189 research outputs found
Combining Acceleration Techniques for Pricing in a Vrp With Time Windows
No full textHande Küçükaydın (MEF Author)##nofulltext##..
Column Generation Based Algorithms for a Vrp With Time Windows & Variable Departure Times
No full textHande Küçükaydın (MEF Author)##nofulltext##..
From Thread to Fabric: Anthropology and Its Interpreters
No full textIn the Conclusion of the book edited by Hande Birkalan Gedik and Fabiana Dimpfelmeier, the author traces the dynamics between the thread and the fabric, going back to Fredric Barth's seminal 2000 Sydney Mintz lecture, published in 2002. Using different examples, from ideas that speak of global anthropological concerns, to the more particular issues of what it means to produce (and use) the anthropological knowledge, the chapter emphasizes the need to understand different regional traditions.This open access edition of ‘Fabrics of Anthropological Knowledge: Changing Perspectives in Europe and Beyond’,
edited by Hande Birkalan-Gedik and Fabiana Dimpflmeier has been funded by Georg und Franziska Speyer’sche
Hochschulstiftung and the Open Access Publication Fund of Goethe University Frankfurt am Main
Correction to: Digitalization of Business Logistics Activities and Future Directions
No full textThe original version of Chapter 10 was inadvertently published with the incorrect authors affiliation. For authors Ebru Beyza Bayarçelik and Hande Begüm Bumin Doyduk the corrected affiliation is provided below: Ebru Beyza Bayarçelik Department of International Trade and Logistics Management, Faculty of Business and Management Science, Maltepe University, Maltepe, Istanbul, Turkey e-mail: [email protected] Hande Begüm Bumin Doyduk Hande Begüm Bumin Doyduk (Corresponding author), Department of International Trade, School of Business, Altınbaş University, Esentepe, Istanbul, Turkey e-mail: [email protected] Corrections have been updated in the book. © Springer Nature Switzerland AG 2020
Seller's liability for defected goods under the Turkish Code of Obligations and the Vienne Sales Convention and particularly buyer's right to claim damages under the Vienne Sales Convention
No full textBu çalışma, Özyeğin Üniversitesi Sosyal Bilimler Enstitüsü'nde yüksek lisans tezi olarak hazırlanmıştır. Tezde araştırılan konu, Viyana Satım Sözleşmesi ve Türk Borçlar hukuku açısından ayıplı ifadan dolayı alıcının sahip olduğu seçimlik haklar ve özellikle Viyana Satım Sözleşmesi'ne göre önemli bir hak olan tazminat hakkıdır. Giriş bölümünde konunun seçimindeki etkenler ve inceleme tarzı, terminoloji tercihi ele alınmıştır. Birinci bölümde Viyana Satım Sözleşmesi'nin uygulama alanı, yer bakımından, maddi bakımdan ve zaman bakımından ele alınmış ve sonrasında Türk Borçlar Kanunu ile Viyana Satım Sözleşmesi uyarınca ayıptan doğan sorumluluk karşılaştırmalı olarak incelenmiştir. İkinci bölümde, alıcının Viyana Satım Sözleşmesi uyarınca ayıplı ifa sonucu tazminat talep etme hakkı ayrıntılı olarak incelenmiştir. Sonuç bölümündeyse, tezde araştırılan konular ve yapılan çıkarımlar bir arada sunulmuştur. Anahtar Kelimler: Viyana Satım Sözleşmesi, VSS, Ayıptan Doğan Sorumluluk, Tazminat.This study is prepared as a Master of Laws thesis for the Institute of Social Sciences at Ozyegin University. This thesis focuses on the buyer's remedies against seller for product liability, particularly the right to compensation according to the United Nations Convention on Contract for the International Sale of Goods as well as the Turkish Code of Obligations. The introduction focuses on the main reasons and influences that led to the selection of this research subject as well as the research methods that were used within this study and explains the preference of terminology. The first chapter consists of the analysis of the ratione materiae and ratione temporis scopes of the UN Convention on Contract for the International Sale of Goods as well as a comparative analysis as regards to the liability for defective products according to the Turkish Code of Obligations and the UN Convention on Contract for the International Sale of Goods. The second chapter assesses in great detail the buyer's claim for compensation in cases of product liability according to the UN Convention. Lastly, the conclusion provides a holistic evaluation consisting of the research subjects within this study as well as the final deductions and notes of the author of this thesis. Keywords: The United Nations Convention on Contracts for the International Sale of Goods, CISG, Product Liability, Buyer's Remedies, Claim for Compensation
Methionine affects the expression of pluripotency genes and protein levels associated with methionine metabolism in adult, fetal, and cancer stem cells
No full textIntracellular and extracellular regulatory factors promote the potency and self-renewal property of stem cells. Methionine is fundamental for protein synthesis and regulation of methylation reactions. Specifically, methionine metabolism in embryonic and fetal development processes regulates gene expression profile/epigenetic identity of stem cells to achieve pluripotency and cellular functions. We aimed to reveal the differences in methionine metabolism of bone marrow (BM)-mesenchymal stem cells (MSCs), umbilical cord blood (UCB)-MSCs, and cancer stem cells (CSCs), which reflect different metabolic profiles and developmental stages of stem cells. UCB-MSC, BM-MSCs, and breast CSCs were treated with different doses (0, 10, 25, 50, and 100 mu M) of l-methionine. Cell surface marker and cell cycle assessment were performed