1,721,029 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
La kinase NDR1, un nouvel acteur de la signalisation des RalGTases, fonctionne comme pivot entre la survie et la mort des cellules cancéreuses
No full textDes mutations du gène Ras jouent un rôle essentiel dans le développement tumoral. Les GTPases Ral , RalA et RalB, sont des effecteurs proximaux de l’oncogène Ras. RalA permet la croissance en absence de substrat et RalB est nécessaire à l'autophagie et à la résistance à l'apoptose des cellules cancéreuses. Cette thèse a pour objectif de clarifier les mécanismes moléculaires de la signalisation Ral impliqués dans l’oncogenèse dépendante des protéines Ras.Des criblages par double hydride ont été effectués par notre équipe et un interactome de Ral a été établi. Ce criblage a montré une interaction entre des protéines de la signalisation Ral et la protéine NDR1, une kinase pro-apoptotique appartenant à la voie " suppresseur de tumeur" Hippo. Le Projet 1 montre la régulation de NDR1 par la voie RalA-Exocyste- MAP4K4 en réponse au stress osmotique, oxydatif ou au traitement par le TNF-α. Dans cette voie, la kinase MAP4K4, un effecteur de RalA, via le complexe exocyste active directement NDR1. En outre, nous avons montré que la voie RalA-MAP4K4-NDR1 était nécessaire à l'apoptose déclenchée par le TNF-α ou par la surexpression de RASSF1A, suppresseur de tumeur appartenant à la voie Hippo. Nous avons donc montré que RalA a un rôle pro-apoptotique inattendue qui agit via la kinase NDR1, en plus de son rôle connu de proto-oncogène en aval de Ras.Le projet 2 montre que la protéine kinase NDR1 est un régulateur de l'autophagie. Des criblages par double hydride ont été effectués par notre équipe avec NDR1 comme appât et ont permis de montrer une interaction entre Beclin 1, une protéine majeure de l’autophagie, et NDR1. Nous avons montré que NDR1 était nécessaire à l'autophagie et à la formation des autophagosomes chez l'humain et la Drosophile. De plus, NDR1 est nécessaire à la formation du complexe Exo84 de l'exocyste, Beclin1 et RalB nécessaire à l'initiation de l'autophagie. Nous montrons également que RalB régule l'état d'activation de NDR 1 après induction de l'autophagie. En effet, en absence de RalB, nous avons observé une hyper - activation de NDR1 menant les cellules vers l'apoptose. Ainsi nous avons montré que NDR1 joue le rôle d'interrupteur favorisant l'autophagie ou favorisant l'apoptose suivant son état d'activation.Le projet 3 étudie l'implication de la voie RalGTPases-NDR1 dans l'oncogenèse dépendante de Ras et dissèque par quels mécanismes NDR1 y contribue.Constitutive Ras signalling is one of the most frequent oncogenic event in human cancers. Thus, it is imperative to identify new therapeutic options targeting downstream effectors of Ras signalling. Ras-like GTPases RalA and RalB are proximal effectors of oncogenic Ras. RalA was reported to support anchorage independent proliferation and RalB regulates autophagy and inhibits apoptosis of cancer cells. Ral proteins execute these functions via several direct effectors as the exocyst, an octameric complex originally identified as regulator of vesicles trafficking. The global goal of this PhD was to better decipher the molecular mechanisms underlying the functions of Ral GTPases in oncogenesis.To extend the Ral interactome, i.e. the protein-protein interaction network centered on Ral, we performed yeast-two hybrid screenings which led to the identification of the NDR1 kinase, belonging to the tumor suppressor Hippo pathway. NDR1 functions in oncogenesis were investigated in the context of three projects.In Project 1, we showed that NDR1-dependent apoptosis is regulated by a RalA/Exocyst/MAP4K4/NDR1 cascade. We reported that under osmotic or oxidative stresses or TNF-α treatment, the Ste20-like MAP4K4 kinase, an effector of RalA via the exocyst complex, directly activates NDR1. Moreover, we found that TNF-α treatment or overexpression of the tumor suppressor RASSF1A, which belongs to the Hippo pathway, leads to apoptosis through this RalA/Exocyst/MAP4K4/NDR1 pathway. This novel and unexpected pro-apoptotic role of RalA suggests that the RalA GTPase can positively signal in tumor suppressor pathways via the kinase NDR1, in addition to its proto-oncogenic role downstream of Ras. In Project 2, we described the NDR1 protein kinase as a conserved regulator of autophagy. Using NDR1 as bait in yeast two hybrid screens, we fished Beclin1, a key regulator of autophagy, and we validated the existence of a direct biochemical NDR1-Beclin1 interaction. We showed that NDR1promotes autophagosome formation in human cells and Drosophila larvae. Furthermore, we observed that NDR1 supports the interaction of the exocyst component Exo84 with Beclin1 and RalB, which is required to initiate autophagosome formation. Very interestingly, under prolonged autophagy, RalB depletion triggers hyperactivation of NDR1 resulting in NDR1-dependent apoptosis. Thus, it appears that the NDR1 kinase could act as a switch between autophagy (=survival) or apoptosis (=death), under the control of RalB. In Project 3, we addressed the role of the newly identified RalGTPases-NDR1axis in Ras - induced oncogenesis and tumorigenesis
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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