152,818 research outputs found
Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review
No full textIntroduction. Cluster of Differentiation (CD) 93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp) is a transmembrane glycoprotein that can also be present in a soluble (sCD93) form. Recent studies have investigated the role of this protein in cardiovascular disease (CVD). The present systematic review aims to assess the associations between CD93 and cardiovascular (CV) risk factors and disease at both the proteomic and genomic levels. Methods. We conducted systematic searches in the PubMed, EMBASE, and Web of Science databases to identify all human studies since inception to February 2023 that investigated the role of CD93 in CV risk factors, CVD, and CV-associated outcomes. The data collection and analysis have been independently conducted by two reviewers. The search terms included: cardiovascular, heart failure, acute stroke, myocardial infarction, stroke, peripheral artery disease, cardiovascular death, MACE, hypertension, metabolic syndrome, hyperuricemia, diabetes, cd93, c1qr, C1qR1, complement protein 1 q subcomponent receptor. Results. A total of 182 references were identified, and 15 studies investigating the associations between CD93 protein levels or CD93 genetic polymorphisms and the development or prevalence of CV risk factors (i.e., hypertension, dyslipidemia, and obesity) and CVD (i.e., heart failure, coronary artery disease, and ischemic stroke) were included. Although promising, the quality and dimension of the analyzed studies do not allow for a definitive answer to the question of whether CD93 may hold diagnostic and prognostic value in CVD
Molecular Mechanisms of Proteinuria in Minimal Change Disease
No full textMinimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome in childhood and represents about 15% cases in adults. It is characterized by massive proteinuria, edema, hypoalbuminemia, and podocyte foot process effacement on electron microscopy. Clinical and experimental studies have shown an association between MCD and immune dysregulation. Given the lack of inflammatory changes or immunocomplex deposits in the kidney tissue, MCD has been traditionally thought to be mediated by an unknown circulating factor(s), probably released by T cells that directly target podocytes leading to podocyte ultrastructural changes and proteinuria. Not surprisingly, research efforts have focused on the role of T cells and podocytes in the disease process. Nevertheless, the pathogenesis of the disease remains a mystery. More recently, B cells have been postulated as an important player in the disease either by activating T cells or by releasing circulating autoantibodies against podocyte targets. There are also few reports of endothelial injury in MCD, but whether glomerular endothelial cells play a role in the disease remains unexplored. Genome-wide association studies are providing insights into the genetic susceptibility to develop the disease and found a link between MCD and certain human haplotype antigen variants. Altogether, these findings emphasize the complex interplay between the immune system, glomerular cells, and the genome, raising the possibility of distinct underlying triggers and/or mechanisms of proteinuria among patients with MCD. The heterogeneity of the disease and the lack of good animal models of MCD remain major obstacles in the understanding of MCD. In this study, we will review the most relevant candidate mediators and mechanisms of proteinuria involved in MCD and the current models of MCD-like injury
Acute Kidney Injury in Pediatric Diabetic Kidney Disease
No full textDiabetic kidney disease (DKD) is a common complication of type 1 and 2 diabetes and often presents during adolescence and young adulthood. Given the growing incidence of both type 1 and type 2 diabetes in children and adolescents, DKD represents a significant public health problem. Acute kidney injury (AKI) in youth with diabetes is strongly associated with risk of DKD development. This review will summarize the epidemiology and pathophysiology of AKI in children with diabetes, the relationship between AKI and DKD, and the potential therapeutic interventions. Finally, we will appraise the impact of the recent COVID-19 infection pandemic on AKI in children with diabetes
FUENTES, Heliodoro G.
No full textHeliodoro G. Fuentes se pone a las órdenes del Gral. PEC; pide permiso para gestionar la rendición de los rebeldes Onésimo, Doroteo y Severo Jiménez
Wedrówki Ahaswera : Poemat Józefa Chrzécijana barona Zedlitza, po raz pierwszy wydany polskim i zaopatrzony wstepnem slowem / przez G. Kohna ...
No full textWEDRÓWKI AHASWERA : POEMAT JÓZEFA CHRZÉCIJANA BARONA ZEDLITZA, PO RAZ PIERWSZY WYDANY POLSKIM I ZAOPATRZONY WSTEPNEM SLOWEM / PRZEZ G. KOHNA ...
Wedrówki Ahaswera : Poemat Józefa Chrzécijana barona Zedlitza, po raz pierwszy wydany polskim i zaopatrzony wstepnem slowem / przez G. Kohna ... (1)
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Presentación. Fuentes, 18, 2
No full textLa revista Fuentes comparte en este número monográfico las investigaciones y experiencias docentes de varios expertos en el ámbito de la enseñanza de segundas lenguas con el propósito de responder a una demanda social derivada del alto porcentaje de población inmigrante en España y, a la vez, de los programas de bilingüismo y plurilingüismo.
El monográfico se compone de ocho artículos, cuyo objeto de investigación cubre temas relevantes para la investigación y para la docencia. Para facilitar a nuestros letores en su selección, a continuación, presentamos brevemente los artículos que componen este número de la revista
Matlab_void_evolution_NH_JCNF_MD_JARM_GV
No full textThis dataset contains the MATLAB code employed for calculating the evolution of the void volume fraction and reconstructing the void geometry. The code utilizes the Quickhull algorithm to determine the smallest convex set encompassing the coordinates of the nodes constituting the void surface.
Reference:
Hosseini, N., Nieto-Fuentes, J.C. (CA), Dakshinamurthy, M., Rodríguez-Martínez, J.A., Vadillo, G. (2022). The effect of material orientation on void growth. International Journal of Plasticity, 148, 103149. DOI: 10.1016/j.ijplas.2021.103149
L'arte della ragionevole menzogna
No full textL’articolo è il resoconto di una lezione-tipo, tenuta in collaborazione dai due autori, pensata come propedeutica e introduttiva al corso per affrontare con gli studenti uno dei problemi fondativi delle poetiche d’autore. Prendendo a esempio diversi testi della tradizione letteraria e figurativa, si propone il tema del rapporto tra verità e menzogna, finzione e realtà, palcoscenico e platea, per far rilevare quanto il gioco del linguaggio possa essere più serio (e utile) di quanto appaia
VISdish: A new tool for canting and shape-measuring solar-dish facets
No full textSolar dishes allow us to obtain highly concentrated solar fluxes used to produce electricity or feed thermal processes/storage. For practical reasons, the reflecting surface is composed by a number of facets. After the dish assembly, facet-canting is an important task for improving the concentration of solar radiation around the focus-point, as well as the capture ratio at the receiver placed there. Finally, flux profile should be measured or evaluated to verify the concentration quality. All these tasks can be achieved by the new tool we developed at ENEA, named VISdish. The instrument is based on the visual inspection system (VIS) approach and can work in two functionalities: canting and shape-measurement. The shape data are entered in a simulation software for evaluating the flux profile and concentration quality. With respect to prior methods, VISdish offers several advantages: (i) simpler data processing, because light point-source and its reflections are univocally related, (ii) higher accuracy. The instrument functionality is illustrated through the preliminary experimental results obtained on the dish recently installed in ENEA-Casaccia in the framework of the E.U. project OMSoP. © 2017 Author(s)
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