of the goldsmiths and silversmiths of the city, probably thanks to a marriage with a daughter or a sister or a widow of a Palermitan member of the mastery. The presence of Paolo Memingher in the Sicilian capital is attested as early as 1660, two years before the start of his activity, which lasted until 1678. The most important exponent of the family was Andrea, son of Paolo, who owed his fame, beyond the ability and foreign origin, even to his status as a Jesuit father. The essay studies the figure of the artist, active since 1670 to 1738, the year of his death, author of a substantial body of works that has come to us, and of the relatives who worked in the same context
La Vita S. Rosaliae di van Dyck nella Biblioteca della Fondazione Sicilia
No full textThe essay examines the Vita S. Rosaliae, a very rare collection of engravings taken from drawings by Antoon van Dyck, identified by the author and Maria Concetta Di Natale in the Sicily Foundation Library during preparatory research for the realisation of the exhibition 'The Ecstasies of Saint Rosalie - Antoon van Dyck, Pietro Novelli, Mattia Preti, Luca Giordano'
Insight into immune profile associated with vitiligo onset and anti-tumoral response in melanoma patients receiving anti-PD-1 immunotherapy
No full textIntroductionImmunotherapy with checkpoint inhibitors is an efficient treatment for metastatic melanoma. Development of vitiligo upon immunotherapy represents a specific immune-related adverse event (irAE) diagnosed in 15% of patients and associated with a positive clinical response. Therefore, a detailed characterization of immune cells during vitiligo onset in melanoma patients would give insight into the immune mechanisms mediating both the irAE and the anti-tumor response. MethodsTo better understand these aspects, we analyzed T cell subsets from peripheral blood of metastatic melanoma patients undergoing treatment with anti-programmed cell death protein (PD)-1 antibodies. To deeply characterize the antitumoral T cell response concomitant to vitiligo onset, we analyzed T cell content in skin biopsies collected from melanoma patients who developed vitiligo. Moreover, to further characterize T cells in vitiligo skin lesion of melanoma patients, we sequenced T cell receptor (TCR) of cells derived from biopsies of vitiligo and primary melanoma of the same patient.Results and discussionStratification of patients for developing or not developing vitiligo during anti-PD-1 therapy revealed an association between blood reduction of CD8-mucosal associated invariant T (MAIT), T helper (h) 17, natural killer (NK) CD56bright, and T regulatory (T-reg) cells and vitiligo onset. Consistently with the observed blood reduction of Th17 cells in melanoma patients developing vitiligo during immunotherapy, we found high amount of IL-17A expressing cells in the vitiligo skin biopsy, suggesting a possible migration of Th17 cells from the blood into the autoimmune lesion. Interestingly, except for a few cases, we found different TCR sequences between vitiligo and primary melanoma lesions. In contrast, shared TCR sequences were identified between vitiligo and metastatic tissues of the same patient. These data indicate that T cell response against normal melanocytes, which is involved in vitiligo onset, is not typically mediated by reactivation of specific T cell clones infiltrating primary melanoma but may be elicited by T cell clones targeting metastatic tissues. Altogether, our data indicate that anti-PD-1 therapy induces a de novo immune response, stimulated by the presence of metastatic cells, and composed of different T cell subtypes, which may trigger the development of vitiligo and the response against metastatic tumor
Experimental Investigations of Heat Transport Dynamics in a 1d Porous Medium Column
No full textAbstractThe present study involves the experimental investigation of heat transport due to the forced convective flow through a thermally isolated porous medium column.The experiments regard the observation of thermal breakthrough curves obtained through a hot flow injection in correspondence of two thermocouples positioned along a thermally isolated column of porous medium. The experiment has been carried out for three flow rates in order to investigate the critical issues regarding heat transport phenomena such as the relationship between the thermal dispersion with the flow velocity and the validity of the local thermal equilibrium assumption between the fluid and solid phase
Una scrittura della memoria. Le prose e i versi di Maria Attanasio
No full textMaria Attanasio (born in 1943) is an author of novels, stories, poetic collections, essays
and a photographic book illustrated by the shots of Giuseppe Leone, a refined iconotesto
whose subtitle reveals a clear Sciascian inspiration: Il divino e il meraviglioso. Feste religiose in Sicilia. The work of Attanasio, who published with Sellerio short novels such as Correva l’anno 1698 e nella città avvenne il fatto memorabile, Di Concetta e le sue donne and Il falsario di Caltagirone, is in some ways close to the formula of the Sciascian “cronachette”, which the writer has renamed “little chronicles” (“piccole cronache”). In her novels and in her verses the problems of memory, of archives, of documents and therefore of re-writing are central
A potential cause of asbestos-related granulomatosis due to adulterant contamination in a drug abuser
No full textDrug adulterants containing contaminants have been known to cause lung disease by inhalation or intravenous intake. Talcosis due to intravenous talc injection has been widely described in the literature, whereas the hypothesis of granulomatosis due to asbestos related to adulterated cocaine injection has not yet been explored. Herein, a case of pulmonary granulomatosis due to asbestos fibres related to cocaine injection in a young woman is described. Inorganic material in the lung was first individuated by light microscopy and last was identified using the SEM-EDX method. This case is unique since the occupational and passive inhalation of asbestos was excluded with absolute certainty
Lymphoepithelioma-like carcinoma of the ovary
No full textOnly one case of lymphoepithelioma-like carcinoma of the ovary has been reported so far. A new case is herein illustrated in a 69-year-old woman: an ovarian mass adherent to urinary bladder dome with peritoneal carcinomatosis. Histologically, undifferentiated carcinomatous areas were intermingled with abundant lymphoid tissue. Epstein-Barr virus has not been detected either in neoplastic or in lymphoid cells. © The Author(s) 2011
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