125,170 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Internalization Pathway of Amyloidogenic Serum Free Light Chains
No full text• “Internalization pathway of amiloydogenic Serum Free Light Chains”
Ricotta D., Di Noto G., Dossi A., Paolini L., Radeghieri A., Amoroso B. and Caimi L.
Poster communication at 6th International Symposium on Clinical Applications of Serum Free Light Chain Analysis (plus Hevylite). Bath, UK on 23rd and 24th September 2010
Primary (AL) Amyloidosis is a disease of protein misfolding. During plasma cell dyscrasia, such as micromolecular myeloma, plasma cells produce a great amount of monoclonal immunoglobulin free light chains (kappa or lambda FLCs) that may accumulate in different peripheral districts and determine tissue damages. It has been shown that FLCs induce oxidative stress and FLCs internalization in cardiac fibroblasts enhances sulfatation of secreted glycosaminoglycans (GAGs) suggesting that the intracellular trafficking pathway of FLCs could be correlated with the amiloydogenic potential of paraproteins.
AIMS
The mechanism of internalization and trafficking of FLCs is not well understood, so we aimed to characterize this pathway.
METHODS
In order to identify a correlation between the FLC phenotype and their pathogenicity, we have investigated the internalization rate of different lambda and kappa FLCs (belonging to hospitalized patients) in different cellular lines. Indeed, the mechanisms of internalization in different cellular subtypes might be an important key in the study of different pathological conditions strictly correlated to FLCs (systemic and not only kidney related) metabolism.
RESULTS SUMMARY/CONCLUSION
Our results highlight that the monoclonal FLCs of every patient behaves in a different way in different cellular lines and we could also show that not only epithelial cells are able to process paraproteins. Considering these data we could hypothesize that the interaction of FLCs with peripheral districts depends on high specific receptors expressed on certain cellular lines and/or that each patient has an individual clinical pattern due to the paraprotein molecular structure
A dip in the pool in Milan: Cozzi and Caimi swimming pools
No full textThe construction of a capillary system of swimming pools in Milan was part of Mussolini’s Fascist sports programme, in which politics, architecture and urban planning were intertwined.
This policy left us with sports facilities that are still in use today and that, at the time of their construction, were internationally renowned for their technical and technological research, innovative spatial solutions and attention to the relationship with figurative art.
Starting from this premise, the article examines the construction history of the Cozzi and Caimi pools, designed by the engineer Secchi
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Effects of exercise on inflammation markers in type 2 diabetic subjects.
No full textEndothelial dysfunction and plasma markers of inflammation are significantly increased in type 2 diabetics. Several proinflammatory cytokines, acute-phase proteins, and cell adhesion molecules, such as C-reactive protein (CRP), interleukines (IL), and tumor necrosis factor alpha (TNF-α), seem to play a role in the low-grade systemic inflammation observed in these subjects. Lifestyle changes are necessary to prevent atherosclerosis and cardiovascular events. Physical exercise is known to reduce markers of inflammation by decreasing adipocytokine production and cytokine release from skeletal muscles, endothelial cells, and immune system and also improving antioxidant status. In type 2 diabetics, aerobic and resistance training have different effects on cytokine levels, and the differences in the modalities of exercise (type, duration, and intensity) and especially in the examined population could produce different results. Recent research showed that combined exercise has greater anti-inflammatory effects than aerobic or resistance exercise alone causing a deepest decrease in CRP, IL-6, IL-1β, TNF-α, leptin, and resistin and a higher increase in anti-inflammatory cytokines such as IL-4, IL-10, and adiponectin
Giulio Caimi as an art theoretician and painter (1897-1982)
No full textIn Part One, after the Prologue, the Introduction and the Biography Details of Julio Caimi, there is an extensive overview of the historical context within which the artistic and theoretical production of Caimi emerged, on the one hand, and a presentation of the stance he took over against the so-called ‘Generation of the 30s’, on the other. Further on, the formation of Caimi is presented as an artist with his own distinctive character and as an original interpreter of texts. Finally, Part One of the thesis is concluded with a comprehensive consideration of Caimi’s visual oeuvre: his attempts at landscape painting, his portraits, themes in his works taken from the Bible, as well as some samples of ‘still life’.Part Two includes the extensive literary production of Caimi: the books he wrote and published mainly during the 1930s, but also after the war, as well as his numerous articles in newspapers and periodicals. This Part closes with the conclusions of the thesis, according to which Caimi constitutes a basically unknown chapter in modern Greek art; a chapter that consciously deviated from the ‘canon’ regarding Hellenicity by suggesting an alternative view with global and universal perspectives. The thesis also includes a Part Three, in which in the manner of an Appendix one can find the following: (a) a catalogue of the known and accessible paintings by Caimi, (b) previously unknown and unpublished materials regarding his life and activities, (c) bibliography, (d) the sources of the photos used, (e) an index of names, and (f) the reproductions of the works that are studied in the thesis.Στο Πρώτο Μέρος της διατριβής, μετά τον Πρόλογο, την Εισαγωγή και τα Βιογραφικά Στοιχεία του Τζούλιο Καΐμη, γίνεται εκτενής αναφορά αφενός μεν στο ιστορικό πλαίσιο εντός του οποίου αναπτύχθηκε η καλλιτεχνική και τεχνοκριτική παραγωγή του Καΐμη, αφετέρου δε στη στάση που ο ίδιος κράτησε απέναντι στη λεγόμενη «Γενιά του ’30». Στη συνέχεια παρουσιάζεται η διαμόρφωση του Καΐμη ως καλλιτέχνη με το δικό του ιδιαίτερο στίγμα και ως πρωτότυπου ερμηνευτή κειμένων. Τέλος, το Πρώτο Μέρος της διατριβής ολοκληρώνεται με μία περιεκτική εξέταση του εικαστικού έργου του Καΐμη: τις προσπάθειές του στην τοπογραφία, τις προσωπογραφίες του, τα θέματα έργων του από τη Βίβλο, καθώς και κάποια δείγματα «νεκρής φύσης».Στο Δεύτερο Μέρος περιλαμβάνεται η εκτεταμένη συγγραφική δραστηριότητα του Καΐμη: τα βιβλία που συνέγραψε και εξέδωσε κυρίως κατά τη δεκαετία του 1930, αλλά και μεταπολεμικά, καθώς και τα πολυάριθμα άρθρα του σε εφημερίδες και περιοδικά. Το παρόν Μέρος κλείνει με τα συμπεράσματα της διατριβής, σύμφωνα με τα οποία ο Καΐμης αποτελεί ένα άγνωστο εν πολλοίς κεφάλαιο της νεοελληνικής τέχνης, το οποίο διαφοροποιήθηκε συνειδητά από τον «κανόνα» περί ελληνικότητας, προτείνοντας μία εναλλακτική πρόταση με παγκόσμιες και καθολικές προοπτικές. Η διατριβή περιλαμβάνει και Τρίτο Μέρος, στο οποίο, δίκην παραρτήματος, έχουν συγκεντρωθεί: (α) κατάλογος με τα γνωστά και προσβάσιμα έργα του Καΐμη, (β) άγνωστο μέχρι τώρα και αδημοσίευτο υλικό σχετικά με τη ζωή και τη δράση του, (γ) βιβλιογραφία, (δ) οι πηγές της εικονογράφησης, (ε) ευρετήριο ονομάτων και (στ) οι εικόνες των έργων που εξετάζονται στη διατριβή
Mario Caimi, Kant's B Deduction, Newcastle upon Tyne, Cambridge Scholars Publishing, 2014.
No full textThe volume by Mario Caimi published in the series "Kantian Questions" edited by Pablo Muchnik presents the English translation of his previous Leçons sur Kant. La déduction transcendentale dans la deuxième édition de la "Critique de la raison pure" (Paris, 2007), originated in a lecture he held at the Sorbonne in 2004
interactions of pig brain cytosolic sialidase with gangliosides. the formation of catalytically inactive enzyme-ganglioside complexes requires homogeneous ganglioside micelles and is reversible phenomenon
No full textCytosolic sialidase A, obtained from pig brain and purified, interacts with ganglioside GT1b giving two catalytically inactive enzyme-ganglioside complexes. Treatment of these complexes with Triton X-100 under given conditions (1% detergent; 1 h at 37°C; 0.1 M acetic acid-sodium acetate buffer, pH4.8) leads to the liberation of part of the enzyme (about 47%) in a free and fully active form. Reversible inactivation of cytosolic sialidase requires the presence of homogeneous micelles of GTlb or of mixed micelles (for instance Triton X-100 and GT1b) with a high GT1b content. Triton X-100/ganglioside mixed micelles with a molar ratio above 50, as well as small unilamellar vesicles of egg yolk lecithin and GTlb (7-15 mol%), did not inactivate the enzyme at all; on the contrary these forms of ganglioside dispersion behaved as excellent substrates for the enzyme. It is to be concluded that under in vitro conditions the ability of ganglioside to interact with cytosolic sialidase, giving rise to catalytically inactive complexes or to Michaelis-Menten enzyme-substrate complexes, depends on the supramolecular organization of the ganglioside molecules. Arrangements of tightly packed molecules with strong side-side interactions facilitate the formation of complexes with the enzyme; arrangement with separated and loosely interacting molecules facilitates binding at the catalytically active site of the enzyme
Behaviour of nitric oxide metabolites in unprofessional athletes before and after a cardiopulmonary test
No full textPhysical training causes an increase in nitric oxide (NO) production [2, 3, 8, 9] and this datum explains
the link between exercise and endothelium and seems to demonstrate how regular training upregulates
eNOS expression, although it is not sure if this upregulation is due to shear stress or metabolic factors
[3]. However, it must be underlined that besides to be directly influenced by exogenous NO, erythrocytes
express a functional NOS [5, 6, 11, 13] that raises the circulation NO pool.
The literature data describe that an 8-week exercise training induced an increase in plasma levels of NO
metabolites (NOx), that persisted four weeks after interruption of training [8]. A similar trend was also
found after a 12-week physical training [9]. Other authors noted instead that at baseline the NOx level
was higher in sedentary young subjects compared to the older ones while this difference was not present
between younger and older athletes; this difference was eliminated in sedentary subjects by physical
training [2].
Now we evaluated the NOx level before and after a cardio-pulmonary test in unprofessional athletes
who practised different kinds of sports, in comparison with sedentary controls (SC)
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