1,720,961 research outputs found
Genetic modulation of anti-inflammatory effects of atorvastatin; probably a multi-gene condition
No full textPersistent angina
No full textWe are witnessing an exponential increase in the use of percutaneous transluminal coronary angioplasty (PTCA) for the treatment of coronary heart disease. Given that available evidence does not support a significant reduction of morbidity or mortality after PTCA, the widespread use of revascularization procedures is based on the assumption of a superior symptomatic relief of angina and on improved exercise tolerance. Unfortunately, randomized controlled trials suggest that symptomatic relief after PTCA may be partial, and limited in time. Several studies have shown that patients may remain symptomatic for angina even after removal of coronary obstructions. This observation challenges the assumption that coronary stenosis is the only cause of angina and calls for innovative therapeutic approaches, independent of the classic agents developed to counteract the adverse effects of flow-limiting coronary obstructions
The rationale of metabolic treatment in ischaemic heart disease
No full textIschaemic heart disease remains the leading cause of death in the western world and jeopardize quality of life in millions people. PTCA plus medical therapy can control symptoms in most patients with stable angina. However, many trials consistently report persistance of angina and/or ischemia in one third of patients. Awareness of the limited benefit from standard treatments is increasing and stimulates the search for innovative approaches. Improved understanding of cardiac energy metabolism offers promising alternatives and new solution to the problem. A partial shift from free fatty acid to glucose oxidations has been shown to improve cardiac efficiency and to increase tolerance to ischaemia. Large clinical trias based on metabolic agents are warrante
Persistent angina after myocardial revascularization:a case report
No full textA 56-year-old woman with stable angina was admitted to our Cardiology Department; because of the presence of symptoms and signs of ischemia during a stress test she was a candidate for coronary evaluation. At 1 and 6 months of follow up, despite a complete coronary revascularization, the patient continued to complain of angina; stress testing continued to show signs of myocardial ischemia. This is an example of an individual with persisting angina despite "successful" coronary myocardial revascularization
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
