1,721,059 research outputs found
HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF EXOCRINE AND ENDOCRINE PANCREATIC LESIONS IN AVIAN INFLUENZA A EXPERIMENTALLY-INFECTED TURKEYS
No full textIn order to investigate the lesions caused by two (H7N1, H7N3) low-pathogenicity avian influenza (LPAI) viruses isolated in turkeys during epidemics in Italy, 28 turkeys experimentally-infected by oro-nasal route and 2 negative controls were submitted to histopathological analysis. Hematobiochemical tests were also performed. Animals euthanized 4 days post-infection (DPI) revealed a moderate multifocal acute necrotizing pancreatitis (3/8). In animals euthanized 7-10 DPI major findings were a moderate-to-severe multifocal-to-diffuse chronic sclerosing pancreatitis and ductular hyperplasia (9/12). In turkeys euthanized 17-39 DPI (8/8) a multifocal moderate-to-severe lymphocytic fibrosing pancreatitis was observed. No lesions were detected in controls. Double-immunolabeled immunohistochemistry for glucagon and avian influenza virus revealed an occasional viral positivity of exocrine pancreas in turkeys euthanized 4-7 DPI whilst the glucagon presence was detected throughout the post-infection course. Immunohistochemistry for insulin revealed positivity in all sections taken from day 4 to 39 post-infection. Insulin-producing cells were more widely distributed than glucagon+ cells. Three out of six turkeys euthanized at 39 DPI were mildly hyperglycemic at 14 DPI and lowered blood glucose levels from 18 to 39 DPI; 4/6 turkeys at 7 DPI showed a marked increase of lipase level that lowered at 14 DPI. One of these 4 animals was also hyperglycemic and showed unusual and marked glucagon/insulin positivity within pancreatic interstitium.
qRT-PCR confirmed the viral presence in pancreas in 2/8 animals euthanized at 4 DPI, in 5/5 turkeys euthanized at 7 DPI and in 1/6 turkeys euthanized at 9 or 10 DPI.
In conclusion, we describe the post infection progression of specific pancreatic morphologic features and of endocrine cell expression, in turkeys experimentally infected with Italian LPAI viruses
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Caractéristiques cliniques et anatomopathologiques des infections à virus influenza aviaire; directives pour la visite des exploitations et diagnostic différentiel
No full text
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
- …
