1,721,028 research outputs found
Identification of microRNA expression profile related to lymph node status in women with early-stage grade 1-2 endometrial cancer
No full textLa classification du cancer de l'endomètre, basée sur l'histologie, conditionne la prise en charge thérapeutique alors qu'elle ne montre pas une pertinence suffisante pour prédire l'envahissement ganglionnaire. La détermination de profils d'expression biologiques corrélés au statut ganglionnaire et à d'autres facteurs pronostiques majeurs tels que les emboles apparait donc fondamentale pour mieux adapter la prise en charge. Nous avons montré, par une analyse de puce à partir des ARNs extraits de tissus sous paraffine de cancer de l'endomètre de type endométrioide, de grade 1-2, supposé limité à l'utérus, que les niveaux d'expression de cinq micro-ARNs (miR-34c-5p, -375, -184, -34c-3p, et -34b-5p) étaient plus faibles dans les tissus tumoraux avec envahissement ganglionnaire. Les niveaux d'expression de trois micro-ARNs (miR-34c-5p, -23b-5p, et -23c) étaient plus faibles dans les tissus tumoraux avec emboles lymphovasculaires. Une analyse par RT-qPCR a permis de déterminer des seuils de micro-ARNs corrélés aux facteurs pronostiques. Les patientes avec seuil d'expression du micro-ARN-184 0,30, p=0,006. Les patientes avec seuil d'expression du micro-ARN-34c-5p 0,15 (0,0%), p0.30 (n=3; 11.5%), p=0.006. Women with a microRNA-34c-5p fold change 0.15 (n=0; 0.0%), p<0.001. These microRNA expression profiles may provide a basis for further studies of the micro-RNA function in endometrioid adenocarcinoma, and be used as a diagnostic tool
Détermination sur tissu endométrial néoplasique de profils d'expression de micro-ARNs associés à l'envahissement ganglionnaire dans le cancer de l'endomètre de type endométrioïde de stade précoce
No full textCurrent histological classification of early-stage endometrial cancer (EC) may show insufficient accuracy to precisely predict lymph node metastases leading to potential over or under treatment. Hence, additional highly sensitive and specific molecular prognostic biomarkers correlated with prognostic factors, such as nodal involvement and lymphovascular space involvement (LVSI), are needed to better adapt surgical management and adjuvant therapies. We fstudied by microarray analysis microRNA expression profiles of formalin-fixed paraffin-embedded grade 1–2 supposed early-stage endometrioid adenocarcinomas specimen. The expression levels of 5 microRNAs (miR-34c-5p, -375, -184, -34c-3p, et -34b-5p) were lower in the EC with positive nodal status compared to those with negative nodal status. The expression levels of 3 microRNAs (miR-34c-5p, -23b-5p, et -23c) were lower in the EC with positive LVSI compared to those with negative LVSI. A quantitative reverse transcriptase–PCR assay was used to determine micro-RNAs thresholds correlated with prognostic factors. Women with a microRNA-184-fold change 0.30 (n=3; 11.5%), p=0.006. Women with a microRNA-34c-5p fold change 0.15 (n=0; 0.0%), p0,30, p=0,006. Les patientes avec seuil d'expression du micro-ARN-34c-5p 0,15 (0,0%), p<0,001. Ces profils d'expression de micro-ARNs fournissent les bases pour de nouvelles études sur la fonction des micro-ARNs dans le cancer de l'endomètre et pourraient constituer un nouvel outil au diagnostic du statut ganglionnaire
Complications vasculo-placentaires chez les femmes enceintes infectées par le VIH : une étude cas-témoin
No full textBackground: Data from international literature suggest a link between HIV infection and placental vascular complications during pregnancy. Current studies on the subject are conflicting.Objective: The aim of the study was to evaluate the incidence of placental vascular complications during pregnancy among HIV+ and HIV- patients.Study Design: It is a single-center case-control study comparing the rates of gestational hypertension, preeclampsia, eclampsia and vascular intrauterine growth retardation from 280 HIV+ and 560 HIV- patients matched by age, parity and geographical origin.Results: The rate of placental vascular complications was not statistically different between HIV+ and HIV- patients: 7.5% vs 9.8%, respectively (p = 0.27). HIV+ patients have a significant increase in overall prematurity rate: 18.6% vs 8.0%, p <0.0001 and a significant decrease in birthweight for gestational age: 41.6th percentile vs 46.6th percentile, p = 0.02.Conclusion: This study does not observe difference in the incidence of placental vascular complications between HIV + and HIV- patients. The significant increase in prematurity and low birth weight among HIV + patients has to be explored by further specific studies.Introduction : Les données de la littérature internationale laissent penser qu’il existe un lien entre l’infection VIH et les complications vasculo-placentaires pendant la grossesse. Les études actuelles sur le sujet sont discordantes.Objectif : Le but de l’étude est d’évaluer l’incidence des complications vasculo-placentaires pendant la grossesse entre des patientes VIH+ et des patientes VIH-.Matériel et Méthode : Il s’agit d’une étude cas-témoin monocentrique comparant les taux d’hypertension artérielle gravidique, de prééclampsie, d’éclampsie et de retard de croissance intra utérin vasculaire entre 280 patientes VIH+ et 560 patientes VIH- appariées selon l’âge, la parité et l’origine géographique.Résultats : Le taux de complications vasculo-placentaires n’est pas statistiquement différent entre les patientes VIH+ et VIH- : 7,5% vs 9,8% respectivement (p= 0,27). Les patientes VIH+ ont une augmentation significative des taux de prématurité globale : 18,6% vs 8,0%, p<0,0001 et une diminution significative des poids de naissance pour l’âge gestationnel : 41,6ème percentile vs 46,6ème percentile, p=0,02.Conclusion : Cette étude ne permet pas d’observer de différence d’incidence de complication vasculo-placentaire entre des patientes VIH+ et VIH-. L’augmentation significative de la prématurité et des petits poids de naissance chez les patientes VIH+ est à explorer par des études complémentaires spécifiques
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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