1,071 research outputs found
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
Ep. #181 - Nigel Clark
No full textThis recording and transcript form part of a collection of podcasts conducted by the Cultures of Energy at Rice University. Cultures of Energy brings writers, artists and scholars together to talk, think and feel their way into the Anthropocene. We cover serious issues like climate change, species extinction and energy transition. But we also try to confront seemingly huge and insurmountable problems with insight, creativity and laughter.Cymene and Dominic discuss a strange effort to police sugar packet play on this week’s podcast. Then (15:52) we are delighted to welcome Nigel Clark to the conversation. Nigel is Chair of Social Sustainability and Human Geography at Lancaster University (https://www.lancaster.ac.uk/lec/about-us/people/nigel-clark ). He is the author of Inhuman Nature: Sociable Life on a Dynamic Planet (2011) and co-editor of Atlas: Geography, Architecture and Change in an Interdependent World (2012), Material Geographies (2008) and Extending Hospitality(2009). We start things off by talking about a new book he is working on called The Anthropocene and Societythat he is working on with Bron Szerszynski and what it means to rethink humanity through planetary strata, flows, and multiplicity. We turn from there to Australian feminism, phosphates, Aotearoa New Zealand as a space of settler grassland experiments, wealth, and geocide. Then we touch on fire and its excess, our brittle life on an earth’s surface caught between solar and geothermal vitalities, metamorphosis, the early connection between gunpowder and combustion engines and European geotrauma. A special birthday week shout-out to our very own eternal Cymene Howe :
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Peripheral Neuropathy and Sexual Dimorphism in Prion Disease Mouse Models
No full textIn this study, I characterize peripheral neuropathic phenotypes in F35 mice (knock-out model of prion disease) and 93N mice (novel knock-in model of prion disease) using various behavioral assays, electrophysiology, and histology. F35 mice and 93N mice show significant impairment of small unmyelinated C-fibers without systemic loss of nerve density in either the foot skins or the cornea. In analyzing large fiber function, F35 mice and 93N mice show significant slowing of motor nerve conduction velocity. However, only 93N male mice show significant impairment in large sensory nerve fiber function, suggesting a model- and sex-specific peripheral neuropathic phenotype in the knock-in model. Structural analysis of axon caliber distribution in sciatic nerves show significantly smaller mean axonal diameter in diseased mice, but no difference in total amount of large myelinated fibers. Overall, axonal size-frequency in sciatic nerves of diseased mice appear heavily skewed toward smaller nerve fibers. Analysis of myelin sheath g-ratio show thinner axon diameters in only F35 mice compared to wild type mice, but post-hoc analysis of only male mice shows that F35 and 93N males both have smaller axonal diameters compared to wild types. The presence of peripheral nerve pathology in both mice despite a lack of prion aggregates in the central nervous systems of both mouse models suggests that prion aggregates may not be necessary to activate prion neurotoxic pathways
Maine Interview piece with Nigel Calder of Alna, author of the Boatowners\u27s M
No full textMaine Interview piece with Nigel Calder of Alna, author of the Boatowners\u27s Mechanical and Electrical Manual, which has sold over 90,000 copies, and a number of other books, including The Cruising Guide to the Northwest Caribbean and Cuba: A Cruising Guide
Modern vacuum practice
No full textModern Vacuum Practice is an easy-to-understand introduction to high vacuum technology suitable for anyone using high vacuum as a tool. The author provides a fundamentally non-mathematical treatment of the subject, assuming little or no prior vacuum knowledge throughout. With its emphasis always on providing practical information, the book gives the reader the knowledge to set up, use, maintain and troubleshoot a vacuum system
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Effects of M1R Antagonism in Treating Chemotherapy Induced Peripheral Neuropathy
No full textChemotherapy induced peripheral neuropathy (CIPN) is a debilitating condition that affects up to 70% of patients undergoing chemotherapy treatment. CIPN causes a mix of small and large fiber damage as well as motor dysfunction that occurs less frequently but varies patient to patient. CIPN is categorized as a “dying-back” axonal degeneration in which neurodegeneration proceeds in a distal-to-proximal manner. There is currently no FDA-approved prophylactic or treatment for CIPN. In vitro research has shown that rat sensory neurons exposed to chemotherapeutics exhibited reduced neurite outgrowth, but neurons that were concurrently exposed to the muscarinic acetylcholine receptor 1 (M1R) antagonist pirenzepine (PZ) were protected from chemotoxicity. To investigate the practical application of this effect, indices of CIPN were measured in Swiss Webster mice treated with chemotherapeutics paclitaxel, oxaliplatin, and bortezomib. Subcutaneous PZ treatment prevented and reversed indices of neuropathy and neuropathic pain in each drug class. The translational therapeutic potential of PZ was explored by testing varied routes of administration and dose frequencies. Topical PZ had no effect on transient tactile allodynia but was able to reverse MNCV slowing in mice with paclitaxel induced CIPN. Dose frequency was examined as a possible variable in topical PZ efficacy. Topical PZ reversed tactile allodynia at each dose frequency and reversed mild MNCV slowing. My data suggests that M1R may be a viable target in preventing and reversing CIPN
Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms?
