169,994 research outputs found
11C-Methionine PET/CT in patients with primary hyperparathyroidism and inconclusive pre-operative imaging work-up: diagnostic accuracy and role of semi-quantitative analysis
No full textObjective: 11C-Methionine PET/CT (C-MET) is a promising method in detecting abnormal parathyroid glands in patients with primary hyperparathyroidism (PHPT). The first aim of the study was to evaluate which is the diagnostic role of C-MET in patients with PHPT and inconclusive pre-operative imaging. Second, we aimed to investigate whether C-MET semi-quantitative parameters may reflect biochemical and histological characteristics of involved glands. Methods: Patients with PHPT, undergoing C-MET after an inconclusive pre-operative imaging and having a parathyroid surgery, were retrospectively included. C-MET visual and semi-quantitative assessment was performed. Parameters, as SUVmax, SUVpeak, SUVmean, functional lesion volume (FLV) and total lesion activity (TLA), were measured for each detected lesion; SUVmean, FLV and TLA were calculated on 40–90% thresholds of SUVmax to define SUVmean40-90, FLV40-90 and TLA40-90, respectively. Results were correlated with patients’ clinical-laboratory (calcium and PTH values) and histological data (size and weight of excised glands). Mann–Whitney test was used and P value < 0.05 was considered significant. Results: Thirty-eight patients (36 female, age: 57.69 ± 15.13 years) were included. Pre-operative median calcium and PTH values were 11.1 mg/dl [interquartile range (IQR) 10.6–11.5] and 154.6 pg/ml (IQR 101.8–227.0), respectively. C-MET showed a parathyroid uptake in 30 out of thirty-eight patients (78.9%). Among 42 nodules excised, C-MET correctly detected the side of the neck (right/left) in 30/42 with sensitivity, specificity and accuracy of 79, 75 and 79%, respectively. C-MET correctly identified the exact position (superior/inferior) in 27/42 with sensitivity, specificity and accuracy of 75, 50 and 71%, respectively. SUVpeak, FLV50-70 and TLA40-70 were significantly (P < 0.05) higher in patients with higher PTH results. The histological size resulted significantly (P < 0.05) higher in abnormal glands with higher SUVmax, SUVpeak, FLV40-80 and TLA40-90, the weight was higher in glands with higher SUVpeak, SUVmean40-50, FLV40-80 and TLA40-90. Conclusions: C-MET showed a good performance in detecting hyperfunctioning parathyroid glands in PHPT patients with inconclusive pre-operative imaging. Semi-quantitative PET-derived parameters closely correlated with PTH as well as with size and weight of the excised gland, thus reflecting some biochemical and histological characteristics of involved glands
Dural MALT Lymphoma Detected by 11C-Methionine PET/CT
No full textA 53-year-old man had a diagnosis of mucosa-associated lymphoid tissue lymphomas of the dura in the left tentorium. The patient underwent whole-body F-FDG PET/CT and C-methionine PET/CT in order to complete the staging of dural mucosa-associated lymphoid tissue lymphoma. C-methionine uptake was detected in multiple meningeal sites, including left tentorium, with no significant FDG uptake in the same regions
Class I and II resin-composite restorations using two different adhesives: prospective RCT
No full textSEM analysis of the interference between bleaching and enamel etching
No full textAim. SEM (Scanning Electron Microscope) evaluation of the existance of micromorphological differences between unbleached enamel (SNS) and bleached enamel (SS) and between etched enamel (SM) and etched after bleaching enamel (SSM). In the latter cases the etching agent has been applied right after bleaching to explore potential interferences between the two processes.
Methods. 12 upper incisors have been selected. The professional bleaching agent Opalescence Quick 45% PF (Ultradent Products Inc.) has been applied for 30 minutes on part of the vestibular surface of each specimen. After rinsing the specimens, a 37% ortophosphoric acid (Best Etch – Vista Dental Products) has been applied for 45 seconds on the whole surface, including the enamel part that had been bleached. The effect on the enamel surface has been evaluated with the scanning electron microscope (SEM).
Results. and Conclutions. We obtained 48 pictures that showed micromorphological differences between SNS and SS. In most of the cases (9 specimens on 12 examined) there are no micromorphological differences between SM and SSM; but since on the other 25% of the cases, the difference between SM and SSM is rimarkable, we can hypothesize that is the natural composition of the idrossiapathite of each element that determines the final answer to the consecutive use of peroxide and ortophosphoric acid
From Model Scale to Full Size. On Turbulence Stimulation in Resistance Model Tests of High Speed Craft
No full textA Case of Primary Localized Small Bowel Amyloidosis Studied by 18F-Choline and Contrast-Enhanced 18F-FDG PET/CT
No full textAmyloidosis is a rare hereditary or acquired protein deposition disorder with different etiologies, characterized by pathological protein deposition essentially in nearly any organs or tissues. There are 2 major forms: primary and secondary amyloidosis. Moreover, it is possible to have systemic or localized disease. The localized form of amyloidosis affecting the small intestine is rare, and it is characterized by the formation of precursor proteins at the site of the lesion. We report a case of localized small bowel amyloidosis studied by F-choline and F-FDG-iodinated PET/CT performed for staging an aggressive prostatic cancer
- …
