112,547 research outputs found
Il Parlamento europeo nelle procedure di codecisione: una ricerca empirica
No full textRicerca PRIN coordinata da V. Cannizzaro: coordinatore del gruppo di ricerca di Ferrara avente a titolo: "Il Parlamento europeo nelle procedure di codecisione: una ricerca empirica
Conoscenza, riordino e tutela del territorio nella programmazione e nell'intervento della Regione Sicilia
No full textCannizzaro S. è autore dei due paragrafi IV (La carta dell'uso del suolo) e V (Le aree protette)
Asymmetrische Katalyse der Intramolekularen Cannizzaro-Reaktion
No full textDie optisch aktiven Thiolamine I und II bewirken in methanol. Lösung die Bildung von (+)-Mandelsäure-methylester aus Phenylglyoxal. Die optische Ausbeute betrug maximal 7.7%. Analog der intramolekularen Cannizzaro-Reaktion in Gegenwart von OH-lonen ist die Katalyse der intramolekularen Cannizzaro-Reaktion durch Thiolamine eine irreversibel verlaufende Reaktion
L'avviso di accertamento illegittimo successivamente annullato in esercizio del potere di autotutela
No full text
Clinical evidence on the efficacy and tolerability of a topical medical device containing benzoylperoxide 4%, retinol 0.5%, mandelic acid 1% and lactobionic acid 1% in the treatment of mild facial acne: an open label pilot study
No full textVirginia Garofalo, Maria Vittoria Cannizzaro, Sara Mazzilli, Luca Bianchi, Elena CampioneDivision of Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyBackground: Acne is a debilitating disorder that requires proper treatment depending on the clinical manifestations and pathogenetic factors, among which hyper-keratinization, seborrhea and bacterial proliferation. Combining active ingredients targeting the different mediators of acne pathogenesis may yield optimal outcomes.Purpose: The purpose of this study was to evaluate the clinical effectiveness, safety and tolerability of a new topical medical device in cream containing benzoylperoxide 4%, pure retinol 0.05%, palmitate retinol 0.5%, mandelic acid 1% and glycyrrhetic acid on patients with mild acne.Patients and methods: Twenty consecutive patients of both sexes with mild acne were included in the study. The topical treatment was self-applied twice a day for 12 weeks. Evaluations included: Global Acne Grading System (GAGS); inflammatory and non-inflammatory lesions count; reflectance confocal microscopy; seborrhea and hydration degree; photographic documentation; a questionnaire to assess tolerability.Results: The GAGS score showed a 39% reduction from T0 to T1 and 69.20% from T0 to T2. The count of comedonic lesions showed a 44% reduction from T0 to T1 and 65% from T0 to T2. The count of papular lesions diminished by 49.4% from T0 to T1 and by 62% from T0 to T2. The count of pustular lesions decreased by 43% from T0 to T1 and by 80% from T0 to T2. Improvement of hydration and a decrease of seborrhea degree were even observed. These clinical results were confirmed by reflectance confocal microscopy exam.Conclusion: The topical medical device has shown to be clinically effective and well tolerated for the treatment of mild acne. Side effects were mild, transient and well tolerated. The results of our study demonstrated a high tolerability of this new combination of benzoylperoxide 4% and retinol. Furthermore, our results suggested that the studied compound could be considered as a “maintenance treatment” after specific pharmacological treatment, even in more severe types of acne.Keywords: acne vulgaris, therapeutics, benzoyl peroxide, alpha hydroxide acid, vitamin
Sexually dimorphic effects of alcohol self-administration on cognitive processes
No full textChronic alcohol consumption is able to modify cognitive and emotional behaviour in humans. Many studies on gender diversity have identified swingeing differences between man and woman, not only in the propensity for alcohol abuse, but also in their behavioural effects. In this study we investigate in adult male and female rats:
i) alcohol drinking behaviour and preference pattern using a 3-bottle choice paradigm with water, 10% ethanol solution and white wine (10%v/v), along a four-week period;
ii) Alcohol free access (AFA) effects on locomotion and behavioural reactivity in the Open Field;
iii) The influence of AFA on spatial learning and reference memory, employing the Morris Water Maze.
Our results show that:
1) female rats display higher intake of alcoholic beverages compared to males in the first two weeks of the paradigm, while they reduce their alcoholic intake in the last two weeks, drinking the same amounts as males; female rats- as well as males - prefer ethanol 10% than white wine;
2) AFA increases locomotor activity and behavioural reactivity in response to novelty in male rats (p< 0.004); on the contrary, female rats display a decrease in behavioural reactivity and locomotion compared to controls (p< 0.0187);
3) AFA improves spatial information processing in the new-place learning task in male rats, while it has detrimental effects in place learning, reversal learning and reference memory in female rats.
Our results show a sexually dimorphic pattern of alcohol drinking behaviour, highlighting a different sensitivity to the reinforcing properties of ethanol. Both male and female rats are able to self-regulate their alcoholic intake along the four-week paradigm. The sexually dimorphic different behavioural consequences of alcohol free-access indicate that female rats are more vulnerable to the detrimental effects of alcohol and this may be due to the gender-related differences in metabolic and neurochemical pattern
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