132,907 research outputs found
Double-inhibitor and uncoupler-inhibitor titrations. 2. Analysis with a nonlinear model of chemiosmotic energy coupling.
No full textThe results of double-inhibitor and uncoupler-inhibitor titrations have been simulated and analyzed with a nonlinear model of delocalized protonic coupling obtained by linking two proton pump models of the kind studied by Pietrobon and Caplan [Pietrobon, D., & Caplan, S. R. (1985) Biochemistry 24, 5764-5776] through their common intermediate delta mu H. It is shown that the results predicted by a delocalized chemiosmotic model are highly dependent on the kind of relationships existing between rate of ATP synthesis, Jp, and delta mu H and rate of electron transfer, Je, and delta mu H. With nonlinear flow-force relationships all the results reported so far are not necessarily inconsistent with the delocalized chemiosmotic model provided that the relationships between rates and delta mu H satisfy the following requirements: Jp/delta mu H increases and/or Je/delta mu H decreases as (delta mu H) increases
Total Synthesis of Divergolides E and H and an Investigation into the Oxidative Rearrangement to Divergolides C and D
No full textThis thesis describes the first total syntheses of divergolides E and H. Construction of the core bridged bicyclic acetal unit was accomplished using a hetero-Diels–Alder (HDA) reaction and oxidative carbon-hydrogen bond cleavage to couple two highly functionalized subunits. Additional highlights of this convergent synthesis include a chelation-controlled alkenylzinc addition, amide formation between a hindered aniline and an acylating agent prone to ketene formation, and a challenging macrolactonization. Model studies showed effective oxidation of the core structure using a hypervalent iodine species which sets the stage for rearrangement into divergolides C and D
Subjective Versus Objective: An Exploratory Analysis of Latino Primary Care Patients With Self-Perceived Depression Who Do Not Fulfill Primary Care Evaluation of Mental Disorders Patient Health Questionnaire Criteria for Depression
No full textObjective: Identification and treatment of depression may be difficult for primary care providers when there is a mismatch between the patient’s subjective experiences of illness and objective criteria. Cultural differences in presentation of symptoms among Latino immigrants may hinder access to care for treatment of depression. This article seeks to describe the self-perceptions and symptoms of Latino primary care patients who identify themselves as depressed but do not meet screening criteria for depression.
Method: A convenience sample of Latino immigrants (N = 177) in Corona, Queens, New York, was obtained from a primary care practice from August 2008 to December 2008. The sample was divided into 3 groups according to whether participants met Patient Health Questionnaire diagnostic criteria for depression and whether or not participants had a self-perceived mental health problem and self-identified their problem as “depression” from a checklist of cultural idioms of distress. Psychosocial, demographic, and treatment variables were compared between the 3 groups.
Results: Participants’ descriptions of symptoms had a predominantly somatic component. The most common complaints were ánimo bajo (low energy) and decaimiento (weakness). Participants with “subjective” depression had mean scores of somatic symptoms and depression severity that were significantly lower than the participants with “objective” depression and significantly higher than the group with no depression (P < .0001).
Conclusions: Latino immigrants who perceive that they need help with depression, but do not meet screening criteria for depression, still have significant distress and impairment. To avoid having these patients “fall through the cracks,” it is important to take into account culturally accepted expressions of distress and the meaning of illness for the individual.Peer reviewe
D. Bell, P. Caplan & W. J. Karim, Gendered Fields. Women, Men and Ethnography
No full textErny Pierre. D. Bell, P. Caplan & W. J. Karim, Gendered Fields. Women, Men and Ethnography. In: L'Homme, 1995, tome 35 n°135. La formule canonique des mythes. pp. 136-137
D. Bell, P. Caplan & W. J. Karim, Gendered Fields. Women, Men and Ethnography
No full textErny Pierre. D. Bell, P. Caplan & W. J. Karim, Gendered Fields. Women, Men and Ethnography. In: L'Homme, 1995, tome 35 n°135. La formule canonique des mythes. pp. 136-137
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Caplan-Syndrom: eine untypische Differenzialdiagnose des «pulmorenalen» Syndroms
No full textRheumatoide Pneumokoniose, auch Caplan-Syndrom genannt, kann bei Personen mit Exposition gegenüber anorganischen Stäuben wie z.B. Silikate, Kohlenstaub und Asbest vorkommen und die Lebensqualität und -erwartung signifikant einschränken. Wegen ihrer Seltenheit kann die Erkrankung verkannt werden. Eine sorgfältige Erhebung der Berufsanamnese ist für die Diagnosestellung wichtig
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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