1,721,198 research outputs found
Kidney stones and hypertension: an independent clinical association in a population-based study
No full textKidney stones and hypertension: an independent clinical association in a population-based study
No full textA community programme to reduce salt intake and blood pressure in Ghana
Full text linkBackground
In Africa hypertension is common and stroke is increasing. Detection, treatment and control of high blood pressure (BP) is limited. BP can be lowered by reducing salt intake. In Africa salt is added to the food by the consumer, as processed food is rare. A population-wide approach with programmes based on health education and promotion is thus possible.
Methods
We carried out a community-based cluster randomised trial of health promotion in 1,013 participants from 12 villages (628 women, 481 rural dwellers); mean age 55 years to reduce salt intake and BP. Average BP was 125/74 mmHg and urinary sodium (UNa) 101 mmol/day. A health promotion intervention was provided over 6 months to all villages. Assessments were made at 3 and 6 months. Primary end-points were urinary sodium excretion and BP levels.
Results
There was a significant positive relationship between salt intake and both systolic (2.17 mmHg [95% CI 0.44 to 3.91] per 50 mmol of UNa per day, p < 0.001) and diastolic BP (1.10 mmHg [0.08 to 1.94], p < 0.001) at baseline. At six months the intervention group showed a reduction in systolic (2.54 mmHg [-1.45 to 6.54]) and diastolic (3.95 mmHg [0.78 to 7.11], p = 0.015) BP when compared to control. There was no significant change in UNa. Smaller villages showed greater reductions in UNa than larger villages (p = 0.042). Irrespective of randomisation, there was a consistent and significant relationship between change in UNa and change in systolic BP, when adjusted for confounders. A difference in 24-hour UNa of 50 mmol was associated with a lower systolic BP of 2.12 mmHg (1.03 to 3.21) at 3 months and 1.34 mmHg (0.08 to 2.60) at 6 months (both p < 0.001).
Conclusion
In West Africa the lower the salt intake, the lower the BP. It would appear that a reduction in the average salt intake in the whole community may lead to a small but significant reduction in population systolic BP
Commentary : controversies in NICE guidance on lipid modification for the prevention of cardiovascular disease
Full text linkThe new guidelines from the National Institute for Health and Clinical Excellence (NICE) on lipid modification for the prevention of cardiovascular disease will guide the way we assess cardiovascular risk and treat lipids, both in primary and in secondary care. What are the new aspects, and what is it that might spark controversy in this new publication
Uric acid metabolism and tubular sodium handling: results from a population-based study"
No full textEthnic variation in levels of circulating IgG autoantibodies to oxidised low-density lipoprotein
No full textBACKGROUND: Oxidised low-density lipoprotein (Ox-LDL) plays a key role in atherosclerosis. Our aim was to determine whether serum autoantibodies against Ox-LDL (Ab Ox-LDL) differ by ethnic group. DESIGN AND METHODS: Soluble serum Ab Ox-LDL levels were measured in 250 white (113 females), 169 African origin (91 females) and 196 South Asian (92 females) individuals from the Wandsworth Heart and Stroke Study (WHSS) population. All were free from coronary heart disease (CHD), stroke, other cardiovascular disease, diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. RESULTS: There were no sex differences in levels of Ab Ox-LDL, but levels were higher in non-smokers (430U/L [95% CI 471-596]) than in smokers (384U/L [316-468]) (p<0.009). Age- and sex-adjusted levels of Ab Ox-LDL were higher in people of African origin and South Asians compared to whites. This difference was maintained in South Asian women following adjustment for multiple risk factors (82% [21-175]; p=0.004). Ab Ox-LDL levels were negatively associated with serum triglycerides and positively associated with sVCAM-1. CONCLUSIONS: Higher IgG Ab to Ox-LDL are associated with higher levels of sVCAM-1 and, are elevated in female South Asian individuals who have an increased risk of atherosclerosis compared to whites
- …
