131,563 research outputs found
Caracciolo et al. Reply:
No full textWe reply to criticism by Patrascioiu and Seiler [hep-lat/9502019] of our results [Phys. Rev. Lett. 75, 1891 (1995), hep-lat/9411009] on asymptotic scaling in the two-dimensional -model, which were based on a finite-size-scaling extrapolation method
Scaling hypothesis for the Euclidean bipartite matching problem. II. Correlation functions
No full textWe analyze the random Euclidean bipartite matching problem on the hypertorus in d dimensions with quadratic cost and we derive the two-point correlation function for the optimal matching, using a proper ansatz introduced by Caracciolo [Phys. Rev. E 90, 012118 (2014)]PLEEE81539-375510.1103/PhysRevE.90.012118 to evaluate the average optimal matching cost. We consider both the grid-Poisson matching problem and the Poisson-Poisson matching problem. We also show that the correlation function is strictly related to the Green's function of the Laplace operator on the hypertorus
Embodied Cognition and the Grotesque in Calvino\u27s La giornata d\u27uno scrutatore and Sanguineti\u27s Capriccio italiano
No full textIn his article Embodied Cognition and the Grotesque in Calvino\u27s La giornata d\u27uno scrutatore and Sanguineti\u27s Capriccio italiano Marco Caracciolo analyzes the multiple dimensions of embodied experience and how they can be brought to bear on literary texts. Drawing on scholarship in cognitive science, he argues that the embodiment of people\u27s engagement with the world emerges from the interaction between the physical structure of the body and socio-cultural practices. Caracciolo shows how such nexus of biological make-up and culture can give rise to particularly complex meanings in the representation of grotesque bodies. In order to illustrate his postulates, Caracciolo analyzes Italo Calvino\u27s La giornata d\u27uno scrutatore (The Watcher) and Edoardo Sanguineti\u27s Capriccio italiano, wherein distorted bodies play an important role
Nanoparticle-enabled blood tests for early detection of pancreatic ductal adenocarcinoma
No full textPancreatic ductal adenocarcinoma (PDAC) is often detected too late to allow adequate treatments with the result that patients are condemned to sufferings and early death. Most efforts have been therefore aimed at identifying sensitive PDAC biomarkers. Although biomarkers have numerous advantages, sample size, intra-individual variability, existence of several biases and confounding variables and cost of investigation make their clinical application challenging. In recent years, nanotechnology is providing new options for early cancer detection. Among recent discoveries, the concept is emerging that the protein corona, i.e. the layer of plasma proteins that surrounds nanomaterials in bodily fluids, is personalized. In particular, the protein corona of cancer patients is significantly different from that of healthy individuals. Herein, we review this concept with a particular focus on clinical relevance. We also discuss the recently developed nanoparticle-enabled blood (NEB) tests that demonstrated to be promising in discriminating PDAC patients from healthy volunteers by global change of the nanoparticle-protein corona. We conclude with a critical discussion of research perspectives aimed at further improving the prediction ability of the test
Looking Back, Moving Forward: Lipid Nanoparticles as a Promising Frontier in Gene Delivery
No full textLipid nanoparticles (LNPs) have shown remarkable success in delivering genetic materials like COVID-19 LNP vaccines, such as mRNA-1273/SpikeVax by Moderna and BNT162b2/Comirnaty by BioNTech/Pfizer, as well as siRNA for rare inherited diseases, such as Onpattro from Alnylam Pharmaceuticals. These LNPs are advantageous since they minimize side effects, target specific cells, and regulate payload delivery. There has been a surge of interest in these particles due to their success stories; however, we still do not know much about how they work. This perspective will recapitulate the evolution of lipid-based gene delivery, starting with Felgner's pioneering 1987 PNAS paper, which introduced the initial DNA-transfection method utilizing a synthetic cationic lipid. Our journey takes us to the early 2020s, a time when advancements in bionano interactions enabled us to create biomimetic lipoplexes characterized by a remarkable ability to evade capture by immune cells in vivo. Through this overview, we propose leveraging previous achievements to assist us in formulating improved research goals when optimizing LNPs for medical conditions such as infectious diseases, cancer, and heritable disorders
Noncommutative determinants, Cauchy-Binet formulae, and Capelli-type identities II. Grassmann and quantum oscillator algebra representation
No full textWe prove that, for X, Y, A and B matrices with entries in a non-commutative ring such that [Xij,Ykl]=−AilBkj, satisfying suitable commutation relations (in particular, X is a Manin matrix), the following identity holds: coldetXcoldetY=. Furthermore, if also Y is a Manin matrix, coldetXcoldetY=∫D(ψ,ψ†)exp[∑k≥01k+1(ψ†Aψ)k(ψ†XBkYψ)]. Notations: , are respectively the bra and the ket of the ground state, a† and a the creation and annihilation operators of a quantum harmonic oscillator, while ψ†i and ψi are Grassmann variables in a Berezin integral. These results should be seen as a generalization of the classical Cauchy-Binet formula, in which A and B are null matrices, and of the non-commutative generalization, the Capelli identity, in which A and B are identity matrices and [Xij,Xkl]=[Yij,Ykl]=0
I Premiati dell'Accademia. Catalogue de l'exposition, Accademia Nazionale di San Luca, Rome, décembre 1989-janvier 1990. Textes par G. Casale, D. Graf, R. Lattuada, O. Michel, A. Pampalone, S. Rudolph, M. Tomor, réunis par A. Cipriani. Rome, Quasar éditeur. 190 pages, 70 numéros, tous reproduits.