by flow cytometry. Changes in gene expressions (OCT3/4, NANOG, DMNT1, DNMT3A, and DNMT3B, MAT2A, and MAT2B) with methionine supplementation were examined by quantitative real-time polymerase chain reaction and the changes in histone methylation (H3K4me3, H3K27me3) levels were demonstrated by western blot analysis. S-adenosylmethionine//S-adenosylhomocysteine (SAM/SAH) levels were evaluated by enzyme-linked immunosorbent assay. Cells that were exposed to different concentrations of l-methionine, were mostly arrested in the G0/G1 phase for each stem cell group. It was evaluated that BM-MSCs increased all gene expressions in the culture medium-containing 100 mu M methionine, in addition to SAM/SAH levels. On the other hand, UCB-MSCs were found to increase OCT3/4, NANOG, and DNMT1 gene expressions and decrease MAT2A and MAT2B expressions in the culture medium containing 10 mu M methionine. Moreover, an increase was observed in the He3K4me3 methylation profile. In addition, OCT3/4, NANOG, DNMT1, and MAT2B gene expressions in CSCs increased starting from the addition of 25 mu M methionine. An increase was determined in H3K4me3 protein expression at 50 and 100 mu M methionine-supplemented culture condition. This study demonstrates that methionine plays a critical role in metabolism and epigenetic regulation in different stem cell groups
Does N-Acetyl Cysteine Protect Against Apoptosis in HL60 Cell Line?
No full textObjectives: The primary objective of this study is to determine the role of glutathione depletion and N-acetylcysteine on apoptotic signal formation in HL60 cell line
Hope Speech detection in under-resourced Kannada language
No full text@article{hande-etal-kanhope,
title = "Hope Speech detection in under-resourced Kannada language",
author = "Hande, Adeep and
Priyadharshini, Ruba and
Sampath, Anbukkarasi and
Thamburaj, Kingston Pal and
Chandran, Prabakaran and
Chakravarthi, Bharathi Raja ",
journal={SN Computer Science},
publisher={Springer}
}Numerous methods have been developed to monitor the spread of negativity in modern years by eliminating vulgar, offensive, and fierce comments from social media platforms. However, there are relatively lesser amounts of study that converges on embracing positivity, reinforcing supportive and reassuring content in online forums. Consequently, we propose creating an English-Kannda Hope speech dataset, KanHope and comparing several experiments to provide benchmarking for the dataset. The dataset consists of 6,176 user-generated comments in code mixed Kannada crawled from YouTube and manually labelled as bearing hope speech or not-hope speech. In addition, we introduce DC-BERT4HOPE, a dual-channel model that uses the English translation of KanHopeEDI for additional training to promote hope speech detection. The approach achieves a weighted F1-score of 0.756, bettering other models. Henceforth, KanHope aims to instigate research in Kannada while broadly promoting researchers to take a pragmatic approach towards online content that encourages, positive, and supportive
Ergenlik döneminde eğlence amaçlı esrar kullanımının ve subklinik psikoz riskinin, beynin beyaz madde bütünlüğüne ve yapısal bağlantısına etkisi
No full textCataloged from PDF version of article.Includes bibliographical references (leaves 43-61).The impact of cannabis use on the psychosis risk in the healthy population has been less examined in the literature. Furthermore, previous diffusion tensor imag-ing and structural connectivity studies investigating the effects of cannabis use and psychosis risk offer contradictory results. To address these gaps and inconsistencies in the literature, the author examined whether recreational use of cannabis increases the risk of subclinical psychosis. The author further ex-amined the relationship between recreational cannabis use, subclinical psychosis, and white matter microstructure or structural network connectivity. Twenty-five adolescent cannabis users and 25 demographically matched controls participated in the study. The Cannabis Experience Questionnaire (CEQ) was used to assess cannabis consumption. Subclinical psychosis was evaluated with the Community Assessment of Psychic Experience (CAPE-42) questionnaire. While ROI-based Tract Based Spatial Statistics (TBSS) was used to examine white matter integrity in specified region of interests, Structural Connectivity Analysis was performed to examine brain structural topology. White matter integrity was assessed by four diffusion tensor derived measures: fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity, while structural network topology was examined by several graph-theory metrics: global efficiency, local efficiency and clustering coefficient. In order to eliminate possible confounding effects of alcohol and to-bacco use, weekly alcohol and daily tobacco consumption were also considered. The findings revealed that cannabis users scored higher on subclinical psychosis compared to non-users. ROI-based TBSS analysis indicated that cannabis use and subclinical psychosis do not affect white matter integrity in corpus collosum and superior longitudinal fasciculus. Similarly, the network connectivity parame-ters were not affected by the recreational cannabis use and psychosis risk. These results might indicate that recreational cannabis use increases the psychosis risk in adolescence, but that recreational cannabis use and subclinical psychosis risk together do not affect white matter microstructure and topology.by Hande Ezgi Atmac
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