727 research outputs found
Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein
No full textOxidative stress affects the availability of key-regulators of vascular homeostasis and controls a number of signaling pathways relevant to myocardial and vascular disease. Reactive oxygen species are generated by different intracellular molecular pathways principally located in mitochondria. The notion that mice carrying a targeted mutation of the p66(Shc) gene display prolonged lifespan, reduced production of intracellular oxidants, and increased resistance to oxidative stress-induced apoptosis prompted a series of studies aimed at defining the biochemical function of p66(Shc) and its possible implication in cardiovascular diseases. Indeed, p66(Shc-/-) mice are protected against vascular, cardiac, and renal impairment attributable to hypercholesterolemia, aging, diabetes, and ischemia/reperfusion. The present review focuses on the biochemical and physiological function of the p66(Shc) adaptor protein as well as on the mechanisms linking p66(Shc)-associated generation of free radicals to the pathophysiology of aging and cardiovascular disease. On the whole, the evidence so far reported and here discussed supports the concept that pharmacological modulation of p66(Shc) expression and activity may be a novel and effective target for the treatment of atherosclerotic vascular disease as well as myocardial adaptation to hypertrophic, inflammatory and neuro-hormonal stimuli in the overloaded heart
Mearuring the orientation and roation rate of 3D printed particles in turbulence
No full textThe orientation distribution and rotations of anisotropic particles in turbulent flows play a key role in many applications ranging from icy clouds to papermaking and drag reduction in pipe flow. However, experimental access to time-resolved orientations of anisotropic particles has not been easy to achieve. The use of 3D printing opens up the possibility to fabricate a wide range of particle shapes with smallest dimension down to 300 μm. So far, we have printed rods, crosses, jacks, triads, tetrads and helical particle shapes. We extract particle orientations from stereoscopic video images using a method of least squares optimization in Euler angle space. We find that in turbulence, the orientation and rotation-rate of many particles can be understood using a simple picture of alignment of both the vorticity and a long axis of the particle with the Lagrangian stretching direction of the flow
Bibliografia di Umberto Romagnoli
No full textA complete bibliography of Umberto Romagnoli writings, introduced by a few lines by editors of the Journal and completed by an essay by Alberto Mattei dealing with some technical aspects of the collection of the
bibliography interwoven with some scholarly life moments of the author
The Challenges Of Politicizing Justice And The Anthropology Of Law [desafios Da Politização Da Justiça E A Antropologia Do Direito]
No full textThe article discusses the challenges faced by an anthropology of law that focuses on western modern societies and on the analysis of the justice system in its relation to issues such as violence against women and violence against the elderly. Building on the debates within the legal-feminist theories, the following subjects are explored: (1) the relationship between universalism and different forms of particularism, (2) the opposition between judicialization of social relations and the politicization of justice, (3) new forms of control that characterize contemporary societies. The author points out the limitations and fallacies of the concept of culture in the understanding of contemporary legal and political dilemmas.532475492Corrêa, M., (1983) Morte Em Família: Representações Jurídicas E Papéis Sexuais, , Rio de Janeiro, GraalCorrêa, M., (1981) Os Crimes Da Paixão, , São Paulo, Editora BrasilienseDebert, G.G., A antropologia e os novos desafios nos estudos de cultura e política (1997) Revista Política E Trabalho, (13)Debert, G.G., Beraldo de Oliveira, M., Os modelos conciliatórios de solução de conflitos e a violência doméstica (2007) Cadernos Pagu, (29)Debert, G.G., Gregori, F., As delegacias especiais de polícia e o projeto gênero e cidadania (2002) Gênero E Cidadania, , in CORRÊA, M. (org.), Campinas, PAGU - Núcleo de Estudos de Gênero, Coleção EncontrosDebert, G.G., Gregori, F., Violência e Gênero: Novas propostas, velhos dilemas (2008) Revista Brasileira De Ciências Sociais, 23 (66)Debert, G.G.E., Oliveira, A.M., A polícia e as formas de feminização da violência contra o idoso (2007) São Paulo Em Perspec-tiva, 21, p. 2Geertz, C., O saber local: Fatos e leis em uma perspectiva comparativa (1999) O Saber Local: Novos Ensaios Em Antropologia Interpretativa, , in C. Geertz, Editora VozesGilligan, C., (1982) Uma Voz Diferente, , Rio de Janeiro, Rosa dos TemposGregori, M.F., Os sentidos políticos do direto à diferença (2000) Novos Estudos CEBRAP, (57)Lins de Barros, M.M., (1987) Autoridade E Afeto. Filhos E Netos Na Família Brasileira, , Rio de Janeiro, Zahar EditoresMoore, S.F., History and the redefinition of custom on kilimanjaro (1989) History and Power in the Study of Law - New Directions in Legal Anthropology, , in J. Starr & J. F. Collier, Ithaca, NY, Cornell University PressNader, L., Up the anthropologist - perspectives gained from studying up (1969) Rein-venting Anthropology, , in Hymes, D. (Ed.), New York, Vintage BooksPierucci, A.F., (2000) Ciladas Da Diferença, p. 34. , São Paulo, EditoraRifiotis, T., As delegacias especiais de proteção à mulher no Brasil e a 'judicialização' dos conflitos con-jugais (2003) Anuário 2003. Direito E Globalização, , Rio de Janeiro, Atas do Seminário do GEDIM, Universidade Cândido MendesRios, R.R., Por uma perspectiva feminista no debate jurídico (2002) Cadernos Themis, 3 (3)Rose, N., Government and control (2000) British Journal of Criminology, 40 (1)Werneck Vianna, L., (1999) A Judicialiazação Da Política E Das Relações Sociais No Brasil, , Rio de Janeiro, Reva