No full textNeuropathy is a common complication of long-term diabetes that impairs quality of life by producing pain, sensory loss and limb amputation. The presence of neuropathy in both insulin-deficient (type 1) and insulin resistant (type 2) diabetes along with the slowing of progression of neuropathy by improved glycemic control in type 1 diabetes has caused the majority of preclinical and clinical investigations to focus on hyperglycemia as the initiating pathogenic lesion. Studies in animal models of diabetes have identified multiple plausible mechanisms of glucotoxicity to the nervous system including post-translational modification of proteins by glucose and increased glucose metabolism by aldose reductase, glycolysis and other catabolic pathways. However, it is becoming increasingly apparent that factors not necessarily downstream of hyperglycemia can also contribute to the incidence, progression and severity of neuropathy and neuropathic pain. For example, peripheral nerve contains insulin receptors that transduce the neurotrophic and neurosupportive properties of insulin, independent of systemic glucose regulation, while the detection of neuropathy and neuropathic pain in patients with metabolic syndrome and failure of improved glycemic control to protect against neuropathy in cohorts of type 2 diabetic patients has placed a focus on the pathogenic role of dyslipidemia. This review provides an overview of current understanding of potential initiating lesions for diabetic neuropathy and the multiple downstream mechanisms identified in cell and animal models of diabetes that may contribute to the pathogenesis of diabetic neuropathy and neuropathic pain
A standing ovation for Nigel: An informal study
No full textThis article analyses a series of emails thanking Nigel for his stewardship of JASSS and the characteristics of their authors. It identifies a correlation between two measures of author activity in social simulation research, but no pattern between these activity measures and the email timing. Instead, the sequence suggests a classic standing ovation effect.</p
Semiometrics: Applying Ontologies across Large-Scale Digital Libraries
No full textAs large-scale digital libraries become more available and complete, not to mention more numerous, it is clear there is a need for services that can draw together and perform inference calculations on the metadata produced. However, the traditional Relational Database Management System (RDBMS) model, while efficiently constructed and optimised for many business structures, does not necessarily cope well with issues of concurrent data updates and retrieval at the scale of hundreds of thousands of papers. At the same time the growth of RDF and the increasing interest in Semantic Web technologies perhaps begins to present a viable alternative at a scalable, practical level. This paper considers a specific application of large-scale metadata analysis and conducts scalability tests using real-world data. It concludes that RDF technologies are both a scalable and performance-realistic alternative to traditional RDBMS approaches. It also shows that for relationship-based queries on large-scale metadata stores, RDF technologies can significantly out-perform traditional RDBMS approaches by allowing both retrieval and updating of data in a timely manner
The Writer Walking the Dog: Creative Writing Practice and Everyday Life
No full textCreative writing happens in and alongside the writer’s everyday life, but little attention has been paid to the relationship between the two and the contribution made by everyday activities in enabling and shaping creative practice. The work of the anthropologist Tim Ingold supports the argument that creative writing research must consider the bodily lived experience of the writer in order fully to understand and develop creative practice. Dog-walking is one activity which shapes my own creative practice, both by its influence on my social and cultural identity and by providing a time and space for specific acts instrumental to the writing process to occur. The complex socio-cultural context of rural dog-walking may be examined both through critical reflection and creative work. The use of dog-walking for reflection and unconscious creative thought is considered in relation to Romantic models of writing and walking through landscape. While dog-walking is a specific activity with its own peculiarities, the study provides a case study for creative writers to use in developing their own practice in relation to other everyday activities from running and swimming to shopping, gardening and washing up
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