1,355,569 research outputs found
Regulation of Balb/c3T3 fibroblast proliferation by B-myb is accompanied by selective activation of cdc2 and cyclin D1 expression.
No full textThe B-myb gene is expressed in many cell types at the G1/S transition of the cell cycle. Inhibition of B-myb expression in BALB/c 3T3 fibroblasts by introduction of a B-myb antisense construct greatly diminished cell proliferation, whereas constitutive expression of a human B-myb cDNA in these cells reduced their growth factor requirements and induced a transformed phenotype. Constitutive expression of B-myb cDNA was accompanied by activation of cyclin D1 and cdc2 expression but not of cyclin A and cyclin B. Transfection of BALB/B-myb cells (a cell line expressing high levels of exogenous human B-myb) with a cyclin D1 antisense construct drastically reduced cloning efficiency of these cells. These results suggest that the B-myb-encoded product regulates fibroblast proliferation by activating cdc2 and cyclin D1 gene expression and that abnormal expression of cyclin D1 might be a step in the process of transformation
ESTABLISHED OR OUTSIDERS? Rileggere Elias nella collettività tunisina di Modena
No full textThe works of Elias, characterised by his unique relational and processual gaze, have recently inspired much research in the migration field. In particular, the established-outsiders figuration has opened a fruitful way to overcome the tendency of naturalising cultural and economic differences, hiding the power relations among different groups.
The objective of this paper is to apply the figurational framework to the study of the Tunisian community living in Modena (Northern Italy). The originality of the study resides in the choice of a particular figuration in which three interdependent groups are present: the Italian autochthones, the elder Tunisian community and the new group of Tunisians arrived after 2011.
Following the process of establishment of the elder part of the Tunisian community we observe how a structural change in the figuration (as the arrival of a new group of Tunisian people) had deep social and symbolic consequences, hindering the integration of the old Tunisians in the Modenese context.
The study marks an advancement in the application of the established-outsiders figuration in the migration studies and constitutes a valid example for analysing the integration of increasingly older migrant communities in Italy
La riunificazione in mostra. Musei ed esposizioni a Berlino dopo il 1989
No full textL’articolo analizza come i musei di Berlino presentano i temi della rivoluzione pacifica (il processo che condusse al crollo del Muro di Berlino e alla fine della DDR) e della successiva riunificazione tedesca. L’articolo concentra la sua attenzione su quattro differenti musei storici (Deutsches Historisches Museum, DDR-Museum, Mauer-Museum, Stasi-Museum) e analizza inoltre due mostre temporanee («Wir sind das Volk!» e «1990: der Weg zur Einheit»), tenutesi a Berlino nel 2009/2010, in occasione delle celebrazioni del ventennale della rivoluzione pacifica e della riunificazione. Analizzando le diverse strategie espositive e le interpretazioni storiche offerte, l’autore mette in evidenza come i musei e le esposizioni prese in esame vadano a comporre una narrazione articolata ed eterogenea degli eventi dell’89/90. A guidare l’analisi è la consapevolezza del ruolo che i musei giocano nella costruzione della memoria pubblica, aspetto che si cerca di approfondire proprio attraverso questa ricerca.The article aim is to analyze how Berlin museums display the peaceful revolution (the movement that caused the fall of the Berlin Wall and the end of GDR) and the following German reunification. The article focuses on four different historical-museums (Deutsches Historisches Museum, DDR-Museum, Mauer-Museum, Stasi-Museum). Furthermore it examines two temporary exhibitions («Wir sind das Volk!» and «1990: der Weg zur Einheit»), that took place in Berlin in 2009/2010. Looking at the different exhibition strategy and at the slightly different historical interpretations the museums offer, the author underlines how museums and exhibitions develop heterogeneous depiction of the 1989/90 events. The museums role in building the public memory is the key-concept of the article, and this inquiry wants to represent a way to analyze it
Leukemia stem cells: Old concepts and new perspectives
No full textMyeloid leukemias are heterogeneous malignancies in morphology, immunophenotype, genetic and epigenetic alterations, and response to therapy. This heterogeneity is thought to depend on the accumulation of secondary mutations enhancing proliferation/survival and/or blocking differentiation in a small subset of leukemia-initiating cells capable of self-renewal. This model of clonal evolution is based on xenotransplantation studies demonstrating that leukemia can be initiated and maintained in immunodeficient mice by a small subset of purified leukemic cells immunophenotypically similar to normal hematopoietic stem cells and is known as the leukemia stem cell model. Since its original formulation, many studies have validated the main conclusion of this model. However, recent data from xenotransplantation studies in more severely immunodeficient mice suggest that imunophenotype and behavior of leukemic stem cells is more heterogeneous and "plastic" than originally thought. We will discuss here the evolution of the leukemia stem cell model and its impact for the therapy of patients with myeloid malignancies