Comment on "the exact seismic response of an ocean and a N-layer configuration" by G.G. Drijkonnigen and J.T. Fokkema. Reply Commentaire sur "reponse sismique exacte d' un ocean et configuration a n-couches" par G.G. Drijkoningen et J.T. Fokkema. Reponse
No full textHuman-induced pluripotent stem cell-derived cardiomyocytes from cardiac progenitor cells: effects of selective ion channel blockade
No full textAIM: Human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes are likely to revolutionize electrophysiological approaches to arrhythmias. Recent evidence suggests the somatic cell origin of hiPSCs may influence their differentiation potential. Owing to their cardiomyogenic potential, cardiac-stromal progenitor cells (CPCs) are an interesting cellular source for generation of hiPSC-derived cardiomyocytes. The effect of ionic current blockade in hiPSC-derived cardiomyocytes generated from CPCs has not been characterized yet.METHODS AND RESULTS: Human-induced pluripotent stem cell-derived cardiomyocytes were generated from adult CPCs and skin fibroblasts from the same individuals. The effect of selective ionic current blockade on spontaneously beating hiPSC-derived cardiomyocytes was assessed using multi-electrode arrays. Cardiac-stromal progenitor cells could be reprogrammed into hiPSCs, then differentiated into hiPSC-derived cardiomyocytes. Human-induced pluripotent stem cell-derived cardiomyocytes of cardiac origin showed higher upregulation of cardiac-specific genes compared with those of fibroblastic origin. Human-induced pluripotent stem cell-derived cardiomyocytes of both somatic cell origins exhibited sensitivity to tetrodotoxin, a blocker of Na+ current (INa), nifedipine, a blocker of L-type Ca2+ current (ICaL), and E4031, a blocker of the rapid component of delayed rectifier K+ current (IKr). Human-induced pluripotent stem cell-derived cardiomyocytes of cardiac origin exhibited sensitivity to JNJ303, a blocker of the slow component of delayed rectifier K+ current (IKs).CONCLUSION: In hiPSC-derived cardiomyocytes of cardiac origin, INa, ICaL, IKr, and IKs were present as tetrodotoxin-, nifedipine-, E4031-, and JNJ303-sensitive currents, respectively. Although cardiac differentiation efficiency was improved in hiPSCs of cardiac vs. non-cardiac origin, no major functional differences were observed between hiPSC-derived cardiomyocytes of different somatic cell origins. Further studies are warranted to characterize electrophysiological properties of hiPSC-derived cardiomyocytes generated from CPCs
Global vulnerability to near-Earth object impact
No full textA clear appreciation of the consequences resulting from an asteroid impact is required in order to understand the near Earth object (NEO) hazard. Three main processes require modelling to analyse the entire impact event. These are the atmospheric entry phase, land impact events and ocean impact events. A range of impact generated effects (IGEs) are produced by different impact scenarios. It is these IGEs that present the threat to human populations world wide, and the infrastructure they utilise. A software system for analysing the NEO threat has been developed, entitled NEOimpactor, to examine the social and economic consequences from land and ocean impacts. Existing mathematical models for the three principal impact processes have been integrated into one complete system, which has the capability to model the various effects of a terrestrial asteroid impact and, critically, predict the consequences for the global population and infrastructure. Analysis of multiple impact simulations provides a robust method for the provision of an integrated, global vulnerability assessment of the NEO hazard. The primary graphical outputs from NEOimpactor are in the form of ‘relative consequence’ maps, and these have been designed to be comprehensible to a non-specialist audience. By the use of a series of multiple-impact simulations, the system has identified the five countries most at risk from the impact hazard, as well as indicating the various factors influencing vulnerability
Spruce Mills
No full textPhotograph - Stacks of lumber at Spruce Mills, Athabasca, Alberta, owned by G.G. Fowle
Fowler Block
No full textPhotograph - Fowler Block, Athabasca, Alberta. The building was built in the early 1950s by G.G. Fowle
The book of airplanes
No full textThe Book of Airplanes Old ModelsStories from the ancients -- The balloon age -- Famous balloon voyages -- Airships -- The zeppelins -- Gliders -- The first flight -- Early airplanes -- War flying -- Air circuses and barnstormers -- Air mail and transport -- The army and the navy -- Crossing seas and continents -- "I am Charles Lindbergh" -- Aviation todayThis volume is based on a book by Mr. G.G. Jackson --forewor
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