No full textCaracciolo Arizzoli Maria-Teresa. I Premiati dell'Accademia. Catalogue de l'exposition, Accademia Nazionale di San Luca, Rome, décembre 1989-janvier 1990. Textes par G. Casale, D. Graf, R. Lattuada, O. Michel, A. Pampalone, S. Rudolph, M. Tomor, réunis par A. Cipriani. Rome, Quasar éditeur. 190 pages, 70 numéros, tous reproduits.. In: Revue de l'Art, 1990, n°89. p. 85
Budyko’s Based Method for Annual Runoff Characterization across Different Climatic Areas: an Application to United States
No full textRunoff data knowledge is of fundamental importance for a wide range of hydrological, ecological, and socioeconomic applications. The reconstruction of annual runoff is a fundamental task for several activities related to water resources management, especially for ungauged basins. At catchment scales, the Budyko's framework provides an extremely useful and, in some cases, accurate estimation of the long-term partitioning of precipitation into evapotranspiration and runoff as a function of the prevailing climatic conditions. Recently the same long-term partitioning rules have been successfully used to describe water partitioning also at the annual scale and calculate the annual runoff distribution within a simple analytic framework in arid and semi-arid basins. One of the main advantages of the latter method is that only annual precipitation and potential evapotranspiration statistics, and the Fu's equation parameter omega are required to obtain the annual runoff probability distribution. The aim of this study is to test the limit and potentialities of the aforementioned method under different climatic conditions. To this aim, the model is applied to more than four hundred basins located in the United States. Catchments were grouped into five different samples, following the subdivision of the continental region in five homogeneous climatic zones according to Koppen-Geiger classification. The theoretical probability distribution of annual runoff at each basin has been compared with that derived from historical observations. The results confirm the capability of the tested technique to reproduce the empirical annual runoff distributions with similar and satisfactory performances across different areas, revealing a good option also in cases characterized by climate and hydrological conditions very different from those hypothesized during the original analytical model design, thus extending the geographical and conceptual limits of applicability of the framework
Il regno di Napoli diviso in dodici provincie : nel qvale brevemente si descrive la Città di Napoli, con le cose più principali ... nomi delle famiglie nobili, e d'altre città, terre, e castella, fortezze, e torri regi ...
No full textSign.: [cruz]\p4\s, A-P\p8\s, Q\p4\sErrores de paginación, P. 192-196 repetida la numeraciónGrabados xilográficos de escudos de ciudades napolitanas págs. [8], 5, 27, 53, 87, 100, 108, 122, 134 [i.e. 138], 153, 167, 175, 187 y 192 [i.e. 198
La salvaguardia del patrimonio aziendale tra controlli a distanza ed esercizio del diritto di proprietà
No full textNonostante la novella operata dall’art. 23, D. Lgs. 151/2015, permangono gli interrogativi che ruotano attorno all’applicazione dell’art. 4 St. Lav., specialmente nell’ottica del bilanciamento tra il diritto del datore di lavoro a salvaguardare il patrimonio aziendale dalle altrui aggressioni ed il diritto del lavoratore alla tutela della privacy. Scopo del presente contributo è delineare un’area ristretta all’interno della categoria dei “controlli difensivi” la cui sopravvivenza potrebbe trovare giustificazione in una reinterpretazione originaria, depurata dalle espansioni di matrice dottrinale e giurisprudenziale che si sono susseguite nello scorso decennio. Sarebbe possibile, dunque, individuare una serie di condotte – estranee all’attività lavorativa – in merito alle quali non si applicherebbe il combinato disposto dell’art. 4 St. Lav. e degli artt. 11, 13, 22, 23 D. Lgs. 196/2003, rendendo così possibile l’utilizzo dei dati raccolti al fine del licenziamento per giusta causa
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