1,720,973 research outputs found
Case Report: Lesson learned on a case of three synchronous NSCLC‘S
No full textBackground: In order to raise discussion on the management of multiple pulmonary nodules,
we describe the unusual case of a 70 years old man affected by three synchronous NSCLC’s
Methods: Past medical history was significant for 40 pack year smoking, hypertension, COPD,
type II diabetes mellitus and gout arthropathy, previous gastric resection for peptic ulcer. An
incidental chest CT scan revealed: 1) a 0,5 cm very small non calcified nodule in the middle lobe;
2) a 2.5 cm nodule in the apical segment of the right upper lobe presenting irregular margins, a
pleural tail and a mixed density; 3) a 2.5 cm nodule, solid and rounded, with irregular borders,
in the posterior segment of the right lower lobe; 4) a 2 cm nodule, solid and irregular, located in
the apical-dorsal segment of the left upper lobe. Trans-bronchial biopsy of the right upper lobe
nodule was positive for bronchiolar-alveolar carcinoma , PET showed ipermetabolic activity in
correspondence of the three bigger nodules. The clinical staging was T1N0M1 (Stage IV).
Results: Considering the impossibility to discriminate among primary or metastatic lesions on
the basis of fine needle biopsies, through mid sternotomy the wedge resection of the nodules was
uneventfully performed. Histology and immunohistochemistry provided diagnosis of synchronous
right lung adenocarcinomas and left lung neuroendocrine carcinoma. The 0,5 cm nodule was
benign. Pathological staging was pT1NXMX. After 24 months the patient is disease free.
Conclusions: When radiological imaging supports the possibility of multiple synchronous
NSCLC’s, an aggressive surgical approach is recommended not to exclude patients from effective
cure
Efficacia della chirurgia antireflusso (fundoplicatio) nella cura della tosse cronica ± associata a sintomi da RGE.
No full textEfficacia della chirurgia antireflusso (fundoplicatio) nella cura della tosse cronica ± associata a sintomi da RGE
Does anatomical segmentectomy allow an adequate lymph node (N) staging for NSCLC?
No full textBackground: Anatomical segmentectomy is again under evaluation for cure of T1 N0 NSCLC.
Whether segmentectomy does permit or not an adequate resection of nodal stations for staging
or cure is still pending.
Methods: We compared 36 (67% male) anatomical segmentectomies (S) and 58 (76% male)
lobectomies (L), performed for T ≤ 2cm N0 M0 at the preoperative work up. Dissection of N
stations number 4/5/6/7 was identical in (S) and (L), stations number 10, 11 and 12 with the
segmental 13 were also dissected carefully during (S).
Results: Number and type of surgical procedures, histology, p Stage, follow up are detailed in
table 1.The mean size of the resected lesions was 1.7 ± 0.7 cm in (S) and 1.8 ± 0.47 cm (p=0.409)
in (L). (S) resection margins were free in 100%. Mean number of dissected lymph nodes was 9.6
± 3.4 in (S) compared to 17 ± 7 in (L) (p=0.001), for N1 it was 5 ± 1.8 in (S) versus 10.2 ± 4.2
in (L) (p=0.001), for N2 was 5.2 ± 2.9 in (S) versus 6.8 ± 4.7 in (L) (p=0.078). In (S) 100% was
N0, in (L) 86,4% was N0, 6.8% N1, 6.8%N2 (4pts ). Actuarial 24 months free from recurrence
survival was 100% for (S) and 96% for (L) , p=0.889).
Conclusions: If compared to standard lobectomy, anatomical segmentectomy for T ≤ 2cm N0,
NSCLC provides a lower number of N1 and the same number of N2 nodes for pathological
examination, 7% of patients may be under-staged (for N1), but the 24 months free from recurrence
survival is equivalent
Effectiveness of antireflux surgery (fundoplication) for the care of chronic cough ± associated with GOR symptoms
No full textObjectives
The outcome of surgical therapy for atypical extra-oesophageal symptoms allegedly secondary to GORD is controversial. Aim of this study was to assess the results of antireflux surgery in patients affected by 1) typical, 2) typical + atypical, (chronic cough), in whom a dedicated preoperative work up was performed.
Methods
Between 1995-2010, 151 patients with GORD-related typical andtor atypical symptoms were submitted to antireflux surgery. 100% preoperatively underwent semi-quantitative evaluation of typical/atypical symptoms, chronic cough and oesophagitis, barium swallow, endoscopy and histology and oesophageal manometry, (24 hour pH-recording or intraluminal impedance/pH monitoring system in the absence of gross oesophagitis). In addition, patients with chronic cough underwent chest HRCT scan, methacholine challenge test and spirometry. Surgery was performed exclusively on patients positive for GORD and negative for pulmonary diseases. Preoperative tests for GORD were repeated at follow-up.
Results
Patients were ordered into two groups: A) 83 patients with typical symptoms only, B) 68 patients with typical symptoms and chronic cough. See table for preoperative clinical and instrumental assessment, type of surgery, morbidity, mortality, follow up and outcomes. In both groups, antireflux surgery demonstrated to significantly improve typical symptoms. The global score for outcome showed no significant differences between group A and B. In group B. antireflux surgery significantly improved chronic cough as well.
Conclusions
The preoperative work up was highly effective in selecting patients for antireflux surgery which achieved very satisfactory results in the treatment of GORD and GORD-related chronic cough.
Disclosure: All authors have declared no conflicts of interest
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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