2,032 research outputs found
Molecular and functional analyses of the human and the murine genes coding for AFG3L1p, a metalloprotease homologous to the human spastic paraplegia protein
No full textElastic-DF: Scaling Performance of DNN Inference in FPGA Clouds through Automatic Partitioning
No full textCustomized compute acceleration in the datacenter is key to the wider roll-out of applications based on deep neural network (DNN) inference. In this article, we investigate how to maximize the performance and scalability of field-programmable gate array (FPGA)-based pipeline dataflow DNN inference accelerators (DFAs) automatically on computing infrastructures consisting of multi-die, network-connected FPGAs. We present Elastic-DF, a novel resource partitioning tool and associated FPGA runtime infrastructure that integrates with the DNN compiler FINN. Elastic-DF allocates FPGA resources to DNN layers and layers to individual FPGA dies to maximize the total performance of the multi-FPGA system. In the resulting Elastic-DF mapping, the accelerator may be instantiated multiple times, and each instance may be segmented across multiple FPGAs transparently, whereby the segments communicate peer-to-peer through 100 Gbps Ethernet FPGA infrastructure, without host involvement. When applied to ResNet-50, Elastic-DF provides a 44% latency decrease on Alveo U280. For MobileNetV1 on Alveo U200 and U280, Elastic-DF enables a 78% throughput increase, eliminating the performance difference between these cards and the larger Alveo U250. Elastic-DF also increases operating frequency in all our experiments, on average by over 20%. Elastic-DF therefore increases performance portability between different sizes of FPGA and increases the critical throughput per cost metric of datacenter inference. Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Computer Engineerin
A familial cryptic subtelomeric deletion 12p with variable phenotypic effect
No full textThe definitive version is available at www.blackwell-synergy.comA 15-year-old-boy and his mother, both carrying a cryptic deletion within 12p13.33, are described. The proband has a mild phenotype with moderate mental retardation and severe behavioural problems. The mother had some learning difficulties at school. Conventional GTL-banded high-resolution chromosome analysis showed normal karyotypes. Subsequent analysis by fluorescence in situ hybridization using a set of probes specific for the subtelomeric regions of all chromosomes, plus a series of probes at 12p13.33 extending from the 12p telomere, showed that both mother and son carry a 1.65 Mb terminal deletion in this region. There are 10 predicted genes within the deleted region. The unanticipated familial nature of the deletion emphasizes the value of family studies in all cases with subtelomeric abnormalities. It also demonstrates the difficulty in making a clinical diagnosis of individuals with this deletion. To the best of the present authors' knowledge, the proband and his mother are the first patients described with a submicroscopic deletion at 12p13.33.E Baker, L Hinton, DF Callen, EA Haan, A Dobbie and GR Sutherlan
Hydrodynamical turbulence by fractal fourier decimation
No full textWe present a systematic numerical investigation of high-resolution 3D isotropic and homogeneous turbulence resolved on a decimated set of Fourier modes. Fractal decimation acts to decrease the effective dimensionality of the flow by allowing triadic interactions only in a set of Fourier modes N(k) proportional to k^DF for large k. While keeping the symmetries of the original 3D Navier-Stokes equations unchanged, a dramatic change in small-scale statistics is detected at decreasing the fractal dimension DF . Already at fractal dimension DF = 2.8, a global self-similar behaviour is observed in the inertial range of scales, the consequence of such transition are the restoration of the scaling symmetry and vorticity distribution that becomes close to Gaussian. We relate the results to the different roles of local vs non-local interactions in the energy transfer range
'Response by the author, Daniel F. Vukovich.'
No full textResponse by the author (Vukovich) to a review of Illiberal China (my 2019 monograph
DF AND HF LASER SPECTRA
No full textW. B. Roh and K. Narahari Rao, J. Mol. Spectrosc. 49, 317 (1974).""Author Institution: Department of Physics, The Ohio State University; Department of Electrical Engineering, The Ohio State UniversityA pulsed laser was used as a source to study DF and HF infrared laser spectra with a grating spectrometer. The rotational structure observed for the 1-0, 2-1, and 3-2 bands of DF, and the 1-0 and 2-1 bands of HF has been measured by following a procedure similar to that used for the CO laser Molecular constants derived by combining these laser measurements with other available data will be presented
OPTOACOUSTIC MEASUREMENT OF DF LASER ABSORPTION BY METHANE
No full textAuthor Institution:An optoacoustic system has been constructed for measurement of absorption of DF laser radiation. Absorption by methane in Argon and Nitrogen has been measured at 15 DF laser lines in the 3.6 – 4.0 region. Construction and calibration of the spectrophone will be discussed
Potential trisomy 21 misdiagnosis by amniocentesis due to a resorbed twin [1]
No full text[No abstract available]CALLEN DF, 1991, PRENATAL DIAG, V11, P437, DOI 10.1002-pd.1970110705; Lloveras E, 2001, PRENATAL DIAG, V21, P896, DOI 10.1002-pd.174; REDDY KS, 1991, PRENATAL DIAG, V11, P679, DOI 10.1002-pd.1970110903; THARAPEL AT, 1989, PRENATAL DIAG, V9, P467, DOI 10.1002-pd.197009070311
Targeting the p53 pathway in Ewing Sarcoma
No full textExtent: 17p.The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53 gene, with approximately 50% of all human malignancies expressing dysfunctional, mutated p53 proteins. Interestingly, genetic lesions in the TP53 gene are only observed in 10% of Ewing Sarcomas, with the majority of these sarcomas expressing a functional wild-type p53. In addition, the p53 downstream signaling pathways and DNA-damage cell cycle checkpoints remain functionally intact in these sarcomas. This paper summarizes recent insights into the functional capabilities and regulation of p53 in Ewing Sarcoma, with a particular focus on the cross-talk between p53 and the EWS-FLI1 gene rearrangement frequently associated with this disease. The development of several activators of p53 is discussed, with recent evidence demonstrating the potential of small molecule p53 activators as a promising systemic therapeutic approach for the treatment of Ewing Sarcomas with wild-type p53.Paul M. Neilsen, Kathleen I. Pishas, David F. Callen and David M. Thoma
A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease
No full textArticle first published online: 15 OCT 2013Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P2 , and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease.Seth A. Jones, Paul M. Neilsen, Limei Siew, David F. Callen, Nathan E. Goldfarb, Ben M. Dunn, and Andrew D. Abel
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