The economic backstage of the landings of emigrants on the island of Lampedusa. An exemplary case of migration industry
No full textThis article focuses on Lampedusa as an exemplary case study of eco-nomic transformation brought about by migration, as well as the creation of a ‘mi-gration industry’.On the basis of interviews with key informants and a reconstruction of the secondaryliterature, it shows how migration has given international visibility to the island,starting from the first arrivals of emigrants in the 1990s, through the increase inlandings during the so-called ‘Arab Spring’, and up to the present. This has fed var-ious processes of conversion from an economy based on fishing towards an economybuilt around relatively recent tourism. Furthermore, it highlights how the national,European and international policies of migration governance have contributed tocreating an industry based on consumption by the military, police, volunteers, healthand humanitarian personnel present on the island and the impact this has had on thelocal service sector
Conceptualizing and operationalizing firm innovativeness through decision perspective: a cross-disciplinary study
No full textNo abstract availabl
New Product Development and dynamic capabilities: a framework and an empirical test
No full textNo abstract availabl
L'eredità della DDR. Controversie a Berlino dopo il 1989
No full textL'articolo offre un'ampia disamina dei processi che hanno investito l'eredità materiale della DDR a Berlino dopo il 1989, analizzando le sorti dei monumenti, della toponomastica e degli edifici governativi della ex capitale della Germania orientale.The article focuses on the GDR heritage in Berlin, analyzing the different processes that involved monuments, streets names and government buildings. After the GDR collapse its symbolic and material heritage was at the center of the public attention. Berlin had a key position: the East part was the GDR capital city till 1989, while, between 1990-1991, the city returned to be the FRG capital and the seat of the national government (instead of Bonn). The GDR memory issue was particularly controversial because it was closely related to the building of a reunified Germany identity.
The question about what should be removed and what should be preserved revealed political cleavages and provoked conflicts. The decision-making process about the GDR heritage involved different actors: city government, federal government, civic associations and independent committees. The processes related to the GDR statues (above all on one side the removal of Lenin's statue, on the other the preserving of Thälmann's bust and of the Marx and Engels' statues) and the renaming of some East Berlin streets went on until 1994. Instead the controversy about the Palace of Republic lasted for many years and divided deeply West and East Berlin citizens. This Palace indeed was both the GDR Parliament seat and a cultural center, well known and visited by the former GDR citizens. The decision to tear down the Palace and to rebuild the baroque Castle (demolished by GDR in 1950) was at the core of the public discussion for years.
The decision-making process regarding the GDR architectonic and monumental heritage reveals its symbolic role regarding the GDR collective memory and the reunified German identity
Introduction. Sayad and Migrants’ Descendants: A Renewed Gaze
No full textDespitebeing widely known and cited, Abdelmalek Sayad remains an author subject to divergent representations and interpretations and frequently reduced to a superficial use of some of his most famous concepts. Contrary to this simplifying reading, Sayad’s work crosses different fields of study and is characterised by a particular reflexive depth. Through migration, the author is able to analyse the dynamics of social and symbolic inclusion and exclusion, the construction and modification of social hierarchies at both local and international levels, and social change and conflict at large. In this sense, Sayad also offers important and little explored keys to understanding the experiencesand trajectories of the children of migration. This introductory contribution aims to draw attention to the way Sayad has studied migrants’descendants, highlighting how his approach is helpful for the renewal of this field of study. The contribution concludes with a presentation of the papers that are part of this Special Issue
Young people with Tunisian origins living in Italy: a case of transnational lived citizenship?
No full textIn recent years, the merging of the lived citizenship approach with the transnational perspective has shed a brighter light on the spatiality of everyday citizenship practices. Starting from this premise, the present study investigates whether and how a group of young people, aged between 22 and 28, with Tunisian parentage residing in the province of Modena (Northern Italy) live their citizenship transnationally. It involves questioning what their citizenship practices are, whether their transnational ties translate into lived citizenship, and what are the sites in which these people live their citizenship. The study draws on 14 in-depth interviews collected between 2020 and 2021, offering fresh insights into the role of transnational bonds in shaping the geographies and the contents of citizenship practices among young people with migrant parents. The findings confirm the heuristic validity of merging the transnational perspective with the lived citizenship approach, especially when inquiring into the practices of citizenship among migrants’ descendants
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