169,932 research outputs found
Ensaios sobre Strawson
No full textTradução para o português do livro "Ensaios sobre Strawson", de Carlos Caorsi. Editora da unijuí, 2014. Sumário: Apresentação; A teoria da verdade em Strawson, Mauricio Beuchot; Réplica a Mauricio Beuchot, Peter F. Strawson; Strawson: entre a lógica tradicional e a lógica clássica, Robert Calabria; Réplica a Robert Clabria, Peter F. Strawson; Referência e termos singulares, Carlos E. Caorsi; Réplica a Carlos E. Caorsi, Peter F. Strawson; Strawson e a metafísica, Juan C. D’Alessio; Réplica a Juan C. D’Alessio, Peter F. Strawson; A meta-metafísica de Strawson: identificação versus individuação, Jorge J. E. Gracia; Réplica a Jorge J. E. Gracia, Peter F. Strawson; Algumas distinções sobre a noção de indivíduo, Jesús Mosterín; Réplica a Jesús Mosterín, Peter F. Strawson; Sobre a percepção e seus objetos em Strawson, Ernest Sosa; Réplica a Ernest Sosa, Peter F. Strawson; Limitações ao exercício da perplexidade, Teresa de Jesús Zavalía; Réplica a Tereza de Jesús Zavalía, Peter F. Strawson; Publicações de P. F. Strawson
Successful treatment of co-existent SAPHO syndrome and hidradenitis suppurativa with adalimumab and methotrexate
No full textSAPHO syndrome, namely Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis, is a rare autoinflammatory chronic disease presenting with non-infectious inflammatory osteitis, sterile joint inflammation and skin manifestations, including palmoplantar pustulosis and severe acne. The case of a 15-year-old boy affected by SAPHO syndrome and hidradenitis suppurativa (HS) is presented and discussed. Coexistence of these two diseases may represent a therapeutic challenge and this case confirms literature data reporting the efficacy of the combination of methotrexate and adalimumab in SAPHO complicated by HS
Complications of severe acute respiratory syndrome coronavirus 2 infection in children
No full textPurpose of review Although during the initial stages of COVID-19 pandemic, the pediatric population seemed to be less affected, a number of SARS-CoV-2-related manifestations emerged over time, the principal of which is the multisystem inflammatory syndrome in children (MIS-C). Here we provide an update on the main pediatric disorders associated with SARS-CoV-2 infection. Recent findings MIS-C is novel postinfectious manifestation with clinical features similar to Kawasaki disease and characterized by intense systemic inflammation affecting multiple organs. Many children required intensive care therapy because of circulatory shock, usually of myocardial origin. Appropriate treatment with immunomodulatory therapies led to favorable outcomes in most patients, with recovery of overall health and cardiac dysfunction. In addition to MIS-C, a variety of other complications of COVID-19 in children have been described, including thrombotic events, neurologic manifestations, and chilblain-like lesions. There is still uncertainty about the true prevalence of long COVID in children and its distinction from pandemic-related complaints. The experience gained so far with MIS-C and the other SARS-CoV-2-related complications in children and adolescents will facilitate accurate diagnosis and appropriate treatment. Further studies are needed to elucidate the pathophysiology of MIS-C and to determine the real impact of long-COVID in the pediatric age group
Homological S-Duality in 4d N=2 QFTs
No full textThe S[duality group S[double-struck](F) of a 4d N = 2 supersymmetric theory F is identified with the group of triangle equivalences of its cluster category C (F) modulo the subgroup acting trivially on the physical quantities. S[double-struck](F) is a discrete group commensurable to a subgroup of the Siegel modular group Sp(2g,) (g being the dimension of the Coulomb branch). This identification reduces the determination of the S-duality group of a given N = 2 theory to a problem in homological algebra. In this paper we describe the techniques which make the computation straightforward for a large class of N = 2 QFTs. The group S[double-struck](F) is naturally presented as a generalized braid group. The S-duality groups are often larger than expected. In some models the enhancement of S-duality is quite spectacular. For instance, a QFT with a huge S-duality group is the Lagrangian SCFT with gauge group SO(8) × SO(5)3 × SO(3)6 and half-hypermultiplets in the bi- and tri-spinor representations. We focus on four families of examples: the N = 2 SCFTs of the form (G,G"), Dp(G), and E r(1,1) (G), as well as the asymptoticallyfree theories (G, Ĥ) (which contain N = 2 SQCD as a special case). For the E r(1,1) (G) models we confirm the presence of the PSL(2,) S-duality group predicted by Del Zotto, Vafa and Xie, but for most models in this class S-duality gets enhanced to a larger group
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Trabalho sexual, proxenetismo e prostituição forçada Onde termina o legal e começa o proibido?
No full textEl objetivo del presente artículo consiste en analizar la regulación del trabajo sexual y los delitos de proxenetismo y prostitución forzada, a los efectos de determinar qué es lo que la ley permite y prohíbe en relación a la industria del sexo. Nuestro país cuenta con la Ley N.º 17.515 y su Decreto reglamentario N.º 480/003, que regulan el trabajo sexual; pero a su vez también prohíbe el ejerció del proxenetismo y la prostitución forzada. A través de este análisis crítico, se podrá delimitar la estrecha línea que separa la actividad comercial lícita de montar y lucrar con un prostíbulo (o un establecimiento de similares características) y el delito de proxenetismo, para los cual se analizarán las normas aplicables, la doctrina y la jurisprudencia en la materia.The objective of this article is to analyze the regulation of sex work and the crimes of pimping and forced prostitution, in order to determine what the law allows and prohibits in relation to the sex industry. Our country has Law 17,515 and its regulatory decree 480/003, which regulate sex work; but at the same time, it also prohibits the exercise of pimping and forced prostitution. Through this critical analysis, it will be possible to delimit the narrow line that separates the legal commercial activity of setting up and profiting from a brothel (or an establishment with similar characteristics) and the crime of pimping, for which the applicable norms will be analyzed, the doctrine and jurisprudence on the matter.O objetivo deste artigo é analisar a regulamentação do trabalho sexual e os crimes de lenocínio e prostituição forçada, a fim de determinar o que a lei permite e proíbe em relação à indústria do sexo. Nosso país possui a Lei 17.515 e seu Decreto Regulamentar 480/003, que regulamentam o trabalho sexual; mas ao mesmo tempo também proíbe o exercício de lenocínio e prostituição forçada. Por meio dessa análise crítica, será possível delimitar a estreita linha que separa a atividade comercial legal de montar e lucrar com prostíbulo (ou estabelecimento com características semelhantes) e o crime de lenocínio, para o qual serão analisadas as normas aplicáveis, a doutrina e a jurisprudência sobre o assunto
Multisystem Inflammatory Syndrome in Children: Unique Disease or Part of the Kawasaki Disease Spectrum?
No full textOne of the most intriguing and mysterious phenomena observed during the COVID-19 pandemic has been represented by the occurrence of the multisystem inflammatory syndrome in children and adolescents (MIS-C). Patients with this condition have some overlapping signs and symptoms with those of Kawasaki disease (KD), but also display clinical features that are uncommon or less frequent in this illness, such as diarrhea, abdominal pain and myocardial involvement. The sickest patients may develop multiorgan failure and shock, usually due to myocarditis. Management is based on the administration of intravenous immunoglobulin, glucocorticoids and, in the most severe instances, anakinra. It is still debated whether MIS-C and KD represent different illnesses or are part of the same disease spectrum. The aim of the present review is to analyze critically the evidence in favor of the latter hypothesis and to provide the authors' personal interpretation of the relationship between the two conditions
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Timely Recognition and Early Multi-Step Antinflammatory Therapy May Prevent ICU Admission of Patients With MIS-C: Proposal for a Severity Score
No full textIn this observational study, we report the clinical, therapeutics and outcome features of 23 patients with multisystem inflammatory syndrome (MIS-C) who have been treated in Gaslini Children Hospital (Genoa, Italy) with a multistep antinflammatory treatment protocol, based on disease severity at admission. Patients were initially assigned to four severity classes on admission and treated accordingly. The therapeutic options ranged from IV immunoglobulin alone to a combination of IVIG plus pulses of methylprednisolone plus anakinra for patients with marked cardiac function impairment or signs of macrophage activation syndrome, with rapid treatment escalation in case of inadequate therapeutic response. With the application of this therapeutic strategy, no patient required admission to Intensive Care Unit (ICU) or invasive mechanical ventilation, and no inotropic drugs administration was required. Early aggressive treatment of MIS-C, with therapeutic interventions modulated based on the severity of clinical manifestations may help to prevent the progression of the inflammatory process and to avoid the need of admission to the ICU. A timely intervention with anti-IL-1 blockers can play a pivotal role in very severe patients that are at risk to have an incomplete response to immunoglobulins and steroids
Incidence rate of MIS-C in paediatrics: A good reason to vaccinate children against SARS-CoV-2
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