325,551 research outputs found
Le disfunzioni sessuali femminili. (2011). in 2011, Atti Terze Giornate Sarde di Scienze Ostetriche e Ginecologiche, Dessole S, Melis GB, Capobianco G eds. Sassari, 11-14 maggio 2011, Atto di congresso, NOSET , Atti Terze Giornate Sarde di Scienze Ostetriche e Ginecologiche, Sassari, Alghero, Italia, 11-14 maggio 2011, Vol ,p. -
No full textPostpartum hemorrhage and emergency hysterectomy in a patient with mitochondrial myopathy: a case report.
No full textArch Gynecol Obstet. 2003 Feb;267(4):247-9. Epub 2002 Sep 26.
Postpartum hemorrhage and emergency hysterectomy in a patient with mitochondrial myopathy: a case report.
Dessole S, Capobianco G, Ambrosini G, Battista Nardelli G.
SourceDepartment of Pharmacology, Gynecology and Obstetrics, 07100 Viale San Pietro 12, Sassari, Italy. [email protected]
Abstract
Mitochondrial myopathies are a rare biochemical group of disorders of the mitochondrial respiratory chain. We report the first case in the literature of a pregnant woman with mitochondrial myopathy who, after cesarean section, had a severe and massive postpartum hemorrhage that required emergency supracervical hysterectomy. We discuss the case and review the literature
Test combinato nel I trimestre di gravidanza per lo screening delle anomalie cromosomiche: outcome dei bambini con BITEST positivo. (2009). in 2009, Atti Seconde Giornate Sarde di Scienze Ostetriche e Ginecologiche, Dessole S, Melis GB, Capobianco G eds. Sassari, 14-16 maggio 2009, Atto di congresso, NOSET , Vol ,p. 411 - 416
No full textCESAREAN SECTION: PAST, PRESENT AND FUTURE
No full textCaesarean section is a surgical procedure of ancient origins: it was performed to extract the baby after the woman had died. Today, cesarean section is necessary when vaginal birth is not possible or poses the mother or the child at high risk. In the last thirty years, this procedure has been increasingly used, particularly in Western countries, with values ranging from 14% in the Scandinavian countries to 30-35% in the USA and approximately 38% of deliveries in Italy. The increase in delivery by caesarean section is due to several factors: the progress of anesthetic techniques and surgical procedures, advanced maternal age of first delivery (32 years in the third millennium), growing medical litigation and the consequent use of defensive medicine [1-3]. Furthermore, other causes include the organization of hospitals, with the Healthcare system paying higher refunds for caesarean sections compared to natural deliveries, and the right of women to avoid pain and give birth “on request” by caesarean section. In this study we analyzed the characteristics of all patients who underwent caesarean section at the Maternal University Hospital in Sassari in 2014. This hospital is a third-level of high specialization, attracting pregnant patients from central and northern areas of Sardinia. Mothers who had a caesarean section were older and had on average a higher education level (over 78% had a high school degree, a bachelor’s or master’s degree) compared to women who gave birth by vaginal delivery. Moreover, they often lived in towns of Central and Northern Sardinia referring to hospitals without a neonatal intensive care unit, and they were then admitted to our Clinic for severe diseases of prematurity needing a fast and safe delivery, namely caesarean section. In the future, particularly in industrialized countries, it will be possible to contain the prevalence of cesarean section within the current percentage (38%), but it will probably not be reduced. In fact, several factors related to global social and cultural changes will be likely to play a role, such as a very low birth rate (around 1 child per couple), an average older age of first pregnancy (related to high levels of education and career), and a greater degree of self-determination in choosing the mode of delivery compared to the past. In the present circumstances, caesarean section should not be demonized, as with its low anesthetic and surgical risk it guarantees a safe childbirth for both mother and child.
REFERENCES
[1] Capobianco G, Balata A, Mannazzu MC, Oggiano R, Pinna Nossai L, Cherchi PL, Dessole S. Perimortem cesarean delivery 30 minutes after a laboring patient jumped from a fourth-floor window: baby survives and is normal at age 4 years. Am J Obstet Gynecol. 2008;198(1):e15-6.
[2] Capobianco G, Angioni S, Dessole M, Cherchi PL. Cesarean section: to be or not to be, is this the question? Arch Gynecol Obstet. 2013;288(2):
461-2.
[3] Dessole S, Cosmi E, Balata A, Uras L, Caserta D, Capobianco G, Ambrosini G. Accidental fetal lacerations during cesarean delivery: experience in an Italian level III university hospital. Am J Obstet Gynecol. 2004;191(5):1673-7
PHOTOACID SWITCHING IN FUSED-RING N-RICH AROMATICS
No full text[1,2,4]triazolo[3,2-c][1,2,4]triazole is a simple fused-ring N-rich aromatic
system, with remarkable properties with respect to acid-base behavior and
tautomerism1-3. Neutral heterobicycles (HL) exhibit amphoteric behaviour
(they can deliver the N−H proton forming the conjugated base L-
and can
accept up to two protons, forming the species H2L+
and H3L++) and show an
unprecedented tautomeric switching upon protonation, as revealed by single
crystal X-ray analysis and confirmed by theoretical calculations4
. By
varying the groups attached at the heterocycle, a remarkable shift of pKai
values, up to 5-6 units, is observed. The studies of the acid-base properties
in the excited state show that the N-H group in neutral triazolo-triazoles has
an intrinsic photobasic behavior. Singly protonated forms of the system
have instead a photoacid behavior. If a photoacid phenol group is attached at
position 7 of the intrinsically photobasic triazolo-triazole unit, the
interaction between the two complementary photoactive functions in the
same molecule is additive, in such a way that in the ground state N-H is
more acid than O-H while the opposite holds in the excited state. So,
between ground and excited state, the acid proton is delivered by different
sites of the same molecule (photoacid switching).
[1] C-H Zhou, Y. Wang,Current Medicinal Chemistry,19 (2012) N.2, 239-
280.
[2] Y. Murti at all, American Journal of Chemistry1 (2011) 42-46.
[3] R. Centore, S. Fusco, A. Capobianco,V. Piccialli, S. Zaccaria, and A.
PelusoEuropean Journal of Organic Chemistry18 (2013) 3721-3728.
[4] R. Centore, C. Manfredi, S. Fusco, C. Maglione, A. Carella, A.
Capobianco, A. Peluso, D. Colonna, A. Di Carlo,Journal of Molecular
Structure 1093 (2015) 119–124
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