1,721,066 research outputs found
VirusMentha: a new resource for virus-host protein interactions
Full text linkViral infections often cause diseases by perturbing several cellular processes in the infected host. Viral proteins target host proteins and either form new complexes or modulate the formation of functional host complexes. Describing and understanding the perturbation of the host interactome following viral infection is essential for basic virology and for the development of antiviral therapies. In order to provide a general overview of such interactions, a few years ago we developed VirusMINT. We have now extended the scope and coverage of VirusMINT and established VirusMentha, a new virus-virus and virus-host interaction resource build on the detailed curation protocols of the IMEx consortium and on the integration strategies developed for mentha. VirusMentha is regularly and automatically updated every week by capturing, via the PSICQUIC protocol, interactions curated by five different databases that are part of the IMEx consortium. VirusMentha can be freely browsed at http://virusmentha.uniroma2.it/ and its complete data set is available for download
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Archè. L’inizio, il principio, il comando, il dominio
No full textThe analysis of the concept of "beginnning", "principle" and "government" in Pre-Socratic and later Greek Philosoph
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Using the MINT Database to Search Protein Interactions
No full textThe Molecular INTeractions Database (MINT) is a public database designed to store information about protein interactions. Protein interactions are extracted from scientific literature and annotated in the database by expert curators. Currently (October 2019), MINT contains information on more than 26,000 proteins and more than 131,600 interactions in over 30 model organisms. This article provides protocols for searching MINT over the Internet, using the new MINT Web Page. © 2020 by John Wiley & Sons, Inc. Basic Protocol 1: Searching MINT over the internet Alternate Protocol: MINT visualizer Basic Protocol 2: Submitting interaction data
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Communication Transport Protocol Strategies for Rail Applications
No full textCurrent technologies for managing rail traffic such as the Global System for Mobile communications for Railway (GSM-R) will be no longer be available within the upcoming years. The European Shift2Rail Joint Undertaking (S2R-JU) proposed the Adaptable Communication System (ACS) to overcome this problem. In this work, we model the ACS by abstracting it at the Internet Protocol (IP) level, using tunnels for datagrams’ transmission as a communication bearer is available along the rail. Then, to evaluate its performance, an ACS emulator has been implemented. The core part of it is a Tunnel Manager which can establish pseudo-virtual circuits through multi-bearer tunnels, forcing datagrams on a service-basis to follow specific paths between gateways (i.e., from on-board to a train to the network-side rail control center and vice versa). The Tunnel Manager can properly select a given tunnel/bearer for sending messages (and duplicating them on redundant paths) of critical rail applications for train traffic management, relying on tunnels based on either connection-oriented protocol (i.e., the Transport Control Protocol, TCP), connectionless protocol (i.e., the User Datagram Protocol, UDP) or a mix of them. In this paper, we investigate the best solutions in terms of transport protocols for implementing tunnels through the bearers. Results are based on two main use cases: i. the position report/movement authority messages for the European Rail Traffic Management System (ERMTS) and ii. the critical file transmission, considering either TCP or UDP as tunnel transport protocol. For the first rail application, one UDP bearer can be selected only if the end-to-end channel delay is lower than 100 ms and the experienced packet loss is lower than 4% in the whole crossed network. Two UDP bearers, one TCP bearer or two mixed UDP/TCP bearers should be selected in case the channel delay is greater than 300 ms and the experienced packet loss is greater than 15%. Considering the critical file transfer in the rail scenario, TCP should be selected with two bearers to have a throughput greater than 50 Mbit/s even for a packet loss of 1%
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