1,721,093 research outputs found
Premio INARCH Campania Albergo a corte aperta a Castelvolturno
No full textL’albergo, recuperando la tradizione delle masserie di Terra di Lavoro, adotta il tipo della corte aperta e si rapporta al contesto naturale da ri-misurare. Il tipo, quale forma stabile, si specifica di volta in volta adeguandosi al carattere del luogo. La figura a T, con al centro la piscina, compone le camere con accesso dalla corte e loggia privata rivolta all’esterno. L’orizzontalità dei corpi è mitigata da un portico più alto che si amplifica nei due corpi centrali per le attività collettive
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Antipseudomonal and immunomodulatory properties of esc peptides: Promising features for treatment of chronic infectious diseases and inflammation
Full text linkPersistent infections, such as those provoked by the Gram-negative bacterium Pseudomonas aeruginosa in the lungs of cystic fibrosis (CF) patients, can induce inflammation with lung tissue damage and progressive alteration of respiratory function. Therefore, compounds having both an-timicrobial and immunomodulatory activities are certainly of great advantage in fighting infectious diseases and chronic inflammation. We recently demonstrated the potent antipseudomonal efficacy of the antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c, namely Esc peptides. Here, we confirmed this antimicrobial activity by reporting on the peptides’ ability to kill P. aeruginosa once internalized into alveolar epithelial cells. Furthermore, by means of enzyme-linked immunosor-bent assay and Western blot analyses, we investigated the peptides’ ability to detoxify the bacterial lipopolysaccharide (LPS) by studying their effects on the secretion of the pro-inflammatory cytokine IL-6 as well as on the expression of cyclooxygenase-2 from macrophages activated by P. aeruginosa LPS. In addition, by a modified scratch assay we showed that both AMPs are able to stimulate the closure of a gap produced in alveolar epithelial cells when cell migration is inhibited by concentrations of Pseudomonas LPS that mimic lung infection conditions, suggesting a peptide-induced airway wound repair. Overall, these results have highlighted the two Esc peptides as valuable candidates for the development of new multifunctional therapeutics for treatment of chronic infectious disease and inflammation, as found in CF patients
Semi-stationary and dynamic simulation models: A critical comparison of the energy and economic savings for the energy refurbishment of buildings
No full textDynamic modelling and analysis of novel control strategies for modular cogeneration units operation in hospital facility
No full textThermoeconomic analysis of energy saving measures for hospital facilities equipped with trigeneration plants
No full textHospital and health care facilities consume a huge amount of primary energy. The use of a trigeneration plant based on an internal combustion engine is a very common and reliable energy measure, widely adopted and studied, for reducing primary energy consumption and operating costs of this type of user. With the aim of further decreasing the primary energy consumption of hospital/health care facilities, additional retrofit energy measures are usually implemented. The aim of this work is to point out that if the retrofit of the hospital is carried out after the trigeneration plant installation, the possible energy and economic savings are dramatically limited by the trigeneration system. Unfortunately, this is a common mistake performed by system designers and facility managers. Conversely, energy saving measures must be performed before the installation of the trigeneration unit since they dramatically affect the selection of its capacity and operating strategy. Thus, the correct approach should consider the trigeneration unit installation only after a deep and carful energy retrofit of the hospital, allowing one to correctly select the capacity of the trigeneration unit. In order to prove this conclusion, a case study is performed for a real hospital in Italy. Here, a trigeneration unit has been installed and then additional energy saving measures are going to be implemented. This analysis is carried out by means of a dynamic simulation carried out using the TRNSYS software. In addition, each considered energy measure is validated against the measured data. The system was simulated in the present scenario where energy saving measures are implemented in the facility equipped with the trigeneration unit. In addition, the correct scenario was also simulated, calculating energy and economic performance parameters in the case in which such measures were implemented before the installation of the trigeneration unit. The comparison of the results proved that it is crucial to implement such energy saving measures before designing and installing the trigeneration unit
Polygeneration
No full textThis chapter aims at presenting the basic definitions and classifications for polygeneration systems by especially focusing on the type of layout, fuel, type of by-product, and energy vectors. The chapter provides a comprehensive and detailed discussion on the state of the art of the polygeneration system concept, fueled by fossil fuels and/or renewable energy sources, by presenting the innovative layouts designed to maximize the utilization of the input fuels. Polygeneration systems allow one to simultaneously generate energy vectors (power, heating, and cooling) as well as other valuable products (hydrogen, syngas, biodiesel, fertilizers, drinking water, etc.) by converting one or multiple energy sources. In this framework, different energy fuels can be considered as the supply source of polygeneration systems: fossil fuels (natural gas, coal, hydrogen, etc.) and renewable sources (geothermal, solar, biomass, wind, hydro). The contribution of polygeneration to the development of both centralized and decentralized systems is presented. The pros and cons of these plants are discussed in detail
Combined cooling, heat, and power systems
No full textCombined cooling, heating, and power (CCHP), or trigeneration system, represents the common basis on which most polygeneration systems are conceived: in fact, electric energy, heating, and cooling are the main forms in which energy is used in residential, commercial, and office buildings, as well as in industrial processes
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