323,633 research outputs found
Mary Steichen Calderone (1904-1998): Advocate for Sex Education
No full textMary Steichen Calderone, MD, MPH, was the foremost advocate for sex education in the United States during the pivotal decades of the 1960s and 1970s. The authors wrote this article together, based on research for a forthcoming book on Mary Calderone and other advocates for sex education by E. S. More
Computation to Fight SARS-CoV-2 (COVID-19)
No full textIn April 2020, during the last pandemic health emergency, we launched a Special Issue hosted by Computation—section Computational Biology, entitled “Computation to Fight SARS-CoV-2 (COVID-19)” [...
Spinal cord infarction due to fibrocartilaginous embolization: the role of diffusion weighted imaging and short-tau inversion recovery sequences.
No full textFibrocartilaginous embolization is a rare cause of ischemic myelopathy caused by embolization of intersomatic disk nucleus pulposus into spinal vasculature during Valsalva-like maneuvers. Diagnostic criteria are based on patients clinical history, magnetic resonance evidence of T2-hyperintense spinal cord lesion, and exclusion of other causes of ischemic myelopathy. These criteria do not take into account the development of magnetic resonance techniques able to enhance signal abnormalities within the neighboring intersomatic disc or vertebral body and to early characterize central nervous system lesions according to the presence of cytotoxic edema. We present 2 pediatric cases of progressive paraplegia attributed to fibrocartilaginous embolization in which short-tau inversion recovery and diffusion-weighted imaging sequences played a pivotal role showing the ischemic nature of spinal cord lesions. Due to its specificity, diffusion-weighted imaging should be included in the magnetic resonance criteria of fibrocartilaginous embolization and in standard magnetic resonance analysis when dealing with acute transverse myelopathy. © The Author(s) 2010
49. La storiografia ecclesiastica nella tarda antichità. Atti del Convegno Tenuto in Erice (3-8. XII. 1978), sous la direction de S. Calderone
No full textNautin Pierre. 49. La storiografia ecclesiastica nella tarda antichità. Atti del Convegno Tenuto in Erice (3-8. XII. 1978), sous la direction de S. Calderone. In: Revue des Études Grecques, tome 94, fascicule 447-449, Juillet-décembre 1981. p. 582
The ephemeral epiglacial lake of the Ghiacciaio del Calderone (Gran Sasso, Italy)
No full textThe extreme rainfall event around 14-15 September 2012 (estimated cumulative value of approx. 300 mm in the summit area of the Gran Sasso d'Italia mountain range, Central Italy above the elevation of 2500m) generated an ephemeral epiglacial lake at the bottom of the depression of the Ghiacciaio del Calderone. In this short communication a description of the atmospheric triggering phenomena and of the ephemeral lake evolution is presented and some geomorphological remarks briefly discussed
49. La storiografia ecclesiastica nella tarda antichità. Atti del Convegno Tenuto in Erice (3-8. XII. 1978), sous la direction de S. Calderone
No full textNautin Pierre. 49. La storiografia ecclesiastica nella tarda antichità. Atti del Convegno Tenuto in Erice (3-8. XII. 1978), sous la direction de S. Calderone. In: Revue des Études Grecques, tome 94, fascicule 447-449, Juillet-décembre 1981. p. 582
Combining Subtractive Genomics with Computer-Aided Drug Discovery Techniques to Effectively Target S. sputigena in Periodontitis
No full textThis study aimed to provide an inclusive in silico investigation for the identification of novel drug targets that can be exploited to develop drug candidates for treating oral infections caused by S. sputigena. By coupling subtractive genomics with an in silico drug discovery approach, we identified dTDP-4-dehydrorhamnose 3,5-epimerase (UniProt ID: C9LUR0), UTP-glucose-1-phosphate uridyltransferase (UniProt ID: C9LRH1), and imidazole glycerol phosphate synthase (UniProt ID: C9LTU7) as three unique proteins crucial for the S. sputigena life cycle with no substantial similarity to human proteins. These potential drug targets served as the starting point for screening bioactive phytochemicals (1090 compounds) from the Indian Medicinal Plants, Phytochemistry and Therapeutics (IMPPAT) database. Among the screened natural products, cubebin (IMPHY001912) showed a higher affinity for two of the three selected targets, as evidenced by molecular docking and molecular dynamics studies. Given its favorable drug-like profile and possible multitargeting behavior, cubebin could be further exploited as an antibacterial agent for treating S. sputigena-mediated oral infections. It is worth nothing that cubebin could be the active ingredient of appropriate formulations such as mouthwash and/or toothpaste to treat S. sputigena-induced periodontitis, with the advantage of limiting the adverse effects that could affect the use of current drugs
Targeting Opioid Receptors in Addiction and Drug Withdrawal: Where Are We Going?
No full textThis review article offers an outlook on the use of opioids as therapeutics for treating several diseases, including cancer and non-cancer pain, and focuses the analysis on the opportunity to target opioid receptors for treating opioid use disorder (OUD), drug withdrawal, and addiction. Unfortunately, as has been well established, the use of opioids presents a plethora of side effects, such as tolerance and physical and physiological dependence. Accordingly, considering the great pharmacological potential in targeting opioid receptors, the identification of opioid receptor ligands devoid of most of the adverse effects exhibited by current therapeutic agents is highly necessary. To this end, herein, we analyze some interesting molecules that could potentially be useful for treating OUD, with an in-depth analysis regarding in vivo studies and clinical trials
Combinatorial approaches for novel cardiovascular drug discovery: a review of the literature
No full textIntroduction: In this article, authors report an inclusive discussion about the combinatorial approach for the treatment of cardiovascular diseases (CVDs) and for counteracting the cardiovascular risk factors. The mentioned strategy was demonstrated to be useful for improving the efficacy of pharmacological treatments and in CVDs showed superior efficacy with respect to the classical monotherapeutic approach. Areas covered: According to this topic, authors analyzed the combinatorial treatments that are available on the market, highlighting clinical studies that demonstrated the efficacy of combinatorial drug strategies to cure CVDs and related risk factors. Furthermore, the review gives an outlook on the future perspective of this therapeutic option, highlighting novel drug targets and disease models that could help the future cardiovascular drug discovery Expert opinion: The use of specifically designed and increasingly rational and effective drug combination therapies can therefore be considered the evolution of polypharmacy in cardiometabolic and CVDs. This approach can allow to intervene on multiple etiopathogenetic mechanisms of the disease or to act simultaneously on different pathologies/risk factors, using the combinations most suitable from a pharmacodynamic, pharmacokinetic, and toxicological perspective, thus finding the most appropriate therapeutic option
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