1,450 research outputs found

    Synthesis of new 2-phospono-a-D-glycoside derivatives by stereoselective oxa-Michael addition to a D-galacto derived enone

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    The synthesis of new 2-phosphono-a-D-glycoside derivatives by stereoselective oxa-Michael addition to an enone derived from D-galactal and containing a phosphonate group is described. Retro-Michael reactions were prevented by tandem acetylation to trap the unstable enolic intermediates. The stereochemistry of the addition products was established by NOESY experiments and explained with molecular mechanics (MM) and density functional theory (DFT) calculations

    David Audretsch: A Source of Inspiration, a Co-author, and a Friend

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    In this chapter, Enrico Santarelli discusses the profound impact that David had on his career. Beginning with a conference in Budapest, Santarelli and David bocame close friends and colleagues. They went on to collaborate on many papers and projects, several of which Santarelli highlights below

    Dialogo con Enrico Palandri

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    A conversation with Enrico Palandri aimed at contextualizing his work as an author

    Enrico Cattaneo : Fotografare un'idea

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    Oltre ad aver raccontato l’arte e gli artisti del secondo Novecento attraverso la documentazione di cinquant’anni di mostre, studi e grandi manifestazioni pubbliche in Italia, Enrico Cattaneo (Milano, 1933-2019) ha sviluppato una personalissima ricerca visuale sui modi, i soggetti e i materiali della fotografia. Questi due aspetti della sua attività, inseparabili fra loro come le due facce di una medaglia, si ricompongono nella fisionomia unitaria di un autore capace di mettere in questione i presupposti tecnici e concettuali del linguaggio fotografico. Come lui stesso ha scritto: “L’opera d’arte contemporanea è spesso una cosa più un’idea... Difficile fotografare un’idea”.In addition to having chronicled art and artists of the second half of the 20th century by documenting fifty years of exhibitions, art research, and major public events in Italy, Enrico Cattaneo (Milan, 1933–2019) developed a highly personal visual investigation on the modes, languages, and materials of photography. These two facets of his activity, indissolubly linked like the two sides of a coin, are recomposed in the overall profile of an author capable of questioning the technical and conceptual foundations of photography. As he himself has written: ‘The contemporary work of art is often made up of a tangible thing and an idea ... It is difficult to capture an idea on film.

    Factors associated with psychotic symptoms among a sample of male prisoners with substance use disorder: A cross-sectional study

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    Background: Prisoners have a higher prevalence of substance use disorder (SUD) than the nonincarcerated population. Many studies report that an SUD increases the likelihood of psychotic symptoms/disorders. Inmates, therefore, may be at higher risk for psychotic disorders. Objective: The main objectives of this study were to (1) estimate the prevalence of psychotic symptoms in a sample of male inmates with high levels of SUD and (2) verify if type of abuse or other sociodemographic/clinical features are risk factors of psychotic symptoms. In light of the high prevalence of childhood trauma (CT) among inmates, a further objective was to 3) assess whether exposition to CT can predict psychotic symptoms. Method: We included three hundred and nineteen male prisoners, admitted to Monza prison between January 2017 and March 2019. We interviewed participants to collect sociodemographic and clinical information. We administered the Brief Psychiatric Rating Scale (BPRS) and the Drug Abuse Screening Test (DAST) to assess the presence of psychotic symptoms and SUD, respectively. Inmates also completed the Childhood Trauma Questionnaire (CTQ). Results: Data were available for 141 inmates. Forty-five prisoners (31.9%) had psychotic symptoms. Multivariate logistic regression analysis showed that a history of previous incarceration (aOR = 2.98, p = 0.034), opioid abuse (aOR = 5.02, p = 0.008), suicide attempts (aOR = 5.55, p < 0.001), and childhood emotional abuse (aOR = 4.11, p = 0.027) significantly increased the likelihood of psychotic symptoms. Conclusions: Psychotic symptoms are widespread among inmates and are associated with specific risk factors. Prison and jail staff should screen for these factors at the start of an inmate's detention to identify subjects at risk of psychotic symptoms

    Biomarkers of Suicidal Behaviors : A Comprehensive Critical Review

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    Suicide is a relevant worldwide public health problem. Many studies have shown that different demographic and clinical factors are potentially associated with suicidal behavior. Other studies have reported data about the role of biomarkers in the onset of suicidal behaviors. Specifically, researchers have found that suicidal risk may be increased by abnormalities in serotonergic system, hypothalamic-pituitary-adrenal axis, lipid metabolism, immune system and neuronal plasticity. The identification of specific biological parameters associated with self-harm may be helpful to implement prevention strategies and also to detect new therapeutic strategies. In this review, we summarize and analyze the results of main studies about neurobiological mechanisms related to suicidal behavior, also exploring the possible interconnection between the different biological systems

    Effectiveness of yoga as a complementary therapy for anorexia nervosa: a systematic review

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    Anorexia nervosa (AN) is a severe psychiatric condition associated with high disability and mortality. The purpose of the present manuscript is to critically summarize evidence about the effectiveness of yoga for this condition. A bibliographic search was conducted in the main database sources (PubMed, Embase, and Scopus). Articles in English about the effectiveness of yoga in AN were included. Two hundred thirty‐three articles were initially identified and 5 articles were included in the present review. With the exception of one study, all had several methodological limitations such as the presence of confounding factors (e.g., psychiatric comorbidity) or a too limited sample of patients. However, globally yoga seems to ameliorate AN symptoms, especially those regarding emotional dysregulation. Yoga is a candidate complementary treatment for the management of AN, but more randomized controlled studies with larger samples and limited bias are necessary to draw robust conclusions. It would be also interesting to verify in comparative trials the effectiveness of yoga with respect to other treatments such as psychotherapy or the administration of pharmacological compounds. Finally, the practice should be modified adapting to the specific needs of this type of patient

    Paolo Enrico Arias in Abruzzo

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    The author emphasizes P.E.Arias' contribution to archaeological researches in the Abruzzi, thanks to the Pisan Archaeological Mission at Collelongo (AQ)

    Sade : opus contra theatrum

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    Depuis 1999, date à laquelle il annonce son intention d’entamer un cycle de création ayant pour base les oeuvres du marquis de Sade, Enrico Frattaroli a créé 5 spectacles formant un ensemble intitulé Sade convivium. Dans le document qu’il a préparé pour L’Annuaire théâtral, il explique la démarche artistique singulière par laquelle il utilise la matière sadienne tout en évitant de mettre en scène à la fois son théâtre et son oeuvre romanesque.Since 1999, the date he announced his intention to write a cycle of plays based on the works of the Marquis de Sade, Enrico Frattaroli has created five works in this ensemble that bears the title The Sade convivium. In the document he has prepared for L’Annuaire théâtral, he explains his unique approach whereby he uses the works of Sade as a creative material rather than attempting to produce the plays or the novels of the French author

    Una mirada desde la memoria a dos experiencias de teatros políticos locales. : En torno de los escritos dramáticos libertarios de Enrico Giulio

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    After considering the political background of Argentina during the three first decades of the xxth century, the author analyzes a very interesting example of anarchist theatre: Falsas promesas, one of the dramatic texts of Enrico Giulio, ceramist worker and libertarian poet.Después de considerar el trasfondo político argentino de las tres primeras décadas del siglo XX, el autor analiza una interesante ejemplo del teatro anarquista: Falsas promesas, uno de los textos dramáticos de Enrico Giulio, obrero ceramista y poeta libertario